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Biochemistry & Molecular Biology
Najeeb Ur Rehman, Sulaiman Al-Shidhani, Nasiara Karim, Ajmal Khan, Imran Khan, Sobia Ahsan Halim, Sajid Khan Sadozai, Satya Kumar Avula, Rene Csuk, Ahmed Al-Harrasi
Summary: Through the study of derivatives of two active substances in the resin of Boswellia papyrifera, it is found that these derivatives have good anti-depressive properties and have great application potential. Further research indicates that these compounds produce GABAergic effects by binding to the GABA binding site of the GABA(A) receptor.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Rohit Pal, Bhupinder Kumar, P. M. Guruubasavaraja Swamy, Pooja A. Chawla
Summary: A series of substituted-N-(5,6-diphenyl-1,2,4-triazin-3-yl) benzamides were designed, synthesized, and evaluated for their antidepressant-like activity. Compound R:5 and R:9 exhibited potent MAO-A inhibition activity and significant antidepressant effects in FST and TST. ADME and docking studies further confirmed their pharmacological characteristics and binding abilities.
BIOORGANIC CHEMISTRY
(2023)
Article
Neurosciences
Zhicheng Jin, Jianer Ling, Jing Yu, Mengzi He, Pingping Ni, Fang Zhang, Yizhen Wang
Summary: The study revealed that hypothyroidism induces depressive behaviors, with the influence of the serotonin system playing a significant role, and the decreased expression of the 5-HT2A receptor being a crucial factor in the depressive behaviors associated with hypothyroidism.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yusuf S. Althobaiti
Summary: Addiction to drugs and chemicals is a global public health concern. The prescription medication mirtazapine (MIRT) has been reported to be abused and can induce withdrawal symptoms. In this study using mice, it was found that MIRT can induce drug-seeking behavior, impair recognition, and cause withdrawal symptoms. These findings suggest that MIRT may have the potential to induce drug dependence.
SAUDI PHARMACEUTICAL JOURNAL
(2022)
Article
Neurosciences
Arnab Nandi, Garima Virmani, Aatmika Barve, Swananda Marathe
Summary: FST and TST are common behavioral tests for screening antidepressant drugs and assessing non-motor symptoms in movement disorder animal models. Manual analysis of these tests is time-consuming with large variability, but the open-source program DBscorer provides automated and unbiased analysis, allowing for a nuanced understanding of behavioral despair expression.
Article
Integrative & Complementary Medicine
Sun Dan-chen, Wang Ran-ran, Xu Hao, Zhu Xue-hui, Sun Yan, Qiao Shi-qing, Qiao Wei
Summary: This study investigated the pharmacodynamic material basis, mechanism of actions, and targeted diseases of Salicornia europaea L. (SE) using the network pharmacology method. Pharmacological experiments verified the antidepressant-like effect of SE extract and suggested that it may regulate the Nrf2-ARE pathway and increase levels of dopamine and corticosterone in the hippocampus and cortex.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Neurosciences
Faizan Ul Haq, Mohammad Shoaib, Syed Wadood Ali Shah, Haya Hussain, Muhammad Zahoor, Riaz Ullah, Ahmed Bari, Amal Alotaibi, Muhammad Faisal Hayat
Summary: This study aimed to synthesize benzodiazepine derivatives and evaluate their antidepressant potentials. The results showed that compounds 2 and 5 exhibited significant antidepressant effects and increased GABA levels in the brain's hippocampus of experimental animals, indicating the possible involvement of the GABAergic mechanism.
