Article
Behavioral Sciences
Aleksandra Kosza Koszalka, Klaudia Lustyk, Karolina Pytka
Summary: This review discusses the recent progress in understanding the biological sex differences in cognition and highlights the challenges encountered in such research. It focuses on spatial, recognition, and emotional memory, as well as executive functions such as attention, cognitive flexibility, and working memory.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Behavioral Sciences
Carolina Fonseca de Barros, Leonardo de Oliveira Guarnieri, Lara Monteiro Zanetti Mansk, Ayla Secio-Silva, Felipe Emrich, Maiza Ferreira, Walison Nunes da Silva, Rodrigo Antonio Peliciari-Garcia, Grace Schenatto Pereira, Paula Bargi-Souza
Summary: Hypothyroidism affects memory deficits and circadian rhythm disruption, with the latter having a more pronounced effect on female mice. However, there is no direct evidence linking these two effects.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Alec L. E. Butenas, Rie Ishizawa, Korynne S. Rollins, Masaki Mizuno, Steven W. Copp
Summary: Stimulation of mechanically sensitive channels on sensory endings activates mechanoreflex, and capsaicin injection reduces the pressor and renal sympathetic nerve response to mechanoreflex activation in male rats but not female rats.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Clinical Neurology
Alexandra N. Trelle, Valerie A. Carr, Edward N. Wilson, Michelle S. Swarovski, Madison P. Hunt, Tyler N. Toueg, Tammy T. Tran, Divya Channappa, Nicole K. Corso, Monica K. Thieu, Manasi Jayakumar, Ayesha Nadiadwala, Wanjia Guo, Natalie J. Tanner, Jeffrey D. Bernstein, Celia P. Litovsky, Scott A. Guerin, Anna M. Khazenzon, Marc B. Harrison, Brian K. Rutt, Gayle K. Deutsch, Frederick T. Chin, Guido A. Davidzon, Jacob N. Hall, Sharon J. Sha, Carolyn A. Fredericks, Katrin Andreasson, Geoffrey A. Kerchner, Anthony D. Wagner, Elizabeth C. Mormino
Summary: The study found that in cognitively unimpaired older adults, age and lower A beta(42)/A beta(40) were associated with elevated p-tau181, while CSF A beta(42), A beta(40), and p-tau181 were each associated with poorer associative memory and diminished improvement in mnemonic discrimination performance across levels of decreased task difficulty. P-tau mediated the effect of A beta(42)/A beta(40) on memory.
Article
Computer Science, Information Systems
Jun-Gi Jang, Sooyeon Shim, Vladimir Egay, Jeeyong Lee, Jongmin Park, Suhyun Chae, U. Kang
Summary: This article proposes an accurate open-set recognition method called ACORN, which captures sequential patterns and spatial locality patterns in memory access to identify unknown workloads. Experiments show that ACORN achieves state-of-the-art accuracy in both unknown class detection and known class classification.
ACM TRANSACTIONS ON KNOWLEDGE DISCOVERY FROM DATA
(2023)
Article
Behavioral Sciences
Arjan Blokland, Thibaut Sesia
Summary: This study compares the delay-dependent forgetting in two tasks in different rat strains and finds differences between them. It suggests that the forgetting curve of a specific strain should be tested before conducting treatment experiments in these tasks.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Computer Science, Information Systems
Ethan Eddy, Evan Campbell, Angkoon Phinyomark, Scott Bateman, Erik Scheme
Summary: The article introduces an open-source Python library, LibEMG, which can be used for offline EMG analysis and online EMG-based interaction development. By eliminating the barriers that require substantial domain expertise, the library provides researchers with an accessible tool to accelerate research and improve reproducibility. By combining expertise from the prosthetics and human-computer interaction communities, it aims to facilitate the exploration of myoelectric control technology.
