期刊
BEHAVIOURAL BRAIN RESEARCH
卷 205, 期 2, 页码 499-504出版社
ELSEVIER
DOI: 10.1016/j.bbr.2009.08.006
关键词
Chlorpyrifos; Mice; Morris maze testing; Neural stem cell therapy; Neurobehavioral teratogenicity; Nicotine therapy; Prenatal exposure
资金
- The United States-Israel Binational Science Foundation [BSF2005003, NIH ES014258]
Identifying the mechanisms underlying the adverse effects of developmental neurotoxicants enables the design of therapies that can potentially reverse neurobehavioral deficits in adulthood. We administered chlorpyrifos (CPF), a model organophosphate pesticide to pregnant mice and identified visuospatial deficits in adult offspring using performance in the Morris maze. We then evaluated two strategies to reverse the effects, nicotine administration and transplantation of neural stein cells. Daily administration of nicotine prior to behavioral testing did not alter maze performance by itself, but completely reversed the deficits evoked by prenatal CPF exposure. Similarly. control animals grafted with neural stem cells in adolescence did not show any alterations in behavioral performance a adults, but the grafts completely reversed the effects of prenatal CPF treatment This study thus provides a model for the development and application of both pharmacologic and cell-based therapies to offset the effects of neurobehavioral teratogens (C) 2009 Elsevier B.V. All rights reserved.
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