Article
Chemistry, Applied
Mohammed Ajebli, Mohamed Eddouks
Summary: The study demonstrates that the aqueous extract of Eucalyptus globulus leaves can reduce blood pressure in hypertensive rats by activating nitric oxide production to relax aortic rings. Furthermore, AEEG shows potential as an antihypertensive agent to reduce the burden of cardiovascular complications.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Esther Oluwasola Aluko, Victor Udo Nna, Adesoji Adedipe Fasanmade
Summary: The present study investigated the effect of ACE inhibitor on fasting blood glucose level in hypertension induced by the inhibition of NOS. The results showed that ACE inhibitor potentiated the hypoglycaemic effect of NOS inhibitor.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yung-Mei Chao, Hana Rauchova, Julie Y. H. Chan
Summary: This study aimed to investigate the role of tissue oxidative stress in the rostral ventrolateral medulla (RVLM) in age-dependent susceptibility to hypertension. The results showed that systemic L-NAME treatment caused age-related increases in blood pressure and sympathetic neurogenic vasomotor activity, accompanied by enhanced oxidative stress in RVLM. This oxidative stress may contribute to the heightened susceptibility of adult rats to L-NAME-induced hypertension.
Article
Biochemistry & Molecular Biology
Foteini Vartzoka, Elif Ozenoglu, Nikolaos Pitsikas
Summary: Multiple lines of evidence suggest that the lack of nitric oxide (NO) is associated with the development of schizophrenia. A compound called molsidomine, which can restore NO levels, may be useful for treating this disorder. This study aimed to investigate the effectiveness of molsidomine and its combination with non-typical antipsychotics clozapine and risperidone in countering memory deficits caused by dysregulation of the brain's dopaminergic system in rats.
Article
Biochemistry & Molecular Biology
Ekaterina K. Selivanova, Anastasia A. Shvetsova, Anna A. Borzykh, Dina K. Gaynullina, Oxana O. Kiryukhina, Elena Lukoshkova, Viktoria M. Potekhina, Vladislav S. Kuzmin, Olga S. Tarasova
Summary: Nitric oxide (NO) has been shown to have a stimulating effect on differentiation and survival of ganglionic sympathetic neurons. Intrauterine NO deficiency may weaken the development of vascular sympathetic innervation and alter the contractility of peripheral arteries and blood pressure level in offspring. The impaired sympathetic nervous system development in early postnatal life, accompanied by structural and functional remodeling of arterial blood vessels, is observed in offspring exposed to L-NAME in utero.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Isabel T. N. Nguyen, Lucas M. Wiggenhauser, Marian Bulthuis, Jan-Luuk Hillebrands, Martin Feelisch, Marianne C. Verhaar, Harry van Goor, Jaap A. Joles
Summary: This study found that Sodium Thiosulfate can improve heart disease induced by L-NNA in an experimental hypertension model, including ameliorating hypertension and cardiac dysfunction, as well as having antioxidant properties and preventing cardiac fibrosis. Its protective effects were similar to lisinopril, but there was no added benefit when the two were combined for heart disease protection.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Mohammad-Reza Zarrindast, Soheila Fazli-Tabaei, Fatemeh Khakpai
Summary: In PD mice, both dopamine D2 receptor and nitric oxide (NO) mechanisms have an impact on anxiety and memory. L-NAME reversed the anxiogenic and memory improvement effect induced by sulpiride. The anxiolytic and amnesic effects caused by quinpirole were reversed by L-arginine. There is a synergistic effect between dopamine D2 receptor and NO systems in modulating anxiety and memory.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Clinical Neurology
Amelie Descheemaeker, Herve Poras, Michel Wurm, Philippe Luccarini, Tanja Ouimet, Radhouane Dallel
Summary: The dual enkephalinase inhibitor PL37 has shown potential as an acute and prophylactic treatment for migraine, as demonstrated in animal pain models and early human clinical trials. Protecting enkephalins from degradation appears to be an innovative approach for migraine treatment.
