Article
Neurosciences
Adam Gordon-Fennell, Garret D. Stuber
Summary: Studies have revealed generalizable findings across molecularly defined cell types in areas of the basal forebrain and anterior hypothalamus. Optogenetic stimulation of GABAergic neurons in these brain regions drives reward, while optogenetic stimulation of glutamatergic neurons in these regions drives aversion.
Article
Neurosciences
Cristina Banuelos, Joshua R. Kittleson, Katherine H. Lanasa, Christina S. Galiano, Stephanie M. Roth, Evelyn J. Perez, Jeffrey M. Long, Mary T. Roberts, Sania Fong, Peter R. Rapp
Summary: This study found that the GABAergic component of the primate basal forebrain is more vulnerable to aging, leading to a potential loss of inhibitory drive to cortical circuitry. Adaptive reorganization of the GABAergic circuitry may contribute to successful neurocognitive outcomes in aging.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biology
Didier De Saint Jan
Summary: This study investigated the role of basal forebrain (BF) inputs in modulating activity of different subtypes of periglomerular (PG) interneurons in the olfactory bulb (OB). The results showed that GABAergic BF inputs effectively inhibited PG cell firing, while cholinergic inputs excited a previously overlooked PG cell subtype. These findings highlight the importance of external inputs in synaptic inhibition in the OB.
Article
Neurosciences
Ping Cai, Wei-Kun Su, Jin-Sheng Zhang, Pei-Chang Liu, Feng Liu, Ren-Fu Liu, Zhang-Shu Li, Zhong-Hua Zhu, Wen-Hao Xiao, Yong-Huai Hu, Hong-Da Cai, Xiao-Dan Wu, Liang-Cheng Zhang, Changxi Yu, Li Chen
Summary: Recent evidence suggests a potential overlap between general anesthesia and sleep-wake behavior. In this study, using fiber photometry, it was observed that the activity of GABAergic neurons in the basal forebrain (BF) was inhibited during isoflurane anesthesia, but gradually restored during emergence. Activation of these neurons reduced sensitivity to isoflurane, delayed induction, and accelerated emergence from anesthesia. Photostimulation of GABAergic terminals in the thalamic reticular nucleus (TRN) also promoted cortical activation and behavioral emergence from anesthesia.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Yanfeng Wang, Yanping Song, Li Tong, Lu Wang, Jiangbei Cao, Gang Qin, Xingyang Liu, Weidong Mi, E. Wang, Yongxin Guo
Summary: The GABA system in the central nervous system plays a crucial role in regulating anesthetic consciousness. The medial hypothalamus, including the ventromedial hypothalamus and dorsomedial hypothalamus, is involved in sleep and circadian rhythm. However, the specific role of GABAergic neurons in the medial hypothalamus in anesthesia is still unknown.
Article
Geriatrics & Gerontology
Eunyoung Bang, Angelika Tobery, Karienn S. Montgomery, Annette S. Fincher, David J. Earnest, David A. Murchison, William H. Griffith
Summary: The study investigated the mechanism of action of amitriptyline in aged mice and found that low concentrations of amitriptyline can reduce the frequency of inhibitory postsynaptic currents by modulating neurotransmitter release, with this effect not diminishing in aged mice.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Ping Zhou, Penglai Liu, Ying Zhang, Dejuan Wang, Anan Li
Summary: Cholinergic and GABAergic neurons in the basal forebrain show differences in their response dynamics and roles during olfactory learning. Cholinergic neurons reflect attention to positive reinforcement and may regulate odor discrimination via top-down inputs. Inactivation of cholinergic neurons impairs odor discrimination.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Aaron Kucinski, Cassandra Avila, Martin Sarter
Summary: The study indicates that there are differences in cognitive-behavioral styles between sign tracking and goal tracking, with different projection systems influencing attentional performance. Goal tracking relies on basal forebrain activity and is associated with model-based performance.
Article
Multidisciplinary Sciences
Panna Hegedus, Katalin Sviatko, Balint Kiraly, Sergio Martinez-Bellver, Balazs Hangya
Summary: Basal forebrain cholinergic neurons have an important role in associative learning and processing stimuli that predict future outcomes. This study used calcium imaging and spiking recordings to investigate the impact of outcome probabilities on these neurons in mice. The results showed that the cholinergic neurons responded more strongly to sensory cues that were often paired with reward, and reward delivery activated the neurons, with surprising rewards generating a stronger response. The findings suggest that the cholinergic neurons differentially weigh predictions of positive and negative reinforcement, reflecting the relative salience of appetitive and aversive outcomes.
