Article
Neurosciences
Wojciech K. Panek, David M. Murdoch, Margaret E. Gruen, Freya M. Mowat, Robert D. Marek, Natasha J. Olby
Summary: Similar neurological disorders associated with aging, such as Alzheimer's disease and canine cognitive dysfunction syndrome, have been observed in both humans and dogs. The concentrations of A beta 42 and A beta 40 in plasma increase with age in both species, but decrease in individuals with the diseases.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Nutrition & Dietetics
Xinting Jiang, Liang Cui, Lin Huang, Yihan Guo, Gaozhong Huang, Qihao Guo
Summary: This study examines the relationship between beverage consumption and cognitive impairment. It shows that the consumption of green tea, coffee, and pure milk can protect cognitive function, while low water intake increases the risk of cognitive impairment. These associations are influenced by baseline cognitive status, gender, and A beta deposition.
Article
Medicine, Research & Experimental
Chung-Yuh Tzeng, Wei-Shan Lee, Keng-Fan Liu, Hsi-Kai Tsou, Chun-Jung Chen, Wen-Huang Peng, Jen-Chieh Tsai
Summary: This study investigated the effect and mechanism of action of allantoin on AD-related memory impairment. The results showed that allantoin could improve cognitive impairment in A beta(1-42)-induced rats by activating the PI3K/Akt/GSK-3 beta signaling pathway to reduce abnormal hyperphosphorylation of Tau. These findings suggest that allantoin may be a potential therapeutic agent for neurodegenerative diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Bin Wang, Xu Lin, Jiahui Zhou, Chunhui Xie, Chuan Li, Rui Dong, Gaofeng Zhang, Xiaopeng Sun, Mingshan Wang, Yanlin Bi
Summary: The study assessed the therapeutic effects of IGF-1 on POCD in aged rats, showing that IGF-1 reduced Aβ-protein production and inhibited neuronal apoptosis in the hippocampus, subsequently alleviating the symptoms of POCD.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Weiying Chen, Zhenzhou He, Mengting Jiang
Summary: The study demonstrated the neuroprotective effect of thiopental sodium against ISO-induced cognitive dysfunction in rats by modulating oxidative stress and inflammatory responses.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Yanjun Guo, Qinqiu Wang, Shenghui Chen, Chengfu Xu
Summary: This article summarizes the regulatory effects of APP and its cleavage peptides on metabolism in the central nervous system and peripheral tissues, indicating that peptides generated by non-amyloidogenic processing can have positive effects on metabolism, while those produced by amyloidogenic processing may have negative impacts. Abnormal expression of APP is associated with metabolic diseases (such as diabetes, obesity, etc.) and cancer.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Behavioral Sciences
Yuangui Zhang, Qingqing Sun, Aixia Fan, Guimin Dong
Summary: Isoflurane can cause acute neuronal damage by damaging mitochondria and inhibiting the viability and promoting the apoptosis of hippocampal neurons through inactivation of the NR2B/CaMKII/CREB pathway. The harmful effects of isoflurane can be partially ameliorated by adding CaMKII activator CdCl2.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Maria Elisabetta Clementi, Beatrice Sampaolese, Gabriele Di Sante, Francesco Ria, Rosa Di Liddo, Vincenzo Romano Spica, Fabrizio Michetti
Summary: The study demonstrated that the expression of S100B in astrocytoma cells plays a crucial role in the activation of reactive astrocytic processes, including cytotoxicity, ROS and NOS activation. Silencing S100B in astrocytoma cells effectively protected the cells from amyloid beta-peptide-induced damage, reducing cell death, oxygen radical generation and nitric oxide synthase activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Roland Nicsanu, Carlo Cervellati, Luisa Benussi, Rosanna Squitti, Roberta Zanardini, Valentina Rosta, Alessandro Trentini, Clarissa Ferrari, Claudia Saraceno, Antonio Longobardi, Sonia Bellini, Giuliano Binetti, Orazio Zanetti, Giovanni Zuliani, Roberta Ghidoni
Summary: This study investigated the role of serum BACE1 activity as a biomarker for Alzheimer's disease (AD). Results showed that BACE1 levels were increased in AD and MCI-AD patients and could accurately discriminate patients with high sensitivity and specificity. High BACE1 levels were associated with worse cognitive performance and earlier disease onset.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Anna Sulatskaya, Anastasiia O. Kosolapova, Alexander G. Bobylev, Mikhail Belousov, Kirill S. Antonets, Maksim Sulatsky, Irina M. Kuznetsova, Konstantin K. Turoverov, Olesya Stepanenko, Anton A. Nizhnikov
Summary: Both amyloids and beta-barrel proteins have beta-sheet-rich structures, with the latter being able to form functional amyloids in vivo. These beta-barrel amyloid proteins can interact with each other and form toxic oligomers, potentially contributing to the development of amyloidoses. Rapidly growing discoveries suggest that the number and diversity of functions of amyloid-forming beta-barrel proteins are significantly greater than currently understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Paula Alexandra Postu, Marius Mihasan, Dragos Lucian Gorgan, Fatima Zahra Sadiki, Mostafa El Idrissi, Lucian Hritcu
Summary: The present study evaluated the potential medicinal effects of Pinus halepensis Mill. essential oil (PNO) in an Alzheimer's disease (AD) environment. The results showed that PNO has anxiolytic and antidepressant properties and can restore redox imbalance in rats with AD-like neuropsychiatric impairments. Additionally, PNO demonstrated beneficial effects against neuroinflammation and neuroapoptosis in the AD rat model induced by amyloid beta1-42 (A beta 1-42).
Article
Biochemistry & Molecular Biology
Samar O. El-Ganainy, Omar A. Soliman, Aya A. Ghazy, Maram Allam, Aya I. Elbahnasi, Amira M. Mansour, Mennatallah A. Gowayed
Summary: Oxytocin has neuroprotective potential in Alzheimer's disease, restoring cognition and suppressing beta-amyloid, Tau accumulation, and neuronal death. Combined treatment with galantamine and oxytocin shows better biochemical and histopathological profiles.
NEUROCHEMICAL RESEARCH
(2022)
Article
Psychology, Multidisciplinary
Kimberly D. Mueller, Lianlian Du, Davide Bruno, Tobey Betthauser, Bradley Christian, Sterling Johnson, Bruce Hermann, Rebecca Langhough Koscik
Summary: This study demonstrates that the Logical Memory (LM) task is effective in discriminating ability levels and amyloid status, and that individual items vary in difficulty and discrimination based on amyloid status. These findings can inform the development of sensitive tasks or composite scores for early detection of cognitive decline.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jofre Seira Curto, Maria Rosario Fernandez, Josep Cladera, Nuria Benseny-Cases, Natalia Sanchez de Groot
Summary: Homeostasis is crucial for cell function and disturbances in homeostasis can lead to health disorders. This study investigated how pH levels affect the aggregation of amyloid-beta-peptide (A beta) and the development of Alzheimer's disease. The results showed that the brain pH and different aggregated conformations play a role in the aggregation process. Furthermore, neutral pH and physiological salt concentrations were found to favor a slow aggregation with low cytotoxic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Siddhartha Banerjee, Divya Baghel, Md Hasan Ul Iqbal, Ayanjeet Ghosh
Summary: Spontaneous aggregation of amyloid beta (Afi) proteins is a key pathological feature of Alzheimer's disease, but the structure of early-stage aggregates is not well understood. This study used atomic force microscopy-infrared nanospectroscopy to investigate the aggregation process of Afi 16-22 and found a structural transition from oligomers with parallel β-sheets to antiparallel fibrils.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Clinical Neurology
Jiejie Li, Anxin Wang, Xingquan Zhao, Liping Liu, Xia Meng, Jinxi Lin, Jing Jing, Xinying Zou, Yilong Wang, Yongjun Wang
Letter
Immunology
Zhiyi Zuo, Zhi Wang, Shiyu Meng, Shuling Peng
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Hematology
Jiejie Li, Yilong Wang, Hao Li, Zhiyi Zuo, Jinxi Lin, Anxin Wang, Xingquan Zhao, Liping Liu, Yongjun Wang
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Clinical Neurology
Ming Yang, Anxin Wang, Jiejie Li, Xingquan Zhao, Liping Liu, Xia Meng, Jing Jing, Nan Zhang, S. Claiborne Johnston, Yilong Wang, Yongjun Wang
Article
Neurosciences
Foquan Luo, Jia Min, Jumei Wu, Zhiyi Zuo
MOLECULAR NEUROBIOLOGY
(2020)
Article
Clinical Neurology
