期刊
BEHAVIORAL NEUROSCIENCE
卷 123, 期 3, 页码 641-649出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0015237
关键词
extinction; GABA; renewal; FG7142; extinction-test interval
资金
- Australian Postgraduate Award
- Australian Research Council [DP0346139, DP0666953]
- Australian Research Council [DP0346139, DP0666953] Funding Source: Australian Research Council
A recent finding suggested that when extinction occurs shortly after acquisition, renewal of an extinguished fear response (fear-potentiated startle) to a light conditioned stimulus (CS) is diminished (Myers, Ressler, & Davis, 2006). The present study attempted to extend this finding using a white-noise CS and freezing as the behavioral measure of fear. In Experiments I A and I B, we observed renewal whether extinction occurred 10 min or 24 hr after acquisition. In contrast, renewal was not observed if test occurred 10 min after extinction (Experiment 2). Experiment 3 demonstrated that expression of extinction at the 10-min extinction-test interval was attenuated by a pretest subcutaneous injection of the gamma-aminