Article
Cell Biology
Shuai Zhang, Juanjuan Duan, Yu Du, Jinlu Xie, Haijing Zhang, Changyu Li, Wensheng Zhang
Summary: This study explored the profiles of long non-coding RNAs (lncRNAs) in the liver genomes of SAMP8 and SAMR1 mouse models, revealing that certain lncRNAs play a role in liver aging and could serve as potential targets for molecular-based diagnosis and therapy of age-related liver diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Wenlong Hao, Sulan Luo, Lamei Hao, Feifei Zhang
Summary: Procyanidins from lotus seedpods (LSPCs) have protective effects on traumatic brain injury by reducing inflammation and oxidative stress. LSPCs attenuate microglia activation, brain edema, and the release of inflammatory factors by inhibiting the activation of the TLR4/NF-KB pathway.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Jianmei Wang, Tao Yu, Liuqing Sheng, Hui Zhang, Fei Chen, Jie Zhu, Mingxing Ding
Summary: The study demonstrated that lotus seedpod proanthocyanidins (LSPCs) effectively protected against light exposure-induced retinal damage through antioxidative stress, anti-apoptosis, and neuroprotective effects. The findings highlighted the potential therapeutic benefits of LSPCs in preventing retinal degeneration caused by excessive exposure to visible white light.
MEDICAL SCIENCE MONITOR
(2021)
Article
Nutrition & Dietetics
Li-Ya Lee, Wayne Chou, Wan-Ping Chen, Ming-Fu Wang, Ying-Ju Chen, Chin-Chu Chen, Kwong-Chung Tung
Summary: The study demonstrated that Hericium erinaceus mycelium enriched with erinacine A improved learning and memory in mice, reduced levels of aging-related biomarkers, such as iNOS, TBARS, and 8-OHdG, in a dose-dependent manner. This suggests that Hericium erinaceus mycelium may have potential neuroprotective effects in delaying brain aging.
Review
Cell Biology
Nanshuo Cai, Yifan Wu, Yan Huang
Summary: With the global increase in the elderly population, understanding the mechanisms of aging and aging-related disorders has become crucial. Mice have emerged as prevalent animal models for aging studies due to their genetic similarity, physiological structure, short lifespan, and ease of reproduction. This review discusses common and emerging mouse models used in the study of accelerated aging and chronic diseases, aiming to provide a reference for future research in fundamental and translational studies.
Article
Cell Biology
Chetan Ahire, Adam Nyul-Toth, Jordan DelFavero, Rafal Gulej, Janet A. Faakye, Stefano Tarantini, Tamas Kiss, Anna Kuan-Celarier, Priya Balasubramanian, Anna Ungvari, Amber Tarantini, Raghavendra Nagaraja, Feng Yan, Qinggong Tang, Peter Mukli, Tamas Csipo, Andriy Yabluchanskiy, Judith Campisi, Zoltan Ungvari, Anna Csiszar
Summary: Chemotherapy-induced cognitive impairment (chemobrain) is a common side effect in cancer survivors treated with paclitaxel. This study investigates the hypothesis that paclitaxel induces endothelial senescence, which impairs microvascular function and contributes to cognitive decline.
Review
Oncology
Jorge Morales-Valencia, Gregory David
Summary: Senescent cells play a crucial role in cancer progression by altering cancer cell properties and promoting tumor growth through the generation of a supportive microenvironment. Recent studies indicate that senescent cells have the capacity to resume proliferation and drive cancer relapse, highlighting the potential use of senolytics and SASP modulators to prevent tumor resurgence. Understanding the mechanisms of senescence and the impact of SASP may lead to the development of targeted therapeutic strategies to exploit vulnerabilities associated with this cellular state.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yuli Hou, Qiao Song, Yaqi Wang, Jing Liu, Yuting Cui, Xiaomin Zhang, Jingjing Zhang, Jingxuan Fu, Min Cao, Chi Zhang, Congcong Liu, Xiaoling Wang, Huanli Duan, Peichang Wang
Summary: The study found that KLF14 plays a suppressive role in cellular senescence during aging. Lack of KLF14 leads to cellular senescence and aging-related pathologies, while overexpression of KLF14 can attenuate cellular senescence. Additionally, activating KLF14 to upregulate POLD1 expression can delay cellular senescence and aging-related pathologies.
Review
Oncology
Shuo Wang, Anna Prizment, Bharat Thyagarajan, Anne Blaes
Summary: Many cancer treatments may lead to accelerated aging in cancer survivors, impacting long-term health and quality of life. Understanding the biological mechanisms and methods for estimating biological age in cancer survivors is important for predicting treatment-related comorbidities and personalizing cancer therapies. Novel strategies to reduce treatment-induced accelerated aging and improve quality of life in cancer survivors may result from a deeper understanding of these mechanisms.
Article
Biochemistry & Molecular Biology
Renata R. Bruno, Fernanda C. Rosa, Paula C. Nahas, Flavia M. S. de Branco, Erick P. de Oliveira
Summary: Aging is associated with decreased muscle strength and increased reactive oxygen species. This cross-sectional study found that serum levels of alpha-carotene were positively associated with muscle strength in older adults, while other antioxidants were not. This suggests that alpha-carotene may have a beneficial effect on muscle strength in aging individuals.
Review
Biochemistry & Molecular Biology
Barbara Jacczak, Blazej Rubis, Ewa Toton
Summary: The stability of telomeres is crucial for cell function, and research on telomere biology and telomerase activity has been of great interest in various medical and scientific fields. Maintaining optimal telomere length and telomerase activity is an important step in anti-aging strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Qianlan Xu, Cezary Rydz, Viet Anh Nguyen Huu, Lorena Rocha, Claudia Palomino La Torre, Irene Lee, William Cho, Mary Jabari, John Donello, David C. Lyon, Robert T. Brooke, Steve Horvath, Robert N. Weinreb, Won-Kyu Ju, Andrzej Foik, Dorota Skowronska-Krawczyk
Summary: Aging increases susceptibility to stress response in the retina, which is primed at the chromatin level. Ocular hypertension activates a stress response similar to natural aging, involving inflammation and senescence. Repeated pressure elevation accelerates aging features in the retina and involves chromatin modifications.
Article
Endocrinology & Metabolism
Jiatong Liu, Xi Lin, Andrew McDavid, Yutiancheng Yang, Hengwei Zhang, Brendan F. F. Boyce, Lianping Xing
Summary: Cellular senescence plays a crucial role in age-related diseases, such as musculoskeletal disorders, but the interaction between senescent cells (SCs) and inflammatory cells (Inf-Cs) during fracture repair is not well understood. This study analyzed single cell RNA sequencing data of aged mouse fracture callus stromal cells and identified three cell subclusters associated with inflammation and senescence. The researchers found that Inf-SCs and SCs had similar gene expression profiles and upregulated pathways related to DNA damage/oxidation-reduction and cellular senescence, while Inf-Cs expressed different gene signatures mainly related to inflammation. They also demonstrated that SCs and Inf-SCs could potentially affect Inf-Cs as target cells through the production of active ligands. Furthermore, cell culture experiments showed that SC-conditioned medium promoted inflammatory gene expression and reduced osteoblast differentiation capacity in callus-derived mesenchymal progenitor cells.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Wei Zhang, Siyu Xia, Wei Xiao, Yali Song, Li Tang, Min Cao, Jing Yang, Shuang Wang, Zhijie Li, Chengchao Xu, Jianqiao Liu, Shanchao Zhao, Chuanbin Yang, Jigang Wang
Summary: This study focuses on the reproductive issues of advanced paternal age and analyzes the molecular and cellular changes associated with aging in the testes of mice. The study discovers various aging-related biological processes and identifies an increased subtype of aging-specific macrophages that contribute to a proinflammatory environment during testicular aging.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Nutrition & Dietetics
Ming-Yu Chou, Yue-Ching Wong, Shih-Yi Wang, Ching-Hsin Chi, Teng-Hsu Wang, Mao-Jung Huang, Ping-Hsiu Huang, Po-Hsien Li, Ming-Fu Wang
Summary: This study evaluated the benefits of feeding Huang qi and its complexes to aging mice and found that it enhanced locomotor performance and had anti-aging effects, with positive effects on health, learning, and memory. These findings support the development and value-added of astragalus-related products in the functional food market.
FRONTIERS IN NUTRITION
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)