Article
Clinical Neurology
Joao F. C. Pedrazzi, Amanda J. Sales, Francisco S. Guimaraes, Samia R. L. Joca, Jose A. S. Crippa, Elaine Del Bel
Summary: CBD demonstrates acute antipsychotic-like effects that can last for 24 hours and has the potential to modulate DNA methylation in the brain, providing a new mechanism for its antipsychotic effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Jan Kucera, Katerina Horska, Pavel Hruska, Daniela Kuruczova, Vincenzo Micale, Jana Ruda-Kucerova, Julie Bienertova-Vasku
Summary: Schizophrenia patients have reduced life expectancy due to metabolic disturbances, with antipsychotic medications playing a major role. Research shows that antipsychotic drugs trigger dysregulation of multiple energetic and metabolic pathways in adipose tissue, particularly in schizophrenia-like animal models.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Mikael Hedberg, Sophie Imbeault, Sophie Erhardt, Lilly Schwieler
Summary: Impaired sensorimotor gating, commonly measured as disrupted prepulse inhibition (PPI) of the acoustic startle response, has been widely observed in psychotic diseases. This study found significantly lower PPI in first-episode psychosis (FEP) patients compared to healthy controls, and identified a delayed habituation in patients treated with antipsychotics.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Neurosciences
Bilgin Kaygisiz, Sule Aydin, Engin Yildirim, Ahmet Musmul, Kevser Erol, Fatma Sultan Kilic
Summary: Galangin has positive effects on cognitive deficits associated with schizophrenia, and it does not involve nicotinic, muscarinic, and serotonin-1(A) receptors. Galangin has antipsychotic-like effects without inducing catalepsy.
ACTA NEUROPSYCHIATRICA
(2022)
Article
Psychiatry
Yangsik Kim, Young Woo Noh, Kyungdeok Kim, Eunjoon Kim
Summary: The lack of IRSp53 results in decreased PPI, and the hyperactive ACC-MDT pathway suppresses PPI.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Yangsik Kim, Esther Yang, Hyun Kim
Summary: The study found that deletion of IRSp53 in mice leads to a decrease in prepulse inhibition (PPI), indicating that dysfunction of various modulatory neurons may result in PPI impairment. This suggests that PPI could be broadly affected by changes in various types of modulatory neurons.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Hisayoshi Kubota, Kazuo Kunisawa, Moe Niijima, Mami Hirakawa, Yuko Mori, Masaya Hasegawa, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri
Summary: Phencyclidine (PCP) causes mental symptoms similar to schizophrenia by inhibiting the glutamatergic system. Deficiency of kynurenine 3-monooxygenase (KMO) may be associated with exacerbation of PCP-induced symptoms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Behavioral Sciences
Yane C. P. Andrade, Jivago Ropke, Thercia G. Viana, Chiara Fanelli, Elisa Minaldi, Luara A. Batista, Ana C. Issy, Elaine A. Del Bel, Livia C. M. Rodrigues, Jean-Francois Liegeois, Fabricio A. Moreira
Summary: JL13, a novel pyridobenzoxazepine compound, shows potential as an antipsychotic drug by preventing hyperlocomotion induced by dopamine and glutamate modulators in animal models. It also demonstrates efficacy in preventing disruption of PPI caused by MK-801. This compound possesses a favorable pharmacological profile similar to second-generation antipsychotics.
BEHAVIOURAL PHARMACOLOGY
(2021)
Article
Neurosciences
Seongsik Yun, Ben Yang, Justin D. Anair, Madison M. Martin, Stefan W. Fleps, Arin Pamukcu, Nai-Hsing Yeh, Anis Contractor, Ann Kennedy, Jones G. Parker
Summary: Psychosis is associated with elevated dopamine transmission, and antipsychotic drugs are thought to rebalance the output by blocking D2 receptors. However, this study found that the efficacy of antipsychotic drugs is associated with the reversal of abnormal D1-SPN dynamics, not D2-SPN dynamics. The findings suggest that D1-SPN modulation plays an important role in the mechanism of antipsychotic drugs.
