Article
Behavioral Sciences
Siamak Beheshti, Hadi Dehestani
Summary: Ghrelin, a peptide primarily secreted from the stomach, has been shown to have a positive impact on memory formation. However, studies have not measured the expression levels of ghrelin or its receptors in the brain during memory formation. This study found that in fear memory formation, mRNA levels of ghrelin significantly increased 24 hours post-training while its receptors were down-regulated; in spatial memory consolidation, ghrelin expression levels remained unchanged but its receptors showed a significant increase 24 hours post-training.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Cell Biology
Wei Sun, Hong Cheng, Yang Yang, Dongxin Tang, Xiaolian Li, Lei An
Summary: The study found that the precursor pro-brain-derived neurotrophic factor (proBDNF) plays a crucial role in spatial cognition in adult rodent brains. Blocking proBDNF expression disrupted spatial memory consolidation without affecting learning or memory retrieval. The results underscore the importance of proBDNF in synaptic and cognitive functions in postnatal brains.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
N. Dolfen, B. R. King, L. Schwabe, M. A. Gann, M. P. Veldman, A. von Leupoldt, S. P. Swinnen, G. Albouy
Summary: According to the study, stress induced a larger recruitment of sensorimotor regions and a greater disengagement of hippocampo-cortical networks during training, which was beneficial for initial performance but detrimental for consolidation.
Article
Multidisciplinary Sciences
Jessica D. Creery, David J. Brang, Jason D. Arndt, Adrianna Bassard, Vernon L. Towle, James X. Tao, Shasha Wu, Sandra Rose, Peter C. Warnke, Naoum P. Issa, Ken A. Paller
Summary: This study investigates the impact of sleep on memory by measuring electrical activity in the hippocampus, and finds that the presentation of sounds during sleep enhances corresponding spatial memories, which is associated with increased specific brainwave activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Scheila Daiane Schmidt, Carolina Garrido Zinn, Lorena Evelyn Cavalcante, Flavia Fagundes Ferreira, Cristiane Regina Guerino Furini, Ivan Izquierdo, Jociane De Carvalho Myskiw
Summary: Social recognition, crucial for social group establishment, reproduction, and species survival, relies on the consolidation of social stimuli in long-term memory. This study reveals the involvement of specific serotonin receptors in the consolidation of social recognition memory, shedding light on the molecular mechanisms underlying this process.
Article
Behavioral Sciences
Ekaterina Pershina, Tatyana P. Kulagina, Tatyana A. Savina, Alexander Aripovsky, Sergey G. Levin, Vladimir Arkhipov
Summary: The study found significant changes in fatty acid levels in the prefrontal cortex and hippocampus of rats trained for a task with food reinforcement. These changes returned to control levels 72 hours after training. The reversible increase in fatty acid levels may support and protect cellular processes involved in memory acquisition.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Darryl C. Gidyk, Robert J. McDonald, Robert J. Sutherland
Summary: Results from experiments suggest that rats can maintain normal memory in adversarial learning and discrimination tasks even in the absence of the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Jessica Rosa, Jociane de Carvalho Myskiw, Natalia Gindri Fiorenza, Cristiane Regina Guerino Furini, Gerson Guilherme Sapiras, Ivan Izquierdo
Summary: This study explores the role of the hippocampal cholinergic system and mTOR in memory formation and extinction processes. The results demonstrate a dose-dependent effect of cholinergic receptor agonists on extinction memory, and the involvement of muscarinic receptors in the hippocampus independent of mTOR in this memory process.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Multidisciplinary Sciences
Thibaux Van der Stede, Laura Blancquaert, Flore Stassen, Inge Everaert, Ruud Van Thienen, Chris Vervaet, Lasse Gliemann, Ylva Hellsten, Wim Derave
Summary: Chronic blockade of histamine H-1/H-2 receptors impairs microvascular and mitochondrial adaptations to interval training in humans, leading to blunted functional adaptations in exercise capacity, glycemic control, and vascular function. This suggests that histamine H-1/H-2 receptors play a crucial role in the integrative exercise training response in humans, potentially affecting post-exercise muscle perfusion regulation.
Article
Multidisciplinary Sciences
Rajat Saxena, Justin L. Shobe, Bruce L. McNaughton
Summary: Understanding how the brain learns throughout a lifetime remains a long-standing challenge. This study explores a method of rapidly learning new information by interleaving new and old knowledge, and demonstrates its feasibility in artificial neural networks. Additionally, a theoretical model of implementing this learning approach in the brain is proposed.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Jessy D. Martinez, William P. Brancaleone, Kathryn G. Peterson, Lydia G. Wilson, Sara J. Aton
Summary: ML297, a newly developed candidate hypnotic agent, alters sleep architecture in mice and improves contextual fear memory consolidation by activating GIRK channels and increasing the number of highly activated hippocampal neurons.
Article
Pharmacology & Pharmacy
Xinhao Wang, Yize Zhao, Xiaorui Shi, Miao Gong, Ying Hao, Yaling Fu, Omar Israel Velez de-la-Paz, Xi Wang, Yuru Du, Xiangfei Guo, Li Song, Li Meng, Yuan Gao, Xi Yin, Sheng Wang, Yun Shi, Haishui Shi
Summary: This study found that the administration of exogenous SO2 derivatives has an effect on the formation of contextual fear memory, but no effect on reconsolidation and retention. This provides evidence for the development of new strategies for PTSD prevention and treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Virginie Sterpenich, Mojca K. M. van Schie, Maximilien Catsiyannis, Avinash Ramyead, Stephen Perrig, Hee-Deok Yang, Dimitri Van De Ville, Sophie Schwartz
Summary: Sleep promotes memory consolidation, with neural representations of rewarded experiences undergoing privileged reactivation during sleep, favoring their consolidation.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Larry R. Squire, Jennifer C. Frascino, Charlotte S. Rivera, Nadine C. Heyworth, Biyu J. He
Summary: One-trial, long-lasting perceptual learning relies on hippocampus-independent (nondeclarative) memory, independent of any requirement to consciously remember. Patients with hippocampal lesions or larger medial temporal lobe (MTL) lesions show intact perceptual learning but impaired memory for the images presented.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Mareike A. Gann, Nina Dolfen, Bradley R. King, Edwin M. Robertson, Genevieve Albouy
Summary: This study investigated the effect of prefrontal cortex stimulation on motor memory consolidation. The results showed that active stimulation hindered fast motor memory consolidation and altered the reactivation process in the brain, as well as the link between brain activity and behavioral markers of consolidation.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)