Article
Behavioral Sciences
Aida A. C. Brandao, Deborah L. S. Deus, Luiz A. M. S. Duarte-Filho, Pedro M. N. Menezes, Ana B. R. Massaranduba, Fabricio S. Silva, Luciano A. A. Ribeiro
Summary: Through nebulization delivery, ketamine can significantly reduce depressive-like behaviors in mice, indicating that nebulization can be an effective and inexpensive route of drug administration for behavioral research.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Behavioral Sciences
Joanna Kowalczyk, Modestos Nakos-Bimpos, Alexia Polissidis, Christina Dalla, Nikolaos Kokras, Krystyna Skalicka-Wozniak, Barbara Budzynska
Summary: This study found that xanthotoxin can reduce depressive behaviors in male mice, while female mice have lower immobility levels compared to males, which may be related to higher levels of serotonin in the female prefrontal cortex. Additionally, xanthotoxin can lead to a dose-dependent increase in serotonin and noradrenaline levels in the female prefrontal cortex.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Marcela Pereira, Isadora P. Siba, Alexandra Acco, Diego Correia, Fernanda R. Lapa, Adair R. S. Santos, Ana P. Ruani, Moacir G. Pizzolatti, Roberto Andreatini
Summary: The study found that myricitrin can reverse depressive behavior induced by chronic mild stress and reduce adrenal hypertrophy and levels of the inflammatory cytokine IL-6 in the hippocampus. This suggests that myricitrin has antidepressant and anti-inflammatory effects.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Plant Sciences
Imane Es-safi, Hamza Mechchate, Amal Amaghnouje, Amine Elbouzidi, Mohamed Bouhrim, Noureddine Bencheikh, Christophe Hano, Dalila Bousta
Summary: The study aimed to investigate the effects of different doses of Pimpinella anisum total extract on anxiety, depression, and memory in mice. The results showed that PATE has anxiolytic and antidepressant effects, but no impact on memory.
Article
Neurosciences
Ya-Nan Yin, Jian Hu, Yi-Li Wei, Ze-Lin Li, Zhou-Cai Luo, Rui-Qi Wang, Ke-Xin Yang, Shu-Ji Li, Xiao-Wen Li, Jian-Ming Yang, Tian-Ming Gao
Summary: All organisms experience stress, which can lead to mood disorders like depression. Research has shown that lactate in astrocytes plays a key role in modulating the passive coping response to behavioral challenges.
NEUROSCIENCE BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Hyun-Jung Park, Woojin Jeong, Hyo Jeong Yu, Minsook Ye, Yunki Hong, Minji Kim, Ji Youn Kim, Insop Shim
Summary: Grounding is a therapeutic technique that involves activities reconnecting us to the earth, and its effects on sleep and pain have been studied. This study investigated the stress-related behavioral effects of an earthing mat in rats and found that it reduced stress-induced behavioral changes and expression of certain proteins in the brain.
Article
Behavioral Sciences
Liuchang Zhou, Dan Liu, Zedan Xie, Di Deng, Guoqi Shi, Jinlan Zhao, Shasha Bai, Lei Yang, Rong Zhang, Yafei Shi
Summary: The dorsal raphe nucleus (DRN) is a crucial source of serotonin in the central nervous system and is closely associated with depression-like behaviors. This study reveals that gamma oscillation is linked to despair-like behaviors, while burst fraction is important for survival-like behaviors. Through optogenetics, it was found that serotonin transporter-positive neurons are mostly survival units, and approximately 50% of survival units belong to parvalbumin-positive neurons. These findings provide new insights into the study of anti-depression targets and highlight the role of GABAergic interneurons in the coding and regulation of local neural networks.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Chemistry, Medicinal
Yizhen Wang, Aijuan Tian, Fang Zhang, Jing Yu, Jianer Ling
Summary: Hypothyroidism is associated with mental disorders, particularly depression, but the mechanism is still unknown. The inflammatory immune process in the brain may play a key role in the development of depressive symptoms in hypothyroidism. This study used micro positron emission tomography imaging to evaluate microglial activation in the brain of hypothyroid rats and found that activation in the hippocampus is significantly increased. The findings suggest that microglial activation in the hippocampus is important in the development of depressive behaviors in hypothyroidism.
