Review
Cell Biology
Amrita Kulkarni, Kumari Preeti, Kamatham Pushpa Tryphena, Saurabh Srivastava, Shashi Bala Singh, Dharmendra Kumar Khatri
Summary: Protein dyshomeostasis plays a key role in age-related neurodegenerative disorders, such as Parkinson's disease, characterized by the deposition of Lewy bodies composed of alpha-synuclein protein aggregates. The proper functioning of proteostasis, including unfolded protein response, ubiquitin-proteasome system, and autophagy-lysosome pathway, is crucial for protein synthesis, folding, confirmation, and degradation. Mutational changes in the genes involved in these pathways, as well as epigenetic modifications and microRNA-mediated transcriptional changes, contribute to proteostasis dysregulation. Defective proteostasis leads to the deposition of proteins, which can serve as potential biomarkers for early diagnosis of Parkinson's disease. Targeting different aspects of proteostasis machinery holds promise for delaying the accumulation of pathological hallmarks.
AGEING RESEARCH REVIEWS
(2023)
Article
Mathematical & Computational Biology
Sandeep Sathyanandan Nair, Vignayanandam Ravindernath Muddapu, V. Srinivasa Chakravarthy
Summary: A multiscale computational model has been developed to replicate Parkinson's disease symptoms and demonstrate the effects of medication. This model reveals the relationship between dopaminergic axonal degeneration in the basal ganglia and various symptoms of Parkinson's disease, and can predict personalized medication dosage.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Anais Marie, Julien Leroy, Morgane Darricau, Serge Alfos, Veronique De Smedt-Peyrusse, Emmanuel Richard, Sylvie Vancassel, Clementine Bosch-Bouju
Summary: Vitamin A supplementation partially alleviates motor alterations and improves striatal function in a rat model of PD, suggesting a potential beneficial preventive approach for the disease.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Kathryn L. Todd, Janusz Lipski, Peter S. Freestone
Summary: This study identified a distinct population of dopamine neurons that project to the tail region of the striatum, separate from the classic nigrostriatal pathway. The tail striatum was found to have lower basal and evoked dopamine levels, as well as diverse dopamine release kinetics compared to the dorsolateral striatum. Stimulation of the subthalamic nucleus (STN) exclusively evoked dopamine release in the tail striatum, likely mediated by the SNL. These findings suggest the existence of a novel dopamine pathway to the tail striatum, largely independent of the classic nigrostriatal pathway, and highlight the STN as an important modulator of dopamine release in this pathway.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jiang-Peng Fan, Hui-Zhen Geng, Ya-Wei Ji, Tao Jia, Jennifer B. Treweek, An-An Li, Chun-Yi Zhou, Viviana Gradinaru, Cheng Xiao
Summary: Key components in the nigrostriatal DA system exhibit distinct aging patterns and may contribute to age-related alterations in locomotion and coordination.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Neurosciences
Kamil Pradel, Gniewosz Drwiega, Tomasz Blasiak
Summary: Dopaminergic neurons in the midbrain are controlled by various brain structures, with the superior colliculus providing sensory input to the contralateral rostromedial tegmental nucleus (RMTg), an inhibitory input to dopaminergic neurons. Activation of the contralateral superior colliculus excites RMTg neurons, while stimulation of the ipsilateral side leads to both excitatory and inhibitory responses, suggesting a role of this pathway in orienting and motivation-driven locomotion of animals.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Adelie Salin, Virginie Lardeux, Marcello Solinas, Pauline Belujon
Summary: This study found that dopamine activity in the VTA is decreased in rats with extended access to cocaine, while there were no changes in dopamine activity in the SNc. These changes in VTA dopamine activity may contribute to the negative emotional state and the incubation of drug seeking during abstinence.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Lixue Lin, Yuye Lan, He Zhu, Lingling Yu, Shuang Wu, Wangyixuan Wan, Yang Shu, Hongchun Xiang, Tengfei Hou, Hong Zhang, Yan Ma, Wen Su, Man Li
Summary: In TS mice, chemogenetic inhibition of D1R- or D2R-containing neurons in the SNpc and dSTR alleviated stereotyped behavior and motor dysfunctions. On the other hand, activation of D1R-containing neurons in the dSTR may worsen stereotyped behavior in TS. This provides new targets for treatment and further studies on the pathogenesis of TS.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Cui Liu, Nan-Wei Kang, Ying Wang, Yan Xue, Xin-Yi Chen, Lei Chen
Summary: The present study investigated the effects of apelin on the spontaneous firing activity of nigral dopaminergic neurons and found that it may serve as a neuroprotective factor in Parkinson's disease.
Article
Neurosciences
Cui Liu, Nan-Wei Kang, Ying Wang, Yan Xue, Xin-Yi Chen, Lei Chen
Summary: The neuropeptide apelin modulates the firing activity of nigral dopaminergic neurons and may serve as a neuroprotective factor in Parkinson's disease.
