期刊
BEHAVIOURAL BRAIN RESEARCH
卷 198, 期 2, 页码 472-476出版社
ELSEVIER
DOI: 10.1016/j.bbr.2008.11.036
关键词
Antidepressant; Neurosteroids; Sigma-1; Forced swim
资金
- National Institutes of Health [5K99AA016731-02, 1T32NS061847-01A2]
Activation of sigma-1 receptors (Sig-1R) reportedly has antidepressant-like action. Limited data suggest that Sig-1Rs also modulate anxiety-related behaviors. The present experiments measured depressive-like, anxiety-like and motor behavior in Sig-1R knockout mice and their wildtype littermates. Sig-1R knockout mutants showed increased immobility in the forced swimming test, a depressive-like phenotype, but normal anxiety-like behavior in the elevated plus-maze and light/dark box tests and normal locomotor activity. The results further suggest that Sig-1Rs inversely modulate depressive-like behavior. (C) 2008 Elsevier B.V. All rights reserved.
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