期刊
BEHAVIOURAL BRAIN RESEARCH
卷 188, 期 2, 页码 310-315出版社
ELSEVIER
DOI: 10.1016/j.bbr.2007.11.015
关键词
spatial information processing; CA1; CA3; episodic memory; temporal context
资金
- NIMH NIH HHS [R01 MH065314-04, R01 MH 065314, R01 MH065314] Funding Source: Medline
It has been suggested that the hippocampus mediates episodic memory processing involving snapshot memory and temporal sequence learning. To test this theory. rats learned trial-unique sequences of spatial locations along a runway box and were tested on recall by removing one of the locations in the sequence and making the rat choose the correct location to be rewarded. Once animals were able to reliably perform this episodic memory task, they received lesions to either CA3 or CA1. Animals with lesions to either CA3 or CA1 had difficulty with episodic memory processing, although CA1 lesioned animals had a much greater deficit. However, when animals were trained on a non-episodic version of the same task, hippocampal lesions had no effect. These results suggest that CA3 and CA1 both contribute to episodic memory processing since lesions to CA3 or CA1 result in an inability to process spatial information episodically, whereas they have no effect on non-episodic information processing. (C) 2007 Elsevier B.V. All rights reserved.
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