Review
Psychiatry
Katherine H. O. Deane, Oluseyi F. Jimoh, Priti Biswas, Alex O'Brien, Sarah Hanson, Asmaa S. Abdelhamid, Chris Fox, Lee Hooper
Summary: The study found that increasing long-chain Omega-3 has little or no effect on preventing depression and anxiety symptoms, while increasing alpha-linolenic acid may slightly increase the risk of depression symptoms, but with low-quality evidence.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
R. Erhardt, B. R. Cardoso, B. J. Meyer, S. Brownell, S. O'Connell, S. Mirzaee, R. L. Duckham, H. Macpherson
Summary: This study examined the relationship between circulating omega-3 LCPUFA levels and dietary intake of DHA and EPA with cognition and physical function in community-dwelling older adults at risk of dementia. Results showed that higher dietary intake of DHA and EPA were associated with better cognitive function, while higher dietary EPA intake was linked to better attention and mobility. No associations were found between erythrocyte omega-3 LCPUFA levels and cognitive or functional performance measures in this cohort.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Review
Biochemistry & Molecular Biology
Kamila P. Liput, Adam Lepczynski, Magdalena Ogluszka, Agata Nawrocka, Ewa Polawska, Agata Grzesiak, Brygida Slaska, Chandra S. Pareek, Urszula Czarnik, Mariusz Pierzchala
Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Ivana Djuricic, Philip C. Calder
Summary: Oxidative stress and inflammation are important contributors to chronic non-communicable diseases. Different types of fatty acids have varying effects on chronic diseases, with moderate intake of Ω-6 fatty acids lowering the risk of cardiovascular diseases and Ω-3 fatty acids helping to reduce inflammation levels.
Article
Obstetrics & Gynecology
J. Stanhiser, A. M. Z. Jukic, D. R. McConnaughey, A. Z. Steiner
Summary: The study found that self-reported use of omega-3 fatty acid supplements was associated with an increased probability of conceiving.
HUMAN REPRODUCTION
(2022)
Article
Nutrition & Dietetics
Annick P. M. van Soest, Ondine van de Rest, Renger F. Witkamp, Tommy Cederholm, Lisette C. P. G. M. de Groot
Summary: The study found that the efficacy of B-vitamin supplementation in slowing cognitive decline is related to DHA status, with individuals with higher plasma DHA levels benefiting more. There was no significant link between B-vitamin treatment and combined omega-3 fatty acid or EPA levels.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Roberta Cardim Lessa, Fabio de Abreu Alves, Erika Fortunati, Jun Lu
Summary: Oral mucositis (OM) is a painful condition caused by cancer treatments, impacting patients' quality of life and recovery. Current management strategies are insufficient, necessitating a search for new approaches. Utilizing ω-3 fatty acids to manage OM may be an effective strategy based on preliminary evidence.
Article
Clinical Neurology
C. S. Patch, E. L. Hill-Yardin, L. Ryan, E. Daly, Alan J. Pearce
Summary: While emerging evidence suggests the impact of head injury on neurodegenerative diseases such as Alzheimer's disease and chronic traumatic encephalopathy, there is currently no evidence to support or refute the effectiveness of n-3FA intervention in older adults with a history of head trauma. Therefore, further human research is urgently needed to validate the therapeutic potential of n-3FA in this area.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Spencer Loong, Samuel Barnes, Nicole M. Gatto, Shilpy Chowdhury, Grace J. Lee
Summary: The elderly population is growing rapidly, and the nutrients associated with omega-3 FAs in healthy foods and diets are significantly related to cognition and brain health. This study found that increased levels of omega-3 FAs are associated with improved memory, processing speed, and brain structure in healthy older adults.
Review
Nutrition & Dietetics
Daniel Rodriguez, Carl J. Lavie, Andrew Elagizi, Richard V. Milani
Summary: This paper discusses the importance of using omega-3 fatty acids in cardiovascular diseases and summarizes related research and recommendations.
Article
Nutrition & Dietetics
Annick P. M. van Soest, Ondine van de Rest, Renger F. F. Witkamp, Nathalie van der Velde, Lisette C. P. G. M. de Groot
Summary: This study investigated the associations between adherence to a plant-based diet and cognitive ageing. The results showed that overall adherence to a plant-based diet was not associated with cognitive function or cognitive change. However, fish consumption was found to influence the association between adherence to a plant-based diet and cognitive functioning.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Kaitlyn B. Hartnett, Bradley J. Ferguson, Patrick M. Hecht, Luke E. Schuster, Joel I. Shenker, David R. Mehr, Kevin L. Fritsche, Martha A. Belury, Douglas W. Scharre, Adam J. Horwitz, Briana M. Kille, Briann E. Sutton, Paul E. Tatum, C. Michael Greenlief, David Q. Beversdorf
Summary: This pilot study aimed to explore the relationship between stress exposure and dietary omega-3 fatty acid intake in relation to the risk of Alzheimer's disease (AD). The results showed that among individuals with high stress exposure, healthy controls had significantly higher omega-3 fatty acid intake compared to AD patients. No difference was observed among those with low stress exposure. These preliminary findings suggest that omega-3 fatty acids may mitigate AD risk in the setting of greater stress exposure.
