Article
Multidisciplinary Sciences
Mayumi Kataoka, Megumi Hazumi, Kentaro Usuda, Emi Okazaki, Daisuke Nishi
Summary: A study of 6015 COVID-19 survivors found that individuals with preexisting psychiatric disorders have an increased risk of experiencing post-COVID-19 symptoms, and this risk may persist even as time passes.
SCIENTIFIC REPORTS
(2023)
Article
Behavioral Sciences
Thomas S. Cotrone, Charina B. Hocog, Joseph T. Ramsey, Marcus A. Sanchez, Heather M. Sullivan, Angus G. Scrimgeour
Summary: Psychological trauma alters the expression of pro-inflammatory and anti-inflammatory markers in microglia, as shown in a rat model study. Fear conditioning and extinction experiments further demonstrate the impact of trauma on fear resolution and immunological phenotype. Future research should focus on understanding the mechanistic role of microglia in PTSD pathology.
BRAIN AND BEHAVIOR
(2021)
Review
Chemistry, Medicinal
Chen-Cheng Lin, Yia-Ping Liu
Summary: Post-traumatic stress disorder (PTSD) is a clinical mental abnormality characterized by symptoms such as flashbacks, nightmares, and uncontrollable thoughts. This article reviews pharmacological interventions for adjusting abnormal fear memory and explores the roles of central monoaminergic systems and the hypothalamic-pituitary-adrenal (HPA) axis. Understanding these mechanisms may provide valuable insights for clinicians managing PTSD.
Article
Pharmacology & Pharmacy
Ling Chen, Kaiping Liu, Yulu Wang, Na Liu, Minjie Yao, Jinlan Hu, Gang Wang, Yindi Sun, Jianchun Pan
Summary: The study showed that the PDE2 inhibitor Bay 60-7550 reversed SPS-induced depression- and anxiety-like behavior and fear memory deficits in mice, and prevented changes in neuroprotective molecules and synaptic proteins.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Psychology, Clinical
Hannah Berg, Yizhou Ma, Amanda Rueter, Antonia Kaczkurkin, Philip C. Burton, Colin G. DeYoung, Angus W. MacDonald, Scott R. Sponheim, Shmuel M. Lissek
Summary: This study focused on the generalization of conditioned-fear in PTSD and its neural correlates within major brain networks. Results indicate that responses in salience (SN), central executive (CEN), and default networks (DN) fall along generalization gradients, with levels of generalization scaling with PTSD symptom severity. These findings suggest that levels of generalization in SN and CEN could serve as promising neural markers of PTSD.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Neurosciences
Gary B. Kaplan, Gabrielle A. Lakis, Hryhoriy Zhoba
Summary: This review emphasizes the significance of the orexin neural system in the pathophysiology of PTSD. Orexinergic neurons play a crucial role in fear behaviors, sleep disturbances, and stress responses. Activation of the orexin system is associated with increased fear expression, impaired sleep, and heightened stress.
BRAIN RESEARCH BULLETIN
(2022)
Article
Psychology, Clinical
Anna Devlin, Sara Casey, Scott Williams, Melita J. Giummarra
Summary: This study examined the relationship between post-traumatic stress symptoms (PTSS) and pain disability. Results showed that individuals with probable PTSD exhibited higher levels of fear avoidance, but did not differ significantly in terms of self-efficacy, pain severity, or disability. There was an indirect association between PTSS and pain disability through fear avoidance, but not through self-efficacy.
JOURNAL OF HEALTH PSYCHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Christiaan H. Vinkers, Elbert Geuze, Sanne J. H. van Rooij, Mitzy Kennis, Remmelt R. Schur, Danny M. Nispeling, Alicia K. Smith, Caroline M. Nievergelt, Monica Uddin, Bart P. F. Rutten, Eric Vermetten, Marco P. Boks
Summary: This study showed that successful treatment of PTSD is associated with significant changes in DNA methylation of certain genes, such as ZFP57. The longitudinal evidence suggests that ZFP57 methylation plays a role in both the development and successful treatment of deployment-related PTSD.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Jimeng Li, Lei Tong, Bettina C. Schock, Li-Li Ji
Summary: Post-traumatic stress disorder (PTSD) is closely related to neuroinflammation, which plays a key role in the pathogenesis of PTSD. Activation of immune cells and changes in inflammatory markers in the brain are involved in neuroinflammation. Understanding the mechanisms of neuroinflammation in PTSD is crucial for studying the disorder.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Behavioral Sciences
Christopher Reist, Tanja Jovanovic, Diana Kantarovich, Leah Weingast, Michael Hollifield, Mahmood Novin, Sakineh Khalaghizadeh, Behrouz Jafari, Renie George, Manessa Riser, Jessica Woodford, Seth D. Norrholm
Summary: Patients with obstructive sleep apnea (OSA) showed significant improvements in fear acquisition, inhibition, and extinction after continuous positive airway pressure (CPAP) therapy. More severe OSA patients were more likely to show enhanced fear inhibition and extinction after CPAP usage. Patients with OSA and co-morbid posttraumatic stress disorder (PTSD) displayed impairments in discriminating between reinforced and nonreinforced conditioned stimuli, fear inhibition, and fear extinction, suggesting the need to address disrupted sleep prior to PTSD exposure therapies.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Clinical Neurology
Inbal Reuveni, Noa Herz, Tuvia Peri, Shaul Schreiber, Yuval Harpaz, Ruth Geisser, Omer Bonne, Abraham Goldstein
Summary: This study investigated the oscillatory brain activity of PTSD patients during recollection and imagination of traumatic memories using magnetoencephalography (MEG). The results showed that PTSD patients exhibited a distinct neural pattern in response to trauma scripts compared to healthy trauma-exposed individuals.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Cell Biology
Vittoria Borgonetti, Bryan Cruz, Valentina Vozella, Sophia Khom, Michael Q. Steinman, Ryan Bullard, Shannon D'Ambrosio, Christopher S. Oleata, Roman Vlkolinsky, Michal Bajo, Eric P. Zorrilla, Dean Kirson, Marisa Roberto
Summary: This study investigated the neuroimmune pathways of post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) in a rat model. The results showed that stress affected the expression of interleukin 18 (IL-18) system in the central amygdala (CeA) of rats, with a stronger effect observed in females. These findings suggest a potential gender-dependent relationship between stress, alcohol, and CeA.
