Article
Biochemistry & Molecular Biology
Xiang Li, Qi Li, Lisha Xu, Zhe Ma, Yaxin Shi, Xirui Zhang, Yuan Yang, Jia Wang, Lili Fan, Lijie Wu
Summary: Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder characterized by abnormal pain sensation. This study identified Kir4.1 as a key factor in ASD pain sensitivity, and inhibition of Kir4.1 improved pain insensitivity by regulating glutamate transporters EAAT1 and EAAT2. These findings provide a theoretical basis for targeted intervention in ASD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Immunology
Hui Lv, Xiao Gu, Xingyue Shan, Tailin Zhu, Bingke Ma, Hao-Tian Zhang, Victorio Bambini-Junior, Tiantian Zhang, Wei-Guang Li, Xiaoling Gao, Fei Li
Summary: By utilizing nanotechnology, the study found that bumetanide can effectively alleviate social deficits associated with autism spectrum disorder (ASD), specifically within the medial prefrontal cortex (mPFC) region. Furthermore, the therapeutic effect of bumetanide was found to be dependent on microglia targeting in the mPFC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Min Zhao, Qiaoqiao Chang, Hua Yang, Min Wang, Yongfeng Liu, Na Lv, Qiang Lei, Hongen Wei
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social communication and repetitive behaviors. Current treatments are only symptomatic and ineffective. Microtubule stability may be a promising therapeutic target for ASD, and Epothilone D could improve ASD-like behaviors by enhancing microtubule stability.
Article
Oncology
Hye-Yeon Park, Jun Go, Young-Kyoung Ryu, Dong-Hee Choi, Jung-Ran Noh, Jin-Pyo An, Won-Keun Oh, Pyung-Lim Han, Chul-Ho Lee, Kyoung-Shim Kim
Summary: The study found that Humulus japonicus may have therapeutic potential for ASD, ameliorating behavioral deficits and neuroinflammation in ASD mouse models.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Qi Li, Yaxin Shi, Xiang Li, Yuan Yang, Xirui Zhang, Lisha Xu, Zhe Ma, Jia Wang, Lili Fan, Lijie Wu
Summary: Abnormal lipid metabolism is suggested to contribute to the pathogenesis of autism spectrum disorder (ASD). Using proteomic and bioinformatics analysis, this study identified differentially expressed proteins enriched in lipid metabolic pathways in hippocampal tissues of ASD mice. Apolipoprotein A-I (ApoA-I) was found to be significantly upregulated in ASD mice. Further experiments showed that inhibiting the SphK pathway improved ASD core phenotype and related protein levels. Proteins related to neuron synapse development and function were also restored to normal levels in ASD mice. Elucidating the mechanism of ApoA-I in ASD-associated phenotypes may provide new insights into the etiology of ASD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
David J. Fairburn, Brandon A. Baiamonte, Bethany E. Gray, Katherine A. Hernandez, Jade R. Horton, Daniel B. Hollander
Summary: This study examined the effects of physical exercise on nociceptive responses and social interactions in an autism mouse model. The results showed that exercise improved thermal hypoalgesia but did not significantly reduce social interaction deficits in the mice.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Jenika Staben, Megan Koch, Keelee Reid, Jessica Muckerheide, Lauren Gilman, Finn McGuinness, Sarina Kiesser, Iain W. H. Oswald, Kevin A. Koby, Thomas J. Martin, Joshua S. Kaplan
Summary: CBD can enhance social behavior in individuals with ASD, and when used in combination with cannabis terpene blends, it produces a stronger effect.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Mohammed M. Alanazi, Mushtaq A. Ansari, Ahmed Nadeem, Sabry M. Attia, Saleh A. Bakheet, Haneen A. Al-Mazroua, Abdullah A. Aldossari, Mohammed M. Almutairi, Thamer H. Albekairi, Marwa H. Hussein, Mohammed A. Al-Hamamah, Sheikh F. Ahmad
Summary: This study found that cadmium exposure exacerbates self-grooming and marble-burying behaviors, decreases social interactions, and leads to immune abnormalities in an autism spectrum disorder animal model. Further investigation revealed potential molecular mechanisms underlying these effects. These findings have important implications for the etiology of autism spectrum disorders and provide further evidence of heavy metals contributing to neurodevelopmental disorders through proinflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Haneen A. Al-Mazroua, Ahmed Nadeem, Mushtaq A. Ansari, Sabry M. Attia, Thamer H. Albekairi, Saleh A. Bakheet, Abdulelah F. Alobaidi, Khaled Alhosaini, Saleh A. Alqarni, Khalid E. Ibrahim, Abdulaziz M. S. Alsaad, Sheikh F. Ahmad
Summary: This study found that exposure to MeHgCl worsens existing behavioral and immune abnormalities in BTBR mice, causing increased marble burying and self-grooming behaviors, decreased social interactions, and adverse effects on locomotor activity.
IMMUNOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Article
Neurosciences
Shirin Sharghi, Stefanie Flunkert, Magdalena Daurer, Roland Rabl, Boris Philippe Chagnaud, Marcello Leopoldo, Enza Lacivita, Birgit Hutter-Paier, Manuela Prokesch
Summary: Autism spectrum disorder (ASD) is characterized by impaired social communication and repetitive behavior, and its causes are still unclear. In this study, the GABA(B) receptor agonist R-Baclofen and the selective agonist for the 5HT(7) serotonin receptor LP-211 were tested on mouse models of ASD. Results showed that both compounds improved social deficits and repetitive behaviors in the mice. However, further studies are needed to evaluate their effectiveness as potential ASD treatments.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna E. Skorzynska-Dziduszko, Agata Makarewicz, Anna Blazewicz
Summary: This study aimed to investigate whether plasma levels of leptin in pre- and post-pubertal children with autism spectrum disorder (ASD) and/or overweightness/obesity differ from those of BMI- and age-matched healthy controls. Leptin levels showed different patterns in ASD children with overweightness/obesity and ASD children with normal BMI. However, there were no significant differences in leptin levels between ASD+ / Ob + and ASD- / Ob + or between ASD + / Ob- and ASD- / Ob- before and after puberty.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Hongmei Wu, Yue Luan, Hongzhi Wang, Pengfei Zhang, Sijin Liu, Peng Wang, Yonggang Cao, Hongli Sun, Lijie Wu
Summary: The study found that sodium selenite (Se) has a positive effect on autism spectrum disorder (ASD) behaviors and inhibits ferroptosis. It acts by modulating the Nrf2/GPx4 signaling pathway.
BRAIN RESEARCH BULLETIN
(2022)
Article
Neurosciences
Mashal M. Almutairi, Ahmed Nadeem, Mushtaq A. Ansari, Saleh A. Bakheet, Sabry M. Attia, Thamer H. Albekairi, Khaled Alhosaini, Mohammad Algahtani, Abdulaziz M. S. Alsaad, Haneen A. Al-Mazroua, Sheikh F. Ahmad
Summary: This study investigated the effects of lead exposure on sociability, repetitive behavior, and neuroimmune function in BTBR mice, a preclinical model for ASD. The results showed that lead exposure increased repetitive behavior and marble burying, decreased social interactions, and affected immune cell populations and gene expression in the spleen and brain tissue.
Article
Biochemistry & Molecular Biology
Mohammed A. Assiri, Thamer H. Albekairi, Mushtaq A. Ansari, Ahmed Nadeem, Sabry M. Attia, Saleh A. Bakheet, Mudassar Shahid, Abdullah A. Aldossari, Mohammed M. Almutairi, Taghreed N. Almanaa, Mohammad Y. Alwetaid, Sheikh F. Ahmad
Summary: Autism spectrum disorder (ASD) is a common neurodevelopmental disorder, and zebrafish is an animal model for studying ASD. Lead (Pb) exposure exacerbates immunological dysfunctions associated with ASD and may increase the risk of ASD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)