Article
Geriatrics & Gerontology
Roxana Coras, Brian Pedersen, Rekha Narasimhan, Anahy Brandy, Lourdes Mateo, Agueda Prior-Espanol, Arthur Kavanaugh, Aaron M. Armando, Mohit Jain, Oswald Quehenberger, Melania Martinez-Morillo, Monica Guma
Summary: The study revealed that arthritis symptoms in older adults were related to disturbances in serum oxylipins, suggesting that certain oxylipins may be key effectors in arthritis in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Nutrition & Dietetics
Luisa Martins Miller, Flavia Benetti Piccinin, Ubele van der Velden, Sabrina Carvalho Gomes
Summary: This systematic review examined the additional effect of taking omega-3 supplements on non-surgical periodontal therapy. The results showed a high level of uncertainty and no definitive conclusion about the benefits of omega-3 supplementation. However, two six-month studies showed promising effects, which encourage further research with better-defined protocols and greater methodological rigor.
Article
Geriatrics & Gerontology
R. De Giuseppe, I. Di Napoli, C. E. Tomasinelli, Alessandra Vincenti, G. Biino, E. Sommella, L. Ferron, P. Campiglia, F. Ferrara, P. M. Casali, H. Cena
Summary: This study aimed to investigate the effects of Camelina oil-enriched crackers on serum omega-3 concentration, inflammatory markers, and serum lipid profile. The results showed that consuming Camelina oil-enriched crackers significantly increased the serum concentration of alpha-linolenic acid, but had no significant effects on inflammatory markers and lipid profile.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Neurosciences
Mansi P. Saraf, Pooja Balaram, Fabien Pifferir, Razvan Gamanut, Henry Kennedy, Jon H. Kaas
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Neurosciences
Mansi P. Saraf, Pooja Balaram, Fabien Pifferi, Henry Kennedy, Jon H. Kaas
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Correction
Multidisciplinary Sciences
Katarzyna Bozek, Ekaterina E. Khrameeva, Jane Reznick, Damir Omerbasic, Nigel C. Bennett, Gary R. Lewin, Jorge Azpurua, Vera Gorbunova, Andrei Seluanov, Pierrick Regnard, Fanelie Wanert, Julia Marchal, Fabien Pifferi, Fabienne Aujard, Zhen Liu, Peng Shi, Svante Paeaebo, Florian Schroeder, Lothar Willmitzer, Patrick Giavalisco, Philipp Khaitovich
SCIENTIFIC REPORTS
(2019)
Article
Anatomy & Morphology
Julie Royo, Fabienne Aujard, Fabien Pifferi
FRONTIERS IN NEUROANATOMY
(2019)
Review
Physiology
Clara Hozer, Fabien Pifferi, Fabienne Aujard, Martine Perret
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Neurosciences
Charlotte Gary, Suzanne Lam, Anne-Sophie Herard, James E. Koch, Fanny Petit, Pauline Gipchtein, Stephen J. Sawiak, Raphaelle Caillierez, Sabiha Eddarkaoui, Morvane Colin, Fabienne Aujard, Jean-Philippe Deslys, Emmanuel Brouillet, Luc Buee, Emmanuel E. Comoy, Fabien Pifferi, Jean-Luc Picq, Marc Dhenain
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2019)
Review
Pharmacology & Pharmacy
Fabien Pifferi, Jacques Epelbaum, Fabienne Aujard
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Hanane Hadj-Moussa, Jing Zhang, Fabien Pifferi, Martine Perret, Kenneth B. Storey
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2020)
Review
Clinical Neurology
Fabien Pifferi, Fabienne Aujard
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Review
Nutrition & Dietetics
Fabien Pifferi, Stephen C. Cunnane, Philippe Guesnet
Article
Biology
Clara Hozer, Fabien Pifferi
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2020)
Review
Zoology
Yohann Chaudron, Fabien Pifferi, Fabienne Aujard
Summary: Gray mouse lemur, a species with relatively slow aging, presents similarities to human pathological aging in terms of cognitive decline, brain atrophy, amyloidosis, and glucoregulatory imbalance. Studying aging in mouse lemurs offers promising insights for understanding, preventing, and treating pathological aging in humans, with potential focus on nutrition as a nonpharmacological antiaging strategy.
AMERICAN JOURNAL OF PRIMATOLOGY
(2021)
Article
Biology
Clara Hozer, Fabien Pifferi
Summary: This study examined the relationship between endogenous period and biomarkers of aging, finding that a deviation of endogenous period from 24 h led to increased oxidative stress, decreased IGF-1 concentrations, and impaired learning performances. These results support the circadian resonance theory, demonstrating a connection between endogenous period and lifespan, aging, and biological performance.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Public, Environmental & Occupational Health
Geoffroy Berthelot, Stacey Johnson, Philippe Noirez, Juliana Antero, Adrien Marck, Francois-Denis Desgorces, Fabien Pifferi, Patrick A. Carter, Michael Spedding, Archana Singh Manoux, Jean-Francois Toussaint
ARCHIVES OF PUBLIC HEALTH
(2019)
Article
Biology
Fabien Pifferi, Jeremy Terrien, Julia Marchal, Alexandre Dal-Pan, Fathia Djelti, Isabelle Hardy, Sabine Chahory, Nathalie Cordonnier, Loic Desquilbet, Murielle Hurion, Alexandre Zahariev, Isabelle Chery, Philippe Zizzari, Martine Perret, Jacques Epelbaum, Stephane Blanc, Jean-Luc Picq, Marc Dhenain, Fabienne Aujard
COMMUNICATIONS BIOLOGY
(2018)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)