Article
Biochemistry & Molecular Biology
Tiziana Schioppa, Hoang Oanh Nguyen, Laura Tiberio, Francesca Sozio, Carolina Gaudenzi, Mauro Passari, Annalisa Del Prete, Daniela Bosisio, Valentina Salvi
Summary: This study investigated the effects of HDIs on TNFAIP3 expression and identified two distinct mechanisms of action: direct inhibition through HDAC blockade and indirect decrease via TNF-α induction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Joanna Kowalczyk, Modestos Nakos-Bimpos, Alexia Polissidis, Christina Dalla, Nikolaos Kokras, Krystyna Skalicka-Wozniak, Barbara Budzynska
Summary: This study found that xanthotoxin can reduce depressive behaviors in male mice, while female mice have lower immobility levels compared to males, which may be related to higher levels of serotonin in the female prefrontal cortex. Additionally, xanthotoxin can lead to a dose-dependent increase in serotonin and noradrenaline levels in the female prefrontal cortex.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Cell Biology
Robert L. Murray, Wei Zhang, Jianan Liu, Jason Cooper, Alex Mitchell, Maria Buman, Jiuzhou Song, Chad H. Stahl
Summary: Satellite cells are muscle resident stem cells responsible for muscle growth and repair, with histone deacetylase inhibitors showing potential in enhancing their myogenic program. Reduction in EZH2 expression and global chromatin changes were observed in satellite cells treated with the HDAC inhibitor butyrate, indicating a parallel mechanism may exist for butyrate's effects on myogenic differentiation.
Article
Neurosciences
Paulina Misztak, Magdalena Sowa-Kucma, Bernadeta Szewczyk, Gabriel Nowak
Summary: The study evaluated the impact of SAHA on the expression of several key proteins in the brain's signal transduction pathways, as well as the concentration of the oxidative stress product MDA. SAHA may prevent oxidative stress by decreasing MDA concentration and increasing p-AMPK expression, while also boosting neuroprotective and antidepressant protein levels.
NEUROTOXICITY RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Anna Calvi, Ilaria Fischetti, Ignazio Verzicco, Martino Belvederi Murri, Stamatula Zanetidou, Riccardo Volpi, Pietro Coghi, Stefano Tedeschi, Mario Amore, Aderville Cabassi
Summary: Patients with depression who take antidepressant medication may have an increased risk of developing hypertension. Different types of antidepressants have varying effects on blood pressure, with selective serotonin reuptake inhibitors being the safest class, while dopamine-norepinephrine reuptake inhibitors may lead to blood pressure increases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cell Biology
Tien-Wei Hsu, Brendon Stubbs, Chih-Sung Liang, Tien-Yu Chen, Ta-Chuan Yeh, Chih-Chuan Pan, Che-Sheng Chu
Summary: This meta-analysis demonstrates that serotonergic antidepressants effectively alleviate overall neuropsychiatric symptoms, agitation, depressive symptoms, and care burden in patients with dementia, as well as improving cognitive function.
AGEING RESEARCH REVIEWS
(2021)
Article
Clinical Neurology
Martin J. Lan, Francesca Zanderigo, Spiro P. Pantazatos, M. Elizabeth Sublette, Jeffrey Miller, R. Todd Ogden, J. John Mann
Summary: Disturbance of serotonin system function is associated with both the diagnosis of BD and its severity of depression. Pretreatment 5HT1AR binding did not predict SSRI antidepressant outcome.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Immunology
William Yip, Michael R. Hughes, Yicong Li, Alissa Cait, Martin Hirst, William W. Mohn, Kelly M. McNagny
Summary: The gut-lung axis highlights the crucial biological crosstalk between the intestinal microbiome and lung, which may be a driving force behind the development of allergic asthma.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Behavioral Sciences
Paul J. Fitzgerald, Pho J. Hale, Anjesh Ghimire, Brendon O. Watson
Summary: Research indicates that acetylcholinesterase inhibitors exhibit an antidepressant-like effect in mice, showing a U-shaped dose-response curve. Three different AChEIs show therapeutic effects at low doses without causing hyperactivity or anxiolytic effects.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Oncology
Tatsuo Sawai, Koji Yamanegi, Hiroshi Nishiura, Hiroyuki Futani, Toshiya Tachibana
Summary: The study aimed to enhance the expression of SEMA3A in osteosarcoma cells by using histone deacetylase inhibitors, thereby suppressing angiogenesis and inhibiting proliferation and metastasis. The results showed that HDAC inhibitors can increase the expression of SEMA3A and its receptor NRP1, inhibit tumor angiogenesis, and exert anti-angiogenic and anti-tumor effects through the SEMA3A/NRP1/PLXNA1 signaling pathway.
ANTICANCER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Chan Yang, Xiaoyan Pan, Yuan Huang, Chen Cheng, Xinfeng Xu, Yan Wu, Yunxia Xu, Weijuan Shang, Xiaoge Niu, Yihong Wan, Zhaofeng Li, Rong Zhang, Shuwen Liu, Gengfu Xiao, Wei Xu
Summary: The study found that Itraconazole and Estradiol benzoate can inhibit viral entry by targeting the six-helix fusion core of SARS-CoV-2 S protein, presenting them as novel potential therapeutic remedies for COVID-19 treatment. Further research also showed that Itraconazole has broad-spectrum activity targeting 6-HB in the S2 subunit of SARS-CoV and MERS-CoV S protein, suggesting its potential as a pan-coronavirus fusion inhibitor.
ADVANCED THERAPEUTICS
(2021)
Article
Behavioral Sciences
Amanda J. Sales, Samia R. L. Joca, Elaine Del Bel, Francisco S. Guimaraes
Summary: Doxycycline, an antibiotic, has neuroprotective, anti-inflammatory, and antidepressant-like effects. It inhibits the synthesis of nitric oxide and reduces its levels in the prefrontal cortex, leading to rapid antidepressant-like effects in mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Cell Biology
Yichen Zhang, Yutian Lei, Mohsen Honarpisheh, Elisabeth Kemter, Eckhard Wolf, Jochen Seissler
Summary: Butyrate treatment in neonatal porcine islet-like clusters (NPICCs) leads to increased insulin gene expression and beta cell number, potentially mediated through histone deacetylase (HDAC) inhibitory activity. Specific class I HDAC inhibitors mimic the effects of butyrate on beta cell differentiation, suggesting their potential as supplements for promoting differentiation of islet cells towards beta cells in cell replacement therapies.
Article
Biochemistry & Molecular Biology
Toshiya Funatsuki, Haruhiko Ogata, Hidetoshi Tahara, Akira Shimamoto, Yoshiteru Takekita, Yosuke Koshikawa, Shinpei Nonen, Koichiro Higasa, Toshihiko Kinoshita, Masaki Kato
Summary: Individual responses to antidepressant treatment varies, and understanding the factors contributing to this variability is important. This study investigated the correlation between changes in plasma miRNA levels and treatment outcomes of MIR and SSRI monotherapy in MDD patients. The results suggest that specific miRNAs may serve as potential biomarkers for predicting treatment response in depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Jeffrey R. Strawn, Jeffrey A. Mills, Vikram Suresh, Taryn Mayes, Melanie T. Gentry, Madhukar Trivedi, Paul E. Croarkin
Summary: Understanding how age affects antidepressant response is important for treatment selection. This study analyzed participant-level data from NIH-sponsored trials to identify the impact of age on antidepressant response.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)