NATURE NEUROSCIENCE
(2023)
Article
Psychology, Biological
Ignasi Oliveras, Carles Tapias-Espinosa, Cristobal Rio-Alamos, Daniel Sampedro-Viana, Toni Canete, Ana Sanchez-Gonzalez, Adolf Tobena, Albertoi Fernandez-Teruel
Summary: The acoustic startle response and prepulse inhibition (PPI) are measures related to information processing in schizophrenia. This study found a PPI deficit in Roman high-avoidance (RHA) rats and genetically heterogeneous stock (HS) rats, regardless of their startle response levels. RHA rats showed poorer habituation to the startling stimulus compared to Roman low-avoidance (RLA) rats, while no differences were found in startle habituation in HS rats grouped by their baseline startle responses. These findings support the validity of RHA rats as a putative model of schizophrenia-relevant features.
BEHAVIOURAL PROCESSES
(2022)
Article
Psychiatry
Hagar Bauminger, Hiba Zaidan, Irit Akirav, Inna Gaisler-Salomon
Summary: NMDA receptor blockade in rodents can induce schizophrenia-like behavioral abnormalities, and the endocannabinoid system can modulate these abnormalities. The study shows that anandamide hydrolysis inhibitor can reverse the behavioral deficits induced by NMDA receptor blocker in adolescence. It also suggests that endocannabinoid stimulation may have therapeutic potential in treating treatment-resistant symptoms.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychiatry
Shabeesh Balan, Tetsuo Ohnishi, Akiko Watanabe, Hisako Ohba, Yoshimi Iwayama, Manabu Toyoshima, Tomonori Hara, Yasuko Hisano, Yuki Miyasaka, Tomoko Toyota, Chie Shimamoto-Mitsuyama, Motoko Maekawa, Shusuke Numata, Tetsuro Ohmori, Tomomi Shimogori, Yoshiaki Kikkawa, Takeshi Hayashi, Takeo Yoshikawa
Summary: The study reanalyzed previously identified quantitative trait loci for prepulse inhibition (PPI) and identified a PPI-regulating Cdh23 variant, as well as a possible contribution of CDH23 to schizophrenia susceptibility.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Psychology, Multidisciplinary
Ole Asli, Marta F. Johansen, Ida Solhaug
Summary: Mindfulness practice was found to increase prepulse facilitation in the study, using a prepulse inhibition/facilitation paradigm to investigate the effect on automatic attention regulation processes. The brief mindfulness exercise was shown to have an impact on startle response modulation, specifically increasing preparation for upcoming stimuli.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Behavioral Sciences
K. T. Sun, Jimmy W. Y. Lam, William C. S. Tai, Benson W. M. Lau, Benjamin K. Yee
Summary: The study found that in mouse experiments, trials showing a stronger prepulse response also exhibited a larger startle response to the subsequent pulse stimulus, indicating weaker PPI. Within-subjects and between-subjects analyses revealed contrasting relationships between the direct motor response to the prepulse and the inhibition of subsequent startle reaction induced by the same prepulse.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Psychiatry
Qijing Bo, Zhen Mao, Qing Tian, Ningbo Yang, Xianbin Li, Fang Dong, Fuchun Zhou, Liang Li, Chuanyue Wang
Summary: The study revealed that PSSPPI may serve as a promising objective approach to identify CHR individuals, who demonstrated lower PPI levels compared to healthy controls.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Psychiatry