Article
Multidisciplinary Sciences
Xiaoyu Liu, Hao Zhang, Chuanfen Li, Zhibin Chen, Qian Gao, Muxuan Han, Feng Zhao, Dan Chen, Qiuyue Chen, Minghui Hu, Zifa Li, Sheng Wei, Xiwen Geng
Summary: This study aimed to determine the optimal dose and administration duration of curcumin in alleviating the movement symptoms of Parkinson's disease. The results showed that a 160 mg/kg/d treatment for 2 weeks was the most effective in improving behavioral disorders, while the 40/80 mg/kg/d treatments had limited effectiveness. Comparing the effects of 1-week and 2-week interventions, the 2-week treatment showed better alleviation of symptoms.
Article
Neurosciences
Mario Antonazzo, Sonia Maria Gomez-Urquijo, Luisa Ugedo, Teresa Morera-Herreras
Summary: The basal ganglia (BG) play a role in movement control, cognitive, and motivational functions, with the CB1 cannabinoid receptor and dopamine playing key roles in BG circuits. Research shows that loss of dopamine alters information processing in the circuits, potentially leading to non-motor symptoms in Parkinson's disease patients.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Abubakar Atiq, Hyeon Jin Lee, Amjad Khan, Min Hwa Kang, Inayat Ur Rehman, Riaz Ahmad, Muhammad Tahir, Jawad Ali, Kyonghwan Choe, Jun Sung Park, Myeong Ok Kim
Summary: Trolox is a potent antioxidant that has been used to investigate the effects of oxidative stress in biological systems. It has demonstrated neuroprotective effects against ischemia and IL-1 beta-mediated neurodegeneration. This study explored the potential protective mechanisms of Trolox against a Parkinson's disease mouse model induced by MPTP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Ernest W. W. Wang, Gregory L. L. Brown, Mechelle M. M. Lewis, Leslie C. C. Jellen, Cunfeng Pu, Melinda L. L. Johnson, Hairong Chen, Lan Kong, Guangwei Du, Xuemei Huang
Summary: This retrospective study found that susceptibility MRI metrics in the substantia nigra pars compacta (SNc) are associated with glial density and tau burden, key neuropathologic features in parkinsonism. The results highlight the importance of MRI in assessing the pathological characteristics of SNc in Parkinson's disease.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Young Hee Sung, Young Noh, Eung Yeop Kim
Summary: Thin-section neuromelanin-sensitive MRI provides insights into the affected regions of the substantia nigra pars compacta in early-stage Parkinson's disease, with specific areas (nigrosome 1 and 2) showing significant spatial differences between patients and healthy subjects.
HUMAN BRAIN MAPPING
(2021)
Article
Oncology
Thiago Jacomasso, Hennrique Taborda Ribas, Marina Trombetta-Lima, Michelle Silberspitz Konig, Edvaldo Silva Trindade, Glaucia Regina Martinez, Mari Cleide Sogayar, Sheila Maria Brochado Winnischofer
Article
Behavioral Sciences
Joyce Mendes-Gomes, Simone Cristina Motta, Ricardo Passoni Bindi, Amanda Ribeiro de Oliveira, Farhad Ullah, Marcus Vinicius C. Baldo, Norberto Cysne Coimbra, Newton Sabino Canteras, D. Caroline Blanchard
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Bianca Busato, Elaine Cristina de Almeida Abreu, Carmen Lucia de Oliveira Petkowicz, Glaucia Regina Martinez, Guilhermina Rodrigues Noleto
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Materials Science, Biomaterials
Arthur Poester Cordeiro, Paulo Emilio Feuser, Pedro Graupen Figueiredo, Elizabeth Sousa da Cunha, Glaucia Regina Martinez, Ricardo Andrez Machado-de-Avila, Maria Eliane Merlin Rocha, Pedro Henrique Hermes de Araujo, Claudia Sayer
Summary: The study aimed to encapsulate sodium diethyldithiocarbamate (DETC) and 4-nitrochalcone (4NC) in beeswax nanoparticles (BNs) to evaluate the synergistic activity against melanoma cells. The results showed that DETC and 4NC loaded in BNs exhibited higher cytotoxicity towards B16F10 cells and the simultaneous encapsulation led to a synergistic effect on cell viability.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Ana Luiza Dorigan de Matos Furlanetto, Fernando Diego Kaziuk, Glaucia Regina Martinez, Lucelia Donatti, Maria Eliane Merlin Rocha, Andre Luis Wendt dos Santos, Eny Iochevet Segal Floh, Silvia Maria Suter Correia Cadena
Summary: This study evaluated the differences in antioxidant enzyme activities and mitochondrial functions during the proliferation of embryogenic cells of Araucaria angustifolia that are responsive (SE1) and non-responsive (SE6) to somatic embryo development. The results show significant differences in mitochondrial functions and antioxidant enzyme activities between SE1 and SE6 embryogenic cells, which may play a crucial role in the induction of in vitro maturation processes.
