Article
Clinical Neurology
Andrea Pilotto, Viviana Cristillo, Stefano Cotti Piccinelli, Nicola Zoppi, Giulio Bonzi, Davide Sattin, Silvia Schiavolin, Alberto Raggi, Antonio Canale, Stefano Gipponi, Ilenia Libri, Martina Frigerio, Michela Bezzi, Matilde Leonardi, Alessandro Padovani
Summary: Long-term neurological manifestations have been observed in both hospitalised and non-hospitalised COVID-19 patients. Factors such as age, comorbidities, and severity of SARS-CoV-2 infection are independent predictors of long-term neurological symptoms in survivors after 6 months of hospitalisation.
NEUROLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Benjamin Compans, Come Camus, Emmanouela Kallergi, Silvia Sposini, Magalie Martineau, Corey Butler, Adel Kechkar, Remco Klaassen, Natacha Retailleau, Terrence J. Sejnowski, August B. Smit, Jean-Baptiste Sibarita, Thomas M. Bartol, David Perrais, Vassiliki Nikoletopoulou, Daniel Choquet, Eric Hosy
Summary: Long-term depression (LTD) of synaptic strength is associated with circuit remodeling, memory encoding, and erasure. P2XR- and NMDAR-dependent LTD are linked to distinct molecular modifications that lead to specific changes in synapse function.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Magdalena Pereyra, Ana Belen de Landeta, Juliana Fatima Dalto, Cynthia Katche, Jorge H. Medina
Summary: The study shows that the activity of mTORC1 signaling pathway is crucial for the normal expression of aversive and non-aversive long-term memories during memory retrieval. Specifically, the de novo synthesis of GluA1 and GluA2 AMPAR subunits plays an important role in memory retrieval, with mTORC1 potentially regulating AMPAR trafficking during this process.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Environmental Sciences
Jing Song, Wenjing Li, Chunman Yuan, Ting Gao, Xiaoting Lu, Linping Wang, Qiao Niu
Summary: This study aims to explore a potential biomarker and mechanism for cognitive dysfunction following aluminum exposure. It was found that occupational aluminum exposure elevated miR-134-3p expression in the plasma of workers accompanied by cognitive impairment. Further experiments validated the involvement of miR-134-3p in aluminum neurotoxicity by targeting the zDHHC3-AMPARs axis. This finding may contribute to the development of potential biomarkers or therapeutic targets for cognitive dysfunction.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Immunology
Ying Li, Muhuo Ji, Jianjun Yang
Summary: Sepsis is a life-threatening condition that can lead to long-term cognitive impairment after hospital discharge. Mechanisms such as blood-brain barrier disruption and neuroinflammation have been proposed for this impairment. Further studies are needed to develop preventive and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychology, Clinical
Patricia S. Andrews, Jennifer Thompson, Rameela Raman, Chelsea Rick, Amy Kiehl, Pratik Pandharipande, James C. Jackson, Warren D. Taylor, E. W. Ely, Jo E. Wilson
Summary: This study found that patients with a history of depression before admission to the intensive care unit (ICU) exhibit more severe depressive symptoms in the year following hospitalization. However, this history of depression is not associated with cognitive performance.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Chemistry, Multidisciplinary
Wu Yang, Lin Ma, Dong-Mei Hai, Ning Liu, Jia-Mei Yang, Xiao-Bing Lan, Juan Du, Li-Shan Yang, Tao Sun, Jian Qiang Yu
Summary: This study established a model of aggressive behavior based on the clinical use of perampanel and found that long-term use of perampanel increased aggressive behavior in mice. Proteomic analysis revealed significant alterations in 93 proteins in the hippocampus of perampanel-treated mice, primarily related to synaptic function and the Ras signaling pathway. Validation results by western blot showed up-regulation of glutamate receptor 1 and phosphorylation of mitogen-activated protein kinase (ERK1/2), as well as down-regulation of synaptophysin and postsynaptic density 95 in perampanel-treated mice.
Article
Biotechnology & Applied Microbiology
Zhou-Liang Xu, GanLu Chen, XiangFei Liu, DaoFen Xie, Jie Zhang, YongGan Ying
Summary: The study found that ginsenosides can ameliorate memory impairment in rats caused by propofol anesthesia by increasing the expression levels of NGF and BDNF. Therefore, ginsenosides have the potential to serve as a novel therapeutic agent for postoperative cognitive dysfunction caused by propofol anesthesia.
Review
Health Care Sciences & Services
Gaia Sampogna, Matteo Di Vincenzo, Vincenzo Giallonardo, Francesco Perris, Antonio Volpicelli, Valeria Del Vecchio, Mario Luciano, Andrea Fiorillo
Summary: The COVID-19 pandemic has caused significant disruptions and psychological symptoms among the general population. This study aims to describe the psychiatric symptoms associated with long-COVID syndrome and evaluate the methodologies used in previous studies. The most common psychiatric symptoms of long-COVID syndrome include fatigue, cognitive impairment, depression, and anxiety.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Janette L. Vardy, Gregory R. Pond, Lucette A. Cysique, Thomas M. Gates, Jim Lagopoulos, Corrinne Renton, Louise M. Waite, Ian F. Tannock, Haryana M. Dhillon
Summary: There was no difference in cognitive capacity and function between CRC survivors and controls 6-12 years after diagnosis. Differences in neuroimaging require confirmation in a larger sample.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Medicine, General & Internal
Juan Chen, Zhigao Xiang, Zhuo Zhang, Yan Yang, Kai Shu, Ting Lei
Summary: Acromegaly is characterized by overproduction of growth hormone and accompanying insulin-like growth factor-1, leading to somatic burden and psychosocial changes. Studies have shown that patients with acromegaly often experience cognitive impairment and neuropsychological issues. This review outlines the impact of disease progression, treatment modalities, and comorbidities on cognitive function and the mechanisms of cognitive impairment in acromegaly patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Neurosciences
Karen Bohmwald, Catalina A. Andrade, Nicolas M. S. Galvez, Valentina P. Mora, Jose T. Munoz, Alexis M. Kalergis
Summary: This article discusses the increasing frequency of encephalitis, with infectious or autoimmune diseases being the most common causes. It highlights the clinical symptoms and impact of viral encephalitis on brain function, focusing on the neurocognitive sequelae that can persist even after the virus is cleared.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Felipe Figueredo Savi, Alexandre de Oliveira, Gabriela Ferreira de Medeiros, Fernando Augusto Bozza, Monique Michels, Tarek Sharshar, Felipe Dal-Pizzol, Cristiane Ritter
Summary: This review explored behavioral tools and tests used to evaluate cognitive dysfunction in different animal models of sepsis. Both CLP and LPS models were effective in inducing short-and long-term behavioral impairment.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Geriatrics & Gerontology
Hui Chen, Tianjing Zhou, Jie Guo, John S. Ji, Liyan Huang, Weili Xu, Guangmin Zuo, Xiaozhen Lv, Yan Zheng, Albert Hofman, Yuan Ma, Changzheng Yuan
Summary: This prospective study found a significant association between long-term body weight variability (BWV) and the risk of dementia, independent of mean body weight and body weight change.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Rick Yiu Cho Kwan, Chi Wai Kwan, Patrick Pui Kin Kor, Iris Chi
Summary: Hearing and vision impairments are associated with cognitive decline, and the use of audio-visual aids can mediate these relationships. In long-term care facilities, residents with hearing and vision impairments have a higher risk of cognitive decline. The use of hearing aids positively mediates the effect of hearing impairment on cognitive decline, while the use of visual aids negatively mediates the effects of visual impairment on cognitive decline.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)