Article
Biochemistry & Molecular Biology
Ting Mei, Linchuan Ma, Fanzhen Kong
Summary: Growing evidence suggests that NLRP3 inflammasome activation in hippocampus and amygdala is involved in the pathophysiology of PTSD. Previous studies have shown that apoptosis of dorsal raphe nucleus (DRN) contributes to the progression of PTSD. Sodium aescinate (SA) has been found to protect neurons by inhibiting inflammatory response pathways in brain injury, and this study demonstrates its therapeutic effects on PTSD rats. SA inhibits NLRP3 inflammasome activation, reduces apoptosis, improves cognitive function, and alleviates anxiety and depression in PTSD rats. Furthermore, NLRP3 inflammasome activation impairs mitochondria function in DRN, but SA effectively reverses this pathological progression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Bongjun Sur, Sunoh Kwon, Dae-Hyun Hahm, Bombi Lee
Summary: The results of this study suggest that protocatechuic acid (PCA) can improve fear extinction, depression, and anxiety symptoms in rats by modulating the serotonergic nervous system and monoamines. This indicates that PCA may have potential in preventing post-traumatic stress disorder (PTSD).
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Neurosciences
Jiaqi Lu, Chuan Qin, Can Wang, Jia Sun, Huijuan Mao, Jianzi Wei, Xueyong Shen, Yang Chen, Sheng Liu, Xiaoyi Qu
Summary: This study demonstrates that electro-acupuncture treatment can improve anxiety-related behaviors in rats with post-traumatic stress disorder (PTSD) by enhancing the activity of orexin neurons in the lateral hypothalamus, leading to a reduction in anxiety levels.
BRAIN RESEARCH BULLETIN
(2023)
Article
Endocrinology & Metabolism
Huiying Wang, Sa Li, Gilbert J. Kirouac
Review
Behavioral Sciences
Gilbert J. Kirouac
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2015)
Article
Behavioral Sciences
Xinwen Dong, Yonghui Li, Gilbert J. Kirouac
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2015)
Article
Multidisciplinary Sciences
Karen Barnabas, Lin Zhang, Huiying Wang, Gilbert Kirouac, Maria Vrontakis
Article
Anatomy & Morphology
Xiaoyu Chen, Huiying Wang, Zhang Lin, Sa Li, Yonghui Li, Hugo T. Bergen, Maria E. Vrontakis, Gilbert J. Kirouac
BRAIN STRUCTURE & FUNCTION
(2014)
Article
Behavioral Sciences
Xiaoyu Chen, Sa Li, Gilbert J. Kirouac
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2014)
Article
Anatomy & Morphology
Sa Li, Yuxiu Shi, Gilbert J. Kirouac
FRONTIERS IN NEUROANATOMY
(2014)
Article
Multidisciplinary Sciences
Samantha J. Carew, Bandhan Mukherjee, Iain T. K. MacIntyre, Abhinaba Ghosh, Sa Li, Gilbert J. Kirouac, Carolyn W. Harley, Qi Yuan
SCIENTIFIC REPORTS
(2018)
Article
Anatomy & Morphology
Sa Li, Xinwen Dong, Gilbert J. Kirouac
Summary: Neurons in the paraventricular nucleus of the thalamus (PVT) respond to emotionally salient events and project densely to subcortical regions known to mediate adaptive behavioral responses, with recent tracing experiments revealing two intermixed populations of neurons that project to different subcortical regions. These neurons provide collateral innervation to a common set of forebrain regions, suggesting a potential broad regulatory role in influencing responses to physiological and psychological challenges.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Anatomy & Morphology
Gilbert J. Kirouac, Sa Li, Shuanghong Li
Summary: The study suggests that the lateral parabrachial nucleus (LPB) serves as a relay for signals to the paraventricular nucleus of the thalamus (PVT), which is involved in regulating behavior. The LPB contains more PVT projecting neurons than other regions of the brainstem. The paper also discusses the anatomical evidence indicating that the PVT is part of a network of interconnected neurons involved in arousal, homeostasis, and the regulation of behavioral states.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Xinwen Dong, Sa Li, Gilbert J. Kirouac
NEUROBIOLOGY OF STRESS
(2020)
Article
Anatomy & Morphology
Xinwen Dong, Sa Li, Gilbert J. Kirouac
BRAIN STRUCTURE & FUNCTION
(2017)
Article
Behavioral Sciences
Huiying Wang, Sa Li, Gilbert J. Kirouac
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)