Article
Medicine, Research & Experimental
Fateme Khodabande, Esmaeil Akbari, Motahareh Rouhi Ardeshiri
Summary: The orexin 1 receptors in the dorsal raphe nucleus play a significant role in the consolidation of spatial reference memory in rats, while the orexin 2 receptors do not have an effect.
Article
Neurosciences
Lisa Wintzell, Samuel Klemetz, Stefan Lange, Eric Hanse, Caroline Wass, Joakim Strandberg
Summary: The endogenous peptide antisecretory factor (AF) enhances long-term potentiation (LTP) and spatial learning and memory by disinhibiting GABAergic transmission in the rat hippocampus.
Article
Multidisciplinary Sciences
Gregory D. Clemenson, Antonella Maselli, Alexander J. Fiannaca, Amos Miller, Mar Gonzalez-Franco
Summary: GPS navigation has become commonplace in everyday life, but traditional turn-by-turn navigation may promote passive spatial navigation and poor spatial learning. An alternative form of GPS navigation based on sensory augmentation, using a 3D spatial audio system, is proposed to encourage users to take a more active role in their spatial navigation for a better understanding of the explored environment.
SCIENTIFIC REPORTS
(2021)
Article
Behavioral Sciences
Amanda Dyer, Maxine De Butte
Summary: This study aimed to examine the effects of chronic low-dose vanadium administration on the behavior of young male rats. The findings suggest that vanadium does not significantly affect exploration, locomotion, or anxiety-like behavior in rats, but does affect novel object recognition performance. Additionally, vanadium administration led to lower latency times in the Morris Water maze task.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Ewa Zwierzynska, Boguslawa Pietrzak
Summary: Lacosamide does not impair memory and learning processes, with temporary disruption of emotional memory observed only after a single high dose administration.
EPILEPSY & BEHAVIOR
(2021)
Review
Behavioral Sciences
Lucia Amendola, Daniel Weary, Gosia Zobel
Summary: Individual variation in responses to anxiety and spatial memory tests is often reported. These variations are related to consistent individual differences in behavior (personality). However, personality differences are rarely considered in anxiety treatment studies. This article focuses on rat literature to describe principles in anxiety and spatial memory tests and discusses the influence of personality and housing conditions on behavioral responses. The authors propose that environmental enrichment can enhance stress resiliency in environmentally sensitive individuals. Incorporating personality measures into study design and analysis can improve research reproducibility.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Jemi Feiona Vergil Andrews, Divya Bharathi Selvaraj, Akshay Kumar, Syed Aasish Roshan, Muthuswamy Anusuyadevi, Mahesh Kandasamy
Summary: This study investigated the effect of aspirin on spatial memory in ageing experimental mice. Aspirin was found to enhance working memory, increase the number of new neurons in the hippocampus, reduce the number of microglial cells, and decrease the activity of AChE in the blood.
Article
Neurosciences
Keyvan Mehri, Zohreh Zavvari Oskuye, Ehsan Nassireslami, Esmail Karami, Mohammad Reza Parvizi
Summary: This study investigated the effects of Botulinum toxin on spatial memory and biochemical and histological parameters in the hippocampus of male rats. Results showed that Botox significantly impaired memory performance and led to a decrease in acetylcholine levels, increase in acetylcholinesterase activity, and morphological damage in the hippocampus. Administration of Rivastigmine partially alleviated these effects and could serve as a protective approach.
Article
Neurosciences
David A. Cinalli, Sarah J. Cohen, Mariah Calubag, Goksu Oz, Lylybell Zhou, Robert W. Stackman
Summary: This study used the DREADDs method to investigate the effects of CA1 pyramidal neurons in the hippocampus on the retrieval of long-term memory for nonspatial and spatial information in mice. The results showed that the inhibition of CA1 neuronal activity significantly impaired the memory retrieval in mice. These findings support the use of mice as a model system to study the neurobiological mechanisms of human episodic memory.