Article
Biochemistry & Molecular Biology
Alma Hrnjadovic, James Friedmann, Sandra Barhebreus, Patricia J. Allen, Bernat Kocsis
Summary: The study aimed to investigate the role of 5-HT7 receptors in the reversal learning component of ASST and found that 5-HT7 receptor antagonist could reverse the impaired performance induced by NMDA receptor blockade, particularly affecting the reversal phases of ASST.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Neurosciences
Christoph Strauch, Chin -An Wang, Wolfgang Einhaeuser, Stefan van der Stigchel, Marnix Naber
Summary: The process of pupillary constriction and dilation can provide an accessible, affordable, and non-invasive measure of brain activity. A new taxonomy is proposed to understand the factors affecting pupil size and their neural underpinnings. Pupil size serves as an integrated measure of different attentional states.
TRENDS IN NEUROSCIENCES
(2022)
Article
Neurosciences
Megan K. Gautier, Christy M. Kelley, Sang Han Lee, Melissa J. Alldred, John Mcdaid, Elliott J. Mufson, Grace E. Stutzmann, Stephen D. Ginsberg
Summary: Down syndrome (DS), a genetic disorder, affects brain development and cognitive abilities. Maternal choline supplementation shows potential for protecting vulnerable neurons and improving cognitive function.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Chiara Orciani, Helene Hall, Rowan Pentz, Morgan K. Foret, Sonia Do Carmo, Augusto Claudio Cuello
Summary: The destruction of cholinergic nuclei in the basal forebrain can impair cognition and reduce cortical neuron markers, while also affecting brain-derived neurotrophic factor (BDNF) levels, but not nerve growth factor (NGF) levels.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Neurosciences
Jay-Shake Li, Shan-Sung Yang, Joseph P. Huston, Owen Y. Chao, Yi-Mei Yang, Claudia Mattern
Summary: Studies suggest that intranasal dopamine could potentially improve inhibitory control deficits in ADHD animal models, but caution is advised in determining the dosage due to potential negative effects, as seen in control groups.
PSYCHOPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Daniela Cernotova, Ales Stuchlik, Jan Svoboda
Summary: The study aimed to investigate the roles of the ventral hippocampus and medial prefrontal cortex in a place avoidance task on a rotating arena using two spatial flexibility task variants - reversal learning and set-shifting. The results showed significantly disrupted performance in reversal learning in the ventral hippocampus-inactivated rats, while the medial prefrontal cortex does not seem to be taxed in these flexibility tasks on a rotating arena.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Neurosciences
David S. Tait, Janice M. Phillips, Andrew D. Blackwell, Verity J. Brown
Review
Psychology, Clinical
Shri Cameron, Verity J. Brown, Barbara Dritschel, Kevin Power, Malcolm Cook
PSYCHOLOGY AND PSYCHOTHERAPY-THEORY RESEARCH AND PRACTICE
(2017)
Review
Behavioral Sciences
David S. Tait, Eric M. Bowman, Lorenz S. Neuwirth, Verity J. Brown
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2018)
Article
Neurosciences
Sandeep S. Dhawan, Shuang Xia, David S. Tait, Christoffer Bundgaard, Ellen Bowman, Verity J. Brown
PSYCHOPHARMACOLOGY
(2018)
Article
Behavioral Sciences
Birgit Szabo, Daniel W. A. Noble, Richard W. Byrne, David S. Tait, Martin J. Whiting
Editorial Material
Behavioral Sciences
Martin O'Neill, Verity Brown
BEHAVIOURAL BRAIN RESEARCH
(2018)
Article
Behavioral Sciences
Jenny M. Daggett, Verity J. Brown, Caroline H. Brennan
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Behavioral Sciences
Sandeep S. Dhawan, David S. Tait, Verity J. Brown
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Behavioral Sciences
Jiachao Wang, David S. Tait, Verity J. Brown, Eric M. Bowman
BEHAVIOURAL BRAIN RESEARCH
(2019)
Review
Pharmacology & Pharmacy
David S. Tait, E. Alexander Chase, Verity J. Brown
CURRENT PHARMACEUTICAL DESIGN
(2014)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)