Article
Behavioral Sciences
Rebecca J. Wilson, Margaret R. Bell, Katherine R. Giordano, Serena Seyburn, Dorothy A. Kozlowski
Summary: Although concussions are extensively studied, subconcussions, which have higher frequency, have received less attention in neurotrauma research. This study established a subconcussion model and investigated the sex differences in the behavioral responses to repeated subconcussions. The results showed that repeat subconcussions can lead to behavioral impairments similar to or worse than those caused by a single concussion, and females and males exhibit distinct patterns of deficits.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biology
Kepu Chen, Yuting Ye, Nikolaus F. Troje, Wen Zhou
Summary: The study provides evidence of the role of oxytocin and vasopressin in subconscious chemosignaling in humans. It shows that chemosensory communications of masculinity and femininity can be blocked by a competitive antagonist of these neuropeptides. Oxytocin modulates the decoding of sex-specific information in a manner that is dose-dependent, nonmonotonic, and contingent upon social proficiency of the recipients.
Article
Biology
Jae-Sang Sim, Won-Seok Lee, Bo-Eun Yoon
Summary: ADHD is a common neurodevelopmental disorder, and NSCs in the SVZ can affect olfactory function. However, the relevance of NSCs in the olfactory bulb to ADHD has not been studied. Our research on Git1-deficient mice revealed impaired olfactory memory in adult male mice, suggesting sex and age dependence. We cultured NSCs from the SVZ and observed distinct cell populations in both sexes and genotypes. This study suggests that altered NSC differentiation in Git1+/- mice may contribute to olfactory dysfunction in ADHD.
Article
Biochemistry & Molecular Biology
Natasha Ivanova, Milena Atanasova, Zlatina Nenchovska, Jana Tchekalarova
Summary: Prenatal stress impairs cognitive function in rats, Piromelatine treatment corrects memory decline in male rats with chronic mild stress. This study aimed to evaluate the effect of chronic treatment with Piromelatine on memory in male and female offspring with a history of prenatal stress (PNS). Results showed that male and female offspring with PNS had reduced memory responses, particularly in the object recognition test (ORT). Piromelatine treatment attenuated the memory impairment and improved spatial memory in male offspring, potentially via the pCREB/CREB pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Andrew G. Woodman, Richard L. Mah, Samantha Kinney, Claudia D. Holody, Alyssa R. Wiedemeyer, Ronan M. N. Noble, Robin D. Clugston, Stephane L. Bourque
Summary: Perinatal iron deficiency alters renal vitamin A metabolism in a sex-dependent manner, resulting in reduced nephron endowment in male offspring. Male offspring exhibit enhanced retinoic acid pathway signaling components, while females show unchanged or decreased expression. These findings highlight the importance of vitamin A in kidney development and the potential long-term effects of perinatal iron deficiency.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Behavioral Sciences
Cristiana Pistono, Amandine Zimmermann, Chloe Morel, Karine Herbeaux, Celine Heraud, Stephanie Dumont-Kientzy, Paul Pevet, Marie-Paule Felder-Schmittbuhl, Chantal Mathis
Summary: The research findings suggest that MT2 plays a key role in mediating the beneficial effects of melatonin on long-term object recognition memory, while MT1 may contribute to the effects on object location memory.
HORMONES AND BEHAVIOR
(2021)
Review
Psychology, Mathematical
Emma M. Russell, Mitchell G. Longstaff, Heather Winskel
Summary: Researchers have been interested in the impact of individual differences on eyewitness memory, with the sex of the eyewitness being an important factor. There has been inconsistent findings regarding whether sex differences exist in eyewitness memory. However, the research suggests that neither males nor females have superior performance in the total amount of accurate information reported, but rather that females may have better memory for person-related details while males may perform better for details related to the surrounding environment. The own-gender bias was also consistently found.