Lior Carmi, Aron Tendler, Alexander Bystritsky, Eric Hollander, Daniel M. Blumberger, Jeff Daskalakis, Herbert Ward, Kyle Lapidus, Wayne Goodman, Leah Casuto, David Feifel, Noam Barnea-Ygael, Yiftach Roth, Abraham Zangen, Joseph Zohar
AMERICAN JOURNAL OF PSYCHIATRY
(2019)
Article
Neurosciences
Benjamin Z. Roberts, Jared W. Young, Yinong V. He, Zackary A. Cope, Paul D. Shilling, David Feifel
Review
Behavioral Sciences
Marilyn Horta, Kathryn Kaylor, David Feifel, Natalie C. Ebner
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Article
Chemistry, Medicinal
David Feifel, David Dadiomov, Kelly C. Lee
Article
Neurosciences
Moshe Isserles, Aron Tendler, Yiftach Roth, Alexander Bystritsky, Daniel M. Blumberger, Herbert Ward, David Feifel, Laura Viner, Walter Duffy, Joseph Zohar, Corey J. Keller, Mahendra T. Bhati, Amit Etkin, Mark S. George, Igor Filipcic, Kyle Lapidus, Leah Casuto, Sandeep Vaishnavi, Ahava Stein, Lisa Deutsch, Frederic Deutsch, Oscar Morales, Zafiris J. Daskalakis, Abraham Zangen, Kerry J. Ressler
Summary: This study examined the efficacy and safety of mPFC dTMS combined with exposure therapy in treating PTSD patients. Results showed significant improvement in PTSD symptoms in both groups at 5 and 9 weeks, though the dTMS group had smaller improvements. The study suggests that repeated ultrabrief exposure therapy alone may be an effective treatment for PTSD.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Jillian M. Rung, Marilyn Horta, Erin M. Tammi, Eliany Perez, Marite C. Ojeda, Tian Lin, Griffin Harris, Jessie Somerville, Dinia Salmeron, Susan E. Beltz, Bhanuprasad Sandesara, David Feifel, Natalie C. Ebner
Summary: This study investigated the safety and tolerability of chronic intranasal oxytocin in generally healthy older men, finding it to be safe and well-tolerated. These findings support further research on the potential benefits of chronic oxytocin in older adult populations.
PSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Joseph J. Taylor, Noam G. Newberger, Adam P. Stern, Angela Phillips, David Feifel, Rebecca A. Betensky, Daniel Z. Press
Summary: Seizures during rTMS treatment are rare, with a low absolute risk but a higher relative risk associated with Brainsway H-coil compared to figure-8 coil devices. Well-designed prospective studies are needed to further investigate this risk.
Article
Psychiatry
Abraham Zangen, Hagar Moshe, Diana Martinez, Noam Barnea-Ygael, Tanya Vapnik, Alexander Bystritsky, Walter Duffy, Doron Toder, Leah Casuto, Moran Lipkinsky Grosz, Edward Nunes, Herbert Ward, Aron Tendler, David Feifel, Oscar Morales, Yiftach Roth, Dan Iosifescu, Jaron Winston, Theodore Wirecki, Ahava Stein, Frederic Deutsch, Xingbao Li, Mark S. George
Summary: rTMS is a non-invasive brain stimulation method increasingly used to treat psychiatric disorders, primarily depression. Initial studies suggest that rTMS may help to treat addictions, but evaluation in multicenter randomized controlled trials (RCTs) is needed. This study establishes a safe treatment protocol that promotes smoking cessation by stimulating relevant brain circuits.
Article
Neurosciences
Peiwei Liu, Tian Lin, David Feifel, Natalie C. Ebner
Summary: Growing evidence suggests that the neuropeptide oxytocin plays a role in promoting social cognition and prosocial behavior by modulating the salience of social information. This study found that self-administered intranasal oxytocin reduced resting-state functional connectivity within the salience network, with a stronger effect observed in older participants.