Article
Multidisciplinary Sciences
Hongyuan Zhang, Zhiqiang Zhao, Shengnan Sun, Sen Zhang, Yuequan Wang, Xuanbo Zhang, Jin Sun, Zhonggui He, Shenwu Zhang, Cong Luo
Summary: In this study, the authors developed a self-propelling nano-penetrator assembled with a photothermal photosensitizer and a photothermal-activable NO donor. The nano-penetrator showed advantages in terms of NO productivity and autonomous motion under laser irradiation. In animal models, it successfully navigated to thrombus, penetrated deep into the clot, and achieved effective thrombolysis and prevention of thrombosis recurrence and ischemic stroke.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Stanislava Vrankova, Zuzana Galandakova, Jakub Benko, Martina Cebova, Igor Riecansky, Olga Pechanova
Summary: The results of the study indicate that 10 weeks of social isolation led to a significant decrease in PPI, accompanied by a decrease in NOS activity in the cerebral cortex and the cerebellum, an increase in iNOS in the hippocampus, and an increase in CD concentration in cortex homogenate. On the other hand, 29 weeks of social isolation had an opposite effect on NOS activity, with an increase in the cerebral cortex and the cerebellum in animals reared in a social environment, accompanied by a decrease in CD concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Marcelo P. M. Adelino, Marcel V. Nunes, Marielle F. Q. Nunes, Edivarley R. Costa Jr, Elias Ajub, Milan P. B. Mitrovitch, Juliana M. Ushirohira, Lucas C. Quarantini, Jaime C. E. Hallak, Acioly L. T. Lacerda
Summary: This study evaluated the efficacy of repeated-dose SNP in treatment-resistant schizophrenia, and found that SNP was not efficacious in TRS, consistent with previous studies. The findings suggest that the efficacy of SNP may be limited to early stages of the disease.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Nutrition & Dietetics
Aleksandra Szlas, Jakub Michal Kurek, Zbigniew Krejpcio
Summary: L-arginine is a safe endogenous amino acid involved in various regulatory functions in the body. It may be helpful in managing disturbed metabolism, regulating blood pressure, and alleviating type 2 diabetes symptoms, but the mechanisms underlying these effects are not fully understood.
Article
Pharmacology & Pharmacy
Mohd Khairulanwar Bunaim, Yusof Kamisah, Mohd Noor Mohd Mustazil, Japar Sidik Fadhlullah Zuhair, Abdul Hamid Juliana, Norliza Muhammad
Summary: The study showed that C. asiatica extract has antihypertensive and cardioprotective effects in a hypertensive rat model induced by l-NAME, preventing the development of hypertension and cardiac damage. The effects were comparable to captopril.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pediatrics
Noriyuki Nakamura, Takafumi Ushida, Atsuto Onoda, Kazuto Ueda, Ryosuke Miura, Toshihiko Suzuki, Satoru Katsuki, Hidesuke Mizutani, Kosuke Yoshida, Sho Tano, Yukako Iitani, Kenji Imai, Masahiro Hayakawa, Hiroaki Kajiyama, Yoshiaki Sato, Tomomi Kotani
Summary: The neurodevelopment of rat offspring in a preeclampsia model induced by L-NAME was evaluated, and unique protein signatures were identified in the offspring's cerebrospinal fluid, shedding light on the mechanism underlying the increased risk of subsequent neurodevelopmental disorders in children born to mothers with preeclampsia.
FRONTIERS IN PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Nehal S. Alsharif, Tom Clifford, Abrar Alhebshi, Samantha N. Rowland, Stephen J. Bailey
Summary: Inorganic nitrate (NO3-) has shown potential as an ergogenic aid in enhancing performance during high-intensity exercise. This review analyzed 27 studies and conducted a meta-analysis, which found that NO3- supplementation improved time to reach peak power, mean power output, and total distance covered in the Yo-Yo intermittent recovery level 1 test. These findings suggest that athletes participating in high-intensity exercise may benefit from NO3- supplementation.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)