Jiejie Li, Kehua Quan, Yilong Wang, Xingquan Zhao, Zixiao Li, Yuesong Pan, Hao Li, Liping Liu, Yongjun Wang
FRONTIERS IN NEUROLOGY
(2020)
Article
Biochemistry & Molecular Biology
Fei Lin, Weiran Shan, Yuxin Zheng, Linghui Pan, Zhiyi Zuo
Summary: Post-operative cognitive dysfunction (POCD) is associated with poor clinical outcomes. The study found that TLR2 contributes to surgery-induced neuroinflammation and cognitive impairment, with HMGB1 up-regulating TLR2 expression to facilitate this effect. Therefore, TLR2 and HMGB1 may be potential targets for reducing POCD.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Jia Min, Zhongmeng Lai, Hui Wang, Zhiyi Zuo
Summary: Surgery reduces neuroligin 1 expression in the brain, while environmental enrichment (EE) for 2 weeks can reduce postoperative cognitive dysfunction (POCD). The protective effect of EE on POCD may be mediated through preserving neuroligin 1 expression by attenuating surgery-induced epigenetic dysregulation.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Zhongmeng Lai, Weiran Shan, Jun Li, Jia Min, Xianzhang Zeng, Zhiyi Zuo
Summary: Surgery-induced cognitive dysfunction in adult mice can be improved by low intensity exercise, which reduces neuroinflammation and promotes gut microbiota diversity. The exercise effects on learning and memory were also present in non-exercise mice receiving feces from exercise mice. Valeric acid, a gut microbiota product, worsens neuroinflammation, learning, and memory in mice with surgery, but exercise reduced its levels in the blood. This study suggests that gut microbiota alteration plays a role in POCD development and exercise may have potential therapeutic benefits for brain health in the presence of insults like surgery.
MOLECULAR PSYCHIATRY
(2021)
Article
Chemistry, Multidisciplinary
Juan Xin, Weiran Shan, Jun Li, Hai Yu, Zhiyi Zuo
Summary: A study found that surgery activates the LHb-VTA neural circuit, which is associated with POCD and neuropathological changes in the brain.
Article
Genetics & Heredity
Hui Wang, Gang Ma, Jia Min, Jun Li, Weiran Shan, Zhiyi Zuo
Summary: Exposure to surgery with anesthesia early in life may lead to abnormal behavior, learning, and memory in humans. This study investigates the role of glial cell-derived neurotrophic factor (GDNF) and the inhibition of the ERK-CREB pathway in these effects. The results show that surgery and anesthesia decrease GDNF concentration, impair learning and memory, and increase proinflammatory cytokines. Intracerebroventricular injection of GDNF attenuates inflammation and inhibits ERK. Surgery also increases brain-derived natriuretic peptide (BNP) which impairs learning and memory through ERK inhibition and GDNF reduction.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Multidisciplinary Sciences
Ziyad O. Knio, Lena Zhang, David A. Watts, Zhiyi Zuo
Summary: This study investigated the effect of surgical start time on blood transfusion after gastric bypass surgery. The findings show that patients who underwent surgery between 15:00 and 18:43 had an increased risk of blood transfusion. This suggests that surgical start time may be associated with the occurrence of blood transfusion.
Article
Neurosciences
Qun Jiang, Mingyan Guo, Zhiyi Zuo
Summary: The aim of this study was to investigate whether living with familiar observers attenuates learning and memory dysfunction in mice with surgery. The results showed that living with familiar observers reduced anxiety and dysfunction of learning and memory in young adult male mice with surgery. It also attenuated learning and memory dysfunction and neuroinflammation in old male mice.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Letter
Neurosciences
Jun Li, Weiran Shan, Zhiyi Zuo
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Ting Zhou, Jun Li, Aobing Cheng, Zhiyi Zuo
Summary: Hypoxic-ischemic (HI) brain injury is a major cause of mortality and morbidity in neonates and children. A study investigated the protective effects of desflurane, a volatile anesthetic, against HI-induced brain damage and the role of TRPA1 in this protection. The results showed that desflurane attenuated brain tissue loss and improved neurological functions. It also inhibited the expression of TRPA1, which played a role in HI-induced brain injury.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)