Article
Neurosciences
Xian-Feng Huang, Wen-Tao Jiang, Li Liu, Fang-Chen Song, Xia Zhu, Gui-Lan Shi, Shu-Ming Ding, Heng-Ming Ke, Wei Wang, James M. O'Donnell, Han-Ting Zhang, Hai-Bin Luo, Yi-Qian Wan, Guo-Qiang Song, Ying Xu
CNS NEUROSCIENCE & THERAPEUTICS
(2018)
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Chemistry, Medicinal
Xian-Feng Huang, Yi-Jing Cao, Jing Zhen, Da-Wei Zhang, Ren Kong, Wen-Tao Jiang, Ying Xu, Guo-Qiang Song, Heng-Ming Ke, Li Liu
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Clinical Neurology
Ling Chen, Suying Cui, Haiyang Yu, Gaowen Li, Na Liu, Qiang Wu, Han-Ting Zhang, James M. O'Donnell, Gang Wang, Ying Xu
JOURNAL OF PSYCHOPHARMACOLOGY
(2019)
Article
Neurosciences
Ying-Cong Yu, Jing Li, Meixi Zhang, Jian-Chun Pan, Ying Yu, Jian-Bo Zhang, Liang Zheng, Jian-Min Si, Ying Xu
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Neurosciences
Yang Yang, Qi Chen, Quanfeng Zhao, Ying Luo, Ying Xu, Weimin Du, Hong Wang, Huan Li, Lu Yang, Congli Hu, Jiahua Zhang, Yuke Li, Hui Xia, Zhihao Chen, Jie Ma, Xiaoyan Tian, Junqing Yang
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Chemistry, Medicinal
Mark E. Gurney, Richard A. Nugent, Xuesheng Mo, Janice A. Sindac, Timothy J. Hagen, David Fox, James M. O'Donnell, Chong Zhang, Ying Xu, Han-Ting Zhang, Vincent E. Groppi, Marc Bailie, Ronald E. White, Donna L. Romero, A. Samuel Vellekoop, Joel R. Walker, Matthew D. Surman, Lei Zhu, Robert F. Campbell
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
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Neurosciences
Xia Zhu, Wenhua Li, Yongkun Li, Wenhua Xu, Yirong Yuan, Victor Zheng, Hanting Zhang, James M. O'Donnell, Ying Xu, Xiaoxing Yin
Article
Pharmacology & Pharmacy
Su-Ying Cui, Ming-Xin Yang, Yong-He Zhang, Victor Zheng, Han-Ting Zhang, Mark E. Gurney, Ying Xu, James M. O'Donnell
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2019)
Article
Immunology
Long He, Guang Han, Shaogen Wu, Shibin Du, Yang Zhang, Weili Liu, Baochun Jiang, Luyao Zhang, Shangzhou Xia, Shushan Jia, Stephen Hannaford, Ying Xu, Yuan-Xiang Tao
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Clinical Neurology
Yirong Yuan, Linlin Zhen, Zhi Li, Wenhua Xu, Huilin Leng, Wen Xu, Victor Zheng, Victor Luria, Jianchun Pan, Yuanxiang Tao, Hanting Zhang, Shengsheng Cao, Ying Xu
JOURNAL OF PSYCHOPHARMACOLOGY
(2020)
Article
Neurosciences
Jianxin Li, Ling Chen, Gaowen Li, Xiaojuan Chen, Sisi Hu, Liang Zheng, Victor Luria, Jinpeng Lv, Yindi Sun, Ying Xu, Yingcong Yu
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Neurosciences
Meng-Jia Zhu, Jing Shi, Yong Chen, Guobing Huang, Xiong-Wei Zhu, Sam Zhang, Xian-Feng Huang, Guo-Qiang Song, Han-Ting Zhang, Heng-Ming Ke, James M. O'Donnell, Li-Qun Wang, Ying Xu
PSYCHOPHARMACOLOGY
(2020)
Article
Cell Biology
Mengqi Li, Songxue Su, Weihua Cai, Jing Cao, Xuerong Miao, Weidong Zang, Shichao Gao, Ying Xu, Jianjun Yang, Yuan-Xiang Tao, Yanqiu Ai
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Cell Biology
Yulu Wang, Shichao Gao, Victor Zheng, Ling Chen, Min Ma, Shichen Shen, Jun Qu, Hanting Zhang, Mark E. Gurney, James M. O'Donnell, Ying Xu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Neurosciences
Fang-fang Zhang, Hao Wang, Yan-meng Zhou, Hai-yang Yu, Melanie Zhang, Xian Du, Dong Wang, Feng Zhang, Ying Xu, Ji-guo Zhang, Han-Ting Zhang
Summary: PDE4 inhibitors exert antinociceptive effects by regulating the cAMP-Cx43 signaling pathway in the spinal cord, increasing the expression of Cx43, and reducing mechanical hypersensitivity-induced pain.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)