PSYCHONOMIC BULLETIN & REVIEW
(2023)
Article
Pharmacology & Pharmacy
Skyler Younger, Sydney Boutros, Francesca Cargnin, Shin Jeon, Jae W. Lee, Soo-Kyung Lee, Jacob Raber
Summary: FOXG1 syndrome is a rare and devastating neurodevelopmental disorder characterized by various symptoms. Mouse models with Foxg1 gene mutation displayed phenotypes similar to symptoms of human FS individuals, including anxiety, cognitive impairments, and fear memory deficits.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Alice Bliznyuk, Ben Aviner, Hava Golan, Michael Hollmann, Yoram Grossman
EUROPEAN JOURNAL OF NEUROSCIENCE
(2015)
Article
Clinical Neurology
Chava Zuckerman, Elinor Blumkin, Osnat Melamed, Hava M. Golan
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Genetics & Heredity
Sitvanit Haziza, Roberta Magnani, Dima Lan, Omer Keinan, Ann Saada, Eli Hershkovitz, Nurit Yanay, Yoram Cohen, Yoram Nevo, Robert L. Houtz, Val C. Sheffield, Hava Golan, Ruti Parvari
Article
Neurosciences
Haya Nisimov, Ayelet Orenbuch, Samuel J. Pleasure, Hava M. Golan
Article
Behavioral Sciences
N. Kezurer, D. Galron, H. M. Golan
BEHAVIOURAL BRAIN RESEARCH
(2013)
Article
Spectroscopy
Alexandra Chapsky, Osnat Melamed, Dalia Galron, Hava M. Golan, Ilana Bar
JOURNAL OF RAMAN SPECTROSCOPY
(2012)
Article
Neurosciences
Osnat Melamed, Tamar Levav-Rabkin, Chava Zukerman, Gerard Clarke, John F. Cryan, Timothy G. Dinan, Yoram Grossman, Hava M. Golan
Article
Behavioral Sciences
Noa Sadigurschi, Hava M. Golan
GENES BRAIN AND BEHAVIOR
(2019)
Article
Physiology
Alice Bliznyuk, Hava Golan, Yoram Grossman
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Psychiatry
Galila Agam, Zoe Taylor, Ella Vainer, Hava M. Golan
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Neurosciences
Itay Shekel, Shaked Giladi, Eynav Raykin, May Weiner, Vered Chalifa-Caspi, Dror Lederman, Ora Kofman, Hava M. Golan
Summary: Research suggests that calls emitted by isolated pups may indicate communication deficits and autistic behavior. Changes in pup communication, especially in ASD models, show significant effects on factors such as start and end frequencies, bandwidth, and duration. There are also differences in spectral and temporal properties of calls based on sex and gene/environment factors.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Rotem Tal-Ben Ishay, Apurba Shil, Shirley Solomon, Noa Sadigurschi, Hadeel Abu-Kaf, Gal Meiri, Hagit Flusser, Analya Michaelovski, Ilan Dinstein, Hava Golan, Nadav Davidovitch, Idan Menashe
Summary: WES is an effective approach to identify the susceptibility of genetic variants of autism spectrum disorder (ASD). This study applied WES to a population-based sample of Bedouin and Jewish children with ASD in southern Israel, and found a diagnostic yield of 15.4%. The most cost-effective genetic testing method was chromosomal microarray analysis (CMA).
Article
Multidisciplinary Sciences
Ayelet Arazi, Judah Koller, Ditza A. Zachor, Ofer Golan, Yair Sadaka, Dganit Eytan, Orit Stolar, Naama Atzaba-Poria, Hava Golan, Idan Menashe, Gal Meiri, Lidia V. Gabis, Ilan Dinstein
Summary: Studies have shown that Covid-19 home-quarantine periods have had negative psychological impacts on children with ASD and their families. However, for parents, this period also presented opportunities for improving family relationships and parenting skills.
Meeting Abstract
Clinical Neurology
I. Menashe, I. Dinstein, A. Michaelovski, H. Fluser, M. Ilan, M. Faroy, A. Bar-Sinai, S. Doitch, M. Cohen, N. Davidovitch, H. Golan, S. Arbel, G. Meiri
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Psychology, Developmental
Gal Meiri, Ilan Dinstein, Analya Michaelowski, Hagit Flusser, Michal Ilan, Michal Faroy, Asif Bar-Sinai, Liora Manelis, Dana Stolowicz, Lili Lea Yosef, Nadav Davidovitch, Hava Golan, Shosh Arbelle, Idan Menashe
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2017)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)