期刊
BEHAVIOURAL BRAIN RESEARCH
卷 226, 期 2, 页码 548-554出版社
ELSEVIER
DOI: 10.1016/j.bbr.2011.10.014
关键词
Food intake; Eating; Ingestive behavior; Ventral striatum; NeuN
资金
- National Institute of Diabetes and Digestive and Kidney Diseases [R01DK071738]
- National Science Foundation [0641943]
- National Institute for Drug Abuse [R03DA020802]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [0641943] Funding Source: National Science Foundation
Pronounced feeding can be elicited by injections of the GABA(A) agonist muscimol into the medial shell region of the nucleus accumbens (AcbSh). This region of AcbSh has been shown to project to both the lateral hypothalamus (LH) and the medial ventral pallidum (VPm). The current study examined the effects of unilateral LH or VPm lesions on the ingestive responses induced by injections of muscimol into the AcbSh on either the same or the opposite side of the brain. We found that lesions of either of these structures drastically attenuated feeding induced from the ipsilateral, as compared to the contralateral, AcbSh. The ipsilateral/contralateral disruption design employed here virtually rules out the possibility that the suppressive effects of the lesions were nonspecific and suggests that the VPm and LH play essential roles in mediating the ingestive effects of inactivation of the AcbSh. (C) 2011 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据