Article
Behavioral Sciences
Xue-Fei Hou, Ya-Bo Zhao, Yue-Xiong Yang, Jing Zhu, Li-Su Zhu, Lin Xu, Qi-Xin Zhou
Summary: In this study, a simple and effective experimental model was designed to investigate the generalization memory of morphine reward. By replacing the conditioning CPP box, it was found that mice still showed a clear preference for generalized information. The establishment of this study provides a new tool for studying generalization memory in substance use disorders.
BRAIN AND BEHAVIOR
(2023)
Article
Behavioral Sciences
Nicole C. Reyna, John T. Madden, Kenneth J. Thiel, Nathan S. Pentkowski
Summary: This study used a conditioned place preference model to examine the influence of methamphetamine and social rewards in adolescent male rats. The results showed that rats receiving methamphetamine with a social partner demonstrated a significantly greater preference shift compared to other groups, highlighting the importance of social context in influencing drug reward during adolescence.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Neurosciences
Zahra Rezaei, Hojjatallah Alaei, Parham Reisi
Summary: This study examined the role of the basolateral amygdala (BLA) in morphine addiction. The results showed that electrical stimulation of the BLA induced conditioned place preference (CPP), while inactivation of the BLA inhibited morphine-induced CPP.
NEUROSCIENCE LETTERS
(2022)
Article
Behavioral Sciences
Skyler M. Sklenarik, Christopher N. Burrows, Robert S. Astur
Summary: This study examines the establishment of conditioned place preference (CPP) using virtual alcohol cues and finds that participants with alcohol use spend significantly more time in the conditioned room compared to participants without alcohol use during the test session. However, participants with alcohol use do not subjectively report a preference for the conditioned room.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Clinical Neurology
L. Rocco, A. Pisera-Fuster, M. P. Faillace, R. Bernabeu
Summary: This study used a modified conditioned place preference paradigm to assess zebrafish's preference for nicotine and its association with environmental cues. The results showed that zebrafish's seeking behavior was closely related to the shades of compartment colors, and they spent more time in the environment associated with nicotine.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Jakkrit Nukitram, Dania Cheaha, Ekkasit Kumarnsit
Summary: The study found that local field potential oscillations in the basolateral amygdala were sensitive to METH conditioned place preference (CPP), with the METH group significantly increasing time spent in the METH-paired compartment during post-conditioning with METH cues. Significant suppressions of theta and alpha powers were observed in neural signals, indicating the neural mechanisms of METH CPP.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Angela E. Gonzalez, Emily T. Jorgensen, Jonathan D. Ramos, John H. Harkness, Jake A. Aadland, Travis E. Brown, Barbara A. Sorg
Summary: Parvalbumin (PV) positive cells in the medial prefrontal cortex (mPFC) regulate the activity of pyramidal neurons and are surrounded by a structure called the perineuronal net (PNN). The removal of PNNs with chondroitinase-ABC (Ch-ABC) prevents the consolidation and reconsolidation of cocaine-associated conditioned place preference (CPP) memories. This study explores the effects of CPP memory retrieval during cocaine-primed reinstatement on PV neurons and PNNs, and the impact of PNN removal on PV intensity and function. The findings suggest that PNN removal partially reduces reinstatement and that cocaine-induced reinstatement leads to changes in PV intensity and excitability, potentially affecting the maintenance of cocaine memory during reconsolidation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kristof Laszlo, David Voros, Orsolya Kiss, Bettina Reka Laszlo, Tamas Ollmann, Laszlo Peczely, Kitti Mintal, Attila Toth, Anita Kovacs, Olga Zagoracz, Erika Kertes, Veronika Kallai, Beata Berta, Zoltan Karadi, Laszlo Lenard
Summary: This study found that oxytocin injected into the central nucleus of the amygdala has positive reinforcing effects in a rat model of autism induced by valproate. The effects are specific to oxytocin receptors and are blocked by a dopamine D2 receptor antagonist. The findings suggest a potential role for oxytocin and the dopaminergic system in the treatment of autism.
Article
Neurosciences
Darrell Eacret, Crystal Lemchi, Jasmine I. Caulfield, Sonia A. Cavigelli, Sigrid C. Veasey, Julie A. Blendy
Summary: This study investigates the influence of chronic short sleep on opioid reward using a mouse model. The results show that recovery sleep after chronic sleep disruption lessens voluntary opioid intake, but does not affect conditioned reward associated with morphine.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Fahad S. Alshehri, Badrah S. Alghamdi, Alqassem Y. Hakami, Abdullah A. Alshehri, Yusuf S. Althobaiti
Summary: The study found that melatonin can attenuate morphine-seeking behavior and reduce morphine-induced place preference.
BRAIN AND BEHAVIOR
(2021)
Article
Pharmacology & Pharmacy
Gabrielle M. Henriques, Alexia Anjos-Santos, Isa R. S. Rodrigues, Victor Nascimento-Rocha, Henrique S. Reis, Matheus Libarino-Santos, Thaisa Barros-Santos, Thais S. Yokoyama, Natalia B. Bertagna, Cristiane A. Favoretto, Celia R. G. Moraes, Fabio C. Cruz, Paulo C. R. Barbosa, Eduardo A. Marinho, Alexandre J. Oliveira-Lima, Lais F. Berro
Summary: Ibogaine may have therapeutic properties for the treatment of alcohol use disorder without having rewarding effects per se. The study results show that ibogaine can block the reinstatement of ethanol-induced CPP, suggesting its potential as a treatment option for alcohol use disorder.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Cesar Huerta, Raul G. Paredes, Teresa Morales, Mario Daniel Caba-Flores, Enrique Meza, Mario Caba
Summary: This study aims to establish whether rabbits can be conditioned using CPP protocol by conducting experiments with caloric restriction. It demonstrates for the first time that rabbits can be conditioned using CPP paradigm through food-induced place preference, opening up new opportunities to study positive affective states in a species with important behavioral and physiological differences from rodents.
Article
Behavioral Sciences
Zhi-yuan Wang, Liang-kun Guo, Xiao Han, Rui Song, Guo-ming Dong, Chun-ming Ma, Ning Wu, Jin Li
Summary: The study investigated the effects of naltrexone on the properties of incentive salience and reward-related memory in methamphetamine addiction using mouse models. Naltrexone was found to reduce methamphetamine-induced hyper locomotion and suppress the development of locomotor sensitization, suggesting its therapeutic potential in treating methamphetamine addiction. These findings demonstrate that naltrexone could intervene in the incentive salience and reward-related memory properties, contributing to its therapeutic effects on methamphetamine addicts in clinical studies.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Ellen R. Cullity, Alexandre A. Guerin, Christina J. Perry, Jee Hyun Kim
Summary: Adolescents may be more sensitive to the rewarding effects of methamphetamine, while females may be less likely to form an aversion compared to males. These results are in line with sex-specific findings in human research.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Jing Wang, Min Liang, Qing Shang, Hongyan Qian, Ran An, Hua Liu, Gaojie Shao, Tao Li, Xinshe Liu
Summary: Psilocin has regulatory effects on METH-induced alterations of behavior in mice through D2R-mediated signal regulation of ERK phosphorylation.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)