FREE RADICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
William N. Sanchez, Jose A. Pochapski, Leticia F. Jessen, Marek Ellenberger, Rainer K. Schwarting, Donita L. Robinson, Roberto Andreatini, Claudio Da Cunha
Summary: The study found that diazepam can mitigate the neurochemical and psychostimulant effects of cocaine, such as reducing dopamine signals, inhibiting the increase in 50-kHz calls, and decreasing cocaine-induced locomotion.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biology
Miguel Antonio Xavier de Lima, Marcus Vinicius C. Baldo, Fernando A. Oliveira, Newton Sabino Canteras
Summary: This study reveals the important role of the anterior cingulate area (ACA) in the acquisition and expression of contextual fear in mice.
Article
Neurosciences
Ricardo P. Bindi, Ricardo G. O. Maia, Francesca Pibiri, Marcus Vinicius C. Baldo, Steven L. Poulter, Colin Lever, Newton S. Canteras
Summary: In this study, neuronal and behavioral responses to different levels of predatory threat were examined in the dorsal periaqueductal grey (PAG). The results suggest that the dorsal PAG codes for different levels of predatory threat rather than orchestrating distinct threat-oriented behaviors.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Paloma Kalegari, Daniela Morais Leme, Geonildo Rodrigo Disner, Marta Margarete Cestari, Daniel de Lima Bellan, Willian Vanderlei Meira, Ester Mazepa, Glaucia Regina Martinez
Summary: The presence of higher amounts of melanin in melanoma cells may affect the levels of DNA damage when subjected to RBAc-PDT treatment.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Neurosciences
Fernando F. Melleu, Amanda R. de Oliveira, Kathleen F. Grego, D. Caroline Blanchard, Newton S. Canteras
Summary: This study examines the behavioural responses and Fos expression patterns in rats exposed to snake threats from shed snakeskin and a live snake. The findings suggest that rats exhibit different responses to odour cues and mild threat compared to a live snake. The study identifies specific neural pathways and nuclei involved in processing these threats, providing insights into the defensive mechanisms and stress adaptation in animals.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Diego Baraldi Dedino, Julliane Destro de Lima, Wanessa de C. Bortolucci, Wesley R. Rivadavea, Evellyn C. W. Lovato, Zilda C. Gazim, Jose E. Goncalves, Daisy L. R. Monzon, Glacy J. da Silva
Summary: This study investigated the effects of red light emitting diodes (LED) and different cultivation methods on the chemical composition of Acmella oleracea essential oil. The results showed that red LED light and cultivation methods significantly influenced the composition of the essential oil. Specific compounds such as trans-cariophyllene and 2-tridecanone were directly affected by the red LED light.
PLANT CELL TISSUE AND ORGAN CULTURE
(2022)
Article
Multidisciplinary Sciences
Ricardo P. Bindi, Cibele C. Guimaraes, Amanda R. de Oliveira, Fernando F. Melleu, Miguel A. X. de Lima, Marcus V. C. Baldo, Simone C. Motta, Newton S. Canteras
Summary: The present study systematically analyzed the afferent and efferent projections of the CUN and investigated its role in fear responses. The CUN was found to be a caudal component of the periaqueductal gray and had strong links with the dorsolateral periaqueductal gray. It was also found to mediate innate antipredatory responses but not learned fear responses.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Cell Biology
Ester Mazepa, Ana Luiza Dorigan de Matos Furlanetto, Hulyana Brum, Lia Sumie Nakao, Pierina Alexandra Martinez, Silvia Maria Suter Correia Cadena, Maria Eliane Merlin Rocha, Elizabeth Sousa Cunha, Glaucia Regina Martinez
Summary: In this study, we found that the activity of secreted QSOX is higher in melanoma cells and is further increased after stimulation of melanogenesis. Depleting intracellular GSH disrupts the redox homeostasis and increases oxidative stress in the cells. These findings suggest that QSOX and GSH play important roles in melanogenesis and cellular adaptive response.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Alisson Pinto de Almeida, Alicia Moraes Tamais, Carolina Zerbini, Fernando Falkenburger Melleu, Newton Sabino Canteras, Simone Cristina Motta
Summary: This study reveals the neural mechanisms involved in mediating social defensive responses. The dorsal pre-mammillary nucleus projects to the rostral dorsomedial PAG, and through ascending paths mediated by the cuneiform nucleus, it influences prosencephalic circuits to mediate passive social defensive responses. This study provides further support for the role of the PAG in the modulation of behavioral responses.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Education & Educational Research
Francislaine Aparecida dos Reis Livero, Gustavo Ratti da Silva, Eduarda Carolina Amaral, Amanda Nascimento Vasques de Souza, Irineia Paulina Baretta, Maria Elena Martins Diegues, Edson Arpini, Evellyn Claudia Wietzikoski Lovato
Summary: This study explores the application of gamification in education, specifically in teaching pharmacology in a medical course. It highlights the benefits of using gamification to increase student engagement and learning outcomes, as well as the challenges and strategies associated with integrating gamification activities into the classroom. Overall, the use of gamification in education has shown to enhance student motivation, academic participation, and overall enjoyment of classes.
EDUCATION AND INFORMATION TECHNOLOGIES
(2021)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)