期刊
BEHAVIOURAL BRAIN RESEARCH
卷 188, 期 2, 页码 391-397出版社
ELSEVIER
DOI: 10.1016/j.bbr.2007.11.026
关键词
doublecortin; memory; neurogenesis; BrdU; Ki67
资金
- NIMH NIH HHS [R01 MH067156, MH 0671560, R01 MH067156-05] Funding Source: Medline
In addition to its role in neuronal migration during embryonic development, doublecortin (DCX) plays a role in hippocampal neurogenesis across the lifespan. Hippocampal neurons exhibit a high degree of synaptic plasticity while they are in the DCX phase. While previous studies have reported that behavioral training on hippocampus-dependent tasks can enhance neuron survival, little was known about the stage of development of those neurons and, particularly, whether a large pool of the surviving new neurons remains in the DCX phase for a prolonged period after training. Here we report that spatial navigation training increases the pool of neurons that are in the DCX phase 4 weeks after training ended. Thus, the stock of DCX-expressing neurons in the hippocampus is affected by whether a hippocampus-dependent task has been encountered during the preceding few weeks. (c) 2007 Elsevier B.V. All rights reserved.
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