Article
Behavioral Sciences
Niklas Lonnemann, Martin Korte, Shirin Hosseini
Summary: Alzheimer's disease is a neurodegenerative disease with no successful treatment. In addition to its features, neuroinflammatory processes, genetic factors, and lifestyle also play important roles. Training in a water maze has shown positive effects on memory formation in AD mice.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Burak Tan, Umut Bakkaloglu, Meral Ascioglu, Cem Suer
Summary: This study found that thyroid hormone excessiveness during perinatal period can lead to long-lasting effects on hippocampal function, with differences in behavior and molecular indicators between rats treated with l-thyroxine during maternal period and in young adulthood. These effects may contribute to memory problems observed in adolescents with lactational hyperthyroidism.
PHARMACOLOGICAL REPORTS
(2021)
Article
Pharmacology & Pharmacy
Huma Ikram, Rabia Masood, Shazia Syed, Darakhshan Jabeen Haleem
Summary: Dose dependent effects of pioglitazone on memory revival and monoamine metabolism were monitored in this study. Rats were treated with three doses of pioglitazone i.e., 5, 10 and 15mg/kg and effects were monitored in various tests. Results show memory enhancing effects of pioglitazone at all three doses, but these effects were potentiated at the dose of 10mg/kg. Pioglitazone also exhibited anxiolytic and antidepressant effects. The study also investigated the effect of pioglitazone on dopamine metabolism.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bettina Reka Laszlo, Erika Kertes, Tamas Ollmann, Laszlo Peczely, Anita Kovacs, Zoltan Karadi, Laszlo Lenard, Kristof Laszlo
Summary: The neurotransmitter and neuromodulator neurotensin (NT) has been found to facilitate spatial learning and memory through the activation of DA D2 receptors in the central nucleus of amygdala (CeA).
Article
Multidisciplinary Sciences
Manuel G. Forero, Natalia C. Hernandez, Cristian M. Morera, Luis A. Aguilar, Ruth Aquino, Laura E. Baquedano
Summary: The paper developed a new image processing technique called RatsTrack to automatically analyze the track of the rat in the MWM. RatsTrack successfully detected and located the pool and rat without user intervention, significantly decreasing operational time and providing results for distance, time, speed, and acceleration parameters of the MWM test.
Article
Multidisciplinary Sciences
Franka Gloeckner, Nicolas W. Schuck, Shu-Chen Li
Summary: According to the study, spatial learning can be based on intramaze cues and environmental boundaries, and these two modes of learning show different developmental trends in different age groups. Intramaze cue-based learning matures earlier during childhood and remains relatively stable, while boundary-based learning develops more slowly towards late adolescence and declines significantly during aging.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Olga Zagoracz, Tamas Ollmann, Laszlo Peczely, Kristof Laszlo, Anita Kovacs, Beata Berta, Veronika Kallai, Erika Kertes, Laszlo Lenard
Article
Behavioral Sciences
Veronika Kallai, Laszlo Lenard, Laszlo Peczely, Rita Galosi, Daniella Dusa, Attila Toth, Kristof Laszlo, Erika Kertes, Anita Kovacs, Olga Zagoracz, Beata Berta, Zoltan Karadi, Tamas Ollmann
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Lauren M. Slosky, Yushi Bai, Krisztian Toth, Caroline Ray, Lauren K. Rochelle, Alexandra Badea, Rahul Chandrasekhar, Vladimir M. Pogorelov, Dennis M. Abraham, Namratha Atluri, Satyamaheshwar Peddibhotla, Michael P. Hedrick, Paul Hershberger, Patrick Maloney, Hong Yuan, Zibo Li, William C. Wetsel, Anthony B. Pinkerton, Lawrence S. Barak, Marc G. Caron
Article
Behavioral Sciences
Laszlo Peczely, Gabriella Kekesi, Veronika Kallai, Tamas Ollmann, Kristof Laszlo, Alexandra Biki, Laszlo Lenard, Gyongyi Horvath
Summary: The activation of VP D2 receptors in Wistar rats induces symptoms similar to those observed in schizophrenia model Wisket rats. Wisket rats show impaired food-related motivation, but treatment with quinpirole does not lead to further deterioration.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kristof Laszlo, Orsolya Kiss, David Voros, Kitti Mintal, Tamas Ollmann, Laszlo Peczely, Anita Kovacs, Olga Zagoracz, Erika Kertes, Veronika Kallai, Bettina Laszlo, Edina Hormay, Beata Berta, Attila Toth, Zoltan Karadi, Laszlo Lenard
Summary: In this study, the potential anxiolytic effect of oxytocin (OT) in the amygdala was investigated using the elevated plus maze test in a rodent model of autism induced by valproate (VPA). The results showed that bilateral OT microinjection into the central nucleus of the amygdala reduced anxiety levels in autistic rats.