Article
Psychology, Multidisciplinary
Tian Lin, Didem Pehlivanoglu, Maryam Ziaei, Peiwei Liu, Adam J. Woods, David Feifel, Hakan Fischer, Natalie C. Ebner
Summary: The study found that older adults show dampened response to faces with lower trustworthiness compared to young adults, supporting the idea of reduced sensitivity to cues of untrustworthiness in aging. Additionally, the results extend evidence of an age-related positivity effect to the evaluation of face trustworthiness.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Medicine, General & Internal
Guy M. Goodwin, Scott T. Aaronson, Oscar Alvarez, Peter C. Arden, Annie Baker, James C. Bennett, Catherine Bird, Renske E. Blom, Christine Brennan, Donna Brusch, Lisa Burke, Kete Campbell-Coker, Robin Carhart-Harris, Joseph Cattell, Aster Daniel, Charles DeBattista, Boadie W. Dunlop, Katherine Eisen, David Feifel, MacKenzie Forbes, Hannah M. Haumann, David J. Hellerstein, Astrid I. Hoppe, Muhammad I. Husain, Luke A. Jelen, Jeanine Kamphuis, Julie Kawasaki, John R. Kelly, Richard E. Key, Ronit Kishon, Stephanie Knatz Peck, Gemma Knight, Martijn H. B. Koolen, Melanie Lean, Rasmus W. Licht, Jessica L. Maples-Keller, Jan Mars, Lindsey Marwood, Martin C. McElhiney, Tammy L. Miller, Arvin Mirow, Sunil Mistry, Tanja Mletzko-Crowe, Liam N. Modlin, Rene E. Nielsen, Elizabeth M. Nielson, Sjoerd R. Offerhaus, Veronica O'Keane, Tomas Palenicek, David Printz, Marleen C. Rademaker, Aumer van Reemst, Frederick Reinholdt, Dimitris Repantis, James Rucker, Samuel Rudow, Simon Ruffell, A. John Rush, Robert A. Schoevers, Mathieu Seynaeve, Samantha Shao, Jair C. Soares, Metten Somers, Susan C. Stansfield, Diane Sterling, Aaron Strockis, Joyce Tsai, Lucy Visser, Mourad Wahba, Samuel Williams, Allan H. Young, Paula Ywema, Sidney Zisook, Ekaterina Malievskaia
Summary: Psilocybin may be effective in treating treatment-resistant depression, but dosage and adverse effects need further investigation.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Clinical Neurology
Guy M. Goodwin, Scott T. Aaronson, Oscar Alvarez, Merve Atli, James C. Bennett, Megan Croal, Charles DeBattista, Boadie W. Dunlop, David Feifel, David J. Hellerstein, Muhammad Ishrat Husain, John R. Kelly, Molly R. Lennard-Jones, Rasmus W. Licht, Lindsey Marwood, Sunil Mistry, Tomas Palenicek, Ozlem Redjep, Dimitris Repantis, Robert A. Schoevers, Batya Septimus, Hollie J. Simmons, Jair C. Soares, Metten Somers, Susan C. Stansfield, Jessica R. Stuart, Hannah H. Tadley, Nisha K. Thiara, Joyce Tsai, Mourad Wahba, Sam Williams, Rachel I. Winzer, Allan H. Young, Matthew B. Young, Sid Zisook, Ekaterina Malievskaia
Summary: This study explores the efficacy of COMP360, a synthetic formulation of psilocybin, in treating treatment-resistant depression (TRD). Results show that a single dose of psilocybin at 25 mg and 10 mg can significantly improve symptoms of depression. This study expands on previous research on the use of psilocybin in treating TRD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, Research & Experimental
Abraham Zangen, Samuel Zibman, Aron Tendler, Noam Barnea-Ygael, Uri Alyagon, Daniel M. Blumberger, Geoffrey Grammer, Hadar Shalev, Tatiana Gulevski, Tanya Vapnik, Alexander Bystritsky, Igor Filipcic, David Feifel, Ahava Stein, Frederic Deutsch, Yiftach Roth, Mark S. George
Summary: This study investigates whether targeting the medial prefrontal cortex (MPFC) using the H7 coil in deep transcranial magnetic stimulation (Deep TMS) is noninferior to targeting the lateral prefrontal cortex (LPFC) using the H1 coil. The results show that both techniques have similar clinical efficacy and safety profiles, and electrical brain activity measured by EEG correlates with clinical outcomes.
Article
Medicine, General & Internal
Terry Schwartz, Mary Ellen Trunko, David Feifel, Emily Lopez, Danika Peterson, Guido K. W. Frank, Walter Kaye
Summary: Ketamine treatment shows promise in improving depression in patients with treatment-resistant depression and enduring eating disorders.
CLINICAL CASE REPORTS
(2021)
Article
Gerontology
Ian Frazier, Tian Lin, Peiwei Liu, Sondre Skarsten, David Feifel, Natalie C. Ebner
Summary: This study found that older adults show reduced responsiveness to cues of untrustworthiness, and that oxytocin has modulatory effects on activity in the left superior temporal gyrus in older participants. Younger participants are more influenced by breach-of-trust feedback in the trust game, while older participants show more stable behavior in response to such feedback.
PSYCHOLOGY AND AGING
(2021)