期刊
BEHAVIOURAL BRAIN RESEARCH
卷 217, 期 2, 页码 477-480出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2010.10.022
关键词
Operant; Mechanical; Thermal; Orofacial; Pain; Hyperalgesia; Allodynia; Analgesia
资金
- National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA [2R44DA026220-02A1]
- National Institute of Neurological Disorders and Stroke [T32NS045551]
Mechanical pain sensitivity is characteristic of many orofacial pain conditions; however, few models exist to quantify this pain. Here we evaluated a novel adaptation of our existing operant system to characterize orofacial pain following mechanical and thermal stimuli. We demonstrate that the operant system is able to detect painful and analgesic responses to mechanical stimuli. These findings allow comparison of both mechanical and thermal stimuli using the same outcome measures. (C) 2010 Elsevier B.V. All rights reserved.
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