Article
Clinical Neurology
Laszlo Peczely, Tamas Ollmann, Kristof Laszlo, Laszlo Lenard, Anthony A. Grace
Summary: Quinpirole dose dependently regulates VTA dopaminergic activity and influences motivation and motor behavior in rats at the level of the ventral pallidum.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Kitti Mintal, Attila Toth, Edina Hormay, Anita Kovacs, Kristof Laszlo, Anita Bufa, Tamas Marosvolgyi, Bela Kocsis, Adorjan Varga, Zoltan Vizvari, Renata Cserjesi, Laszlo Peczely, Tamas Ollmann, Laszlo Lenard, Zoltan Karadi
Summary: The prevalence of autism spectrum disorder (ASD) has increased rapidly in recent decades, potentially due to the excessive use of antibiotics and consequent disruption of the gastrointestinal microbiome. This study used an animal model to demonstrate that depletion of the gastrointestinal microbiome via antibiotics treatment can induce ASD-like behavioral symptoms in adulthood. Additionally, a probiotic mixture (PM) developed by the research team showed potential in attenuating these symptoms.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Kristof Laszlo, David Voros, Orsolya Kiss, Bettina Reka Laszlo, Tamas Ollmann, Laszlo Peczely, Kitti Mintal, Attila Toth, Anita Kovacs, Olga Zagoracz, Erika Kertes, Veronika Kallai, Beata Berta, Zoltan Karadi, Laszlo Lenard
Summary: This study found that oxytocin injected into the central nucleus of the amygdala has positive reinforcing effects in a rat model of autism induced by valproate. The effects are specific to oxytocin receptors and are blocked by a dopamine D2 receptor antagonist. The findings suggest a potential role for oxytocin and the dopaminergic system in the treatment of autism.
Article
Biochemistry & Molecular Biology
Tamas Ollmann, Laszlo Lenard, Laszlo Peczely, Beata Berta, Erika Kertes, Olga Zagoracz, Edina Hormay, Kristof Laszlo, Adam Szabo, Rita Galosi, Zoltan Karadi, Veronika Kallai
Summary: The present study demonstrates that the rewarding and anxiolytic effects of NT in the VP depend on the activity of D1-like and D2-like DA receptors, and antagonists can block these effects.
Article
Biochemistry & Molecular Biology
Bettina Reka Laszlo, Erika Kertes, Tamas Ollmann, Laszlo Peczely, Anita Kovacs, Zoltan Karadi, Laszlo Lenard, Kristof Laszlo
Summary: The neurotransmitter and neuromodulator neurotensin (NT) has been found to facilitate spatial learning and memory through the activation of DA D2 receptors in the central nucleus of amygdala (CeA).
Article
Biochemistry & Molecular Biology
David Voros, Orsolya Kiss, Tamas Ollmann, Kitti Mintal, Laszlo Peczely, Olga Zagoracz, Erika Kertes, Veronika Kallai, Bettina Reka Laszlo, Beata Berta, Attila Toth, Laszlo Lenard, Kristof Laszlo
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects a significant portion of children worldwide. Impaired social interaction is a core symptom of ASD and finding effective treatments is crucial. This study investigated the impact of oxytocin (OT) on social interaction in a rat model of ASD induced by valproate (VPA). The results demonstrated that intraamygdaloid OT increased social interaction time in VPA-treated rats, suggesting its potential as a therapeutic intervention for ASD.
Article
Multidisciplinary Sciences
Daniella Dusa, Tamas Ollmann, Veronika Kallai, Laszlo Lenard, Erika Kertes, Beata Berta, Adam Szabo, Kristof Laszlo, Rita Galosi, Olga Zagoracz, Zoltan Karadi, Laszlo Peczely
Summary: Sulpiride, a D2R antagonist, has been found to modulate learning processes and induce rewarding effects when microinjected into the VP. However, animals are unable to associate the rewarding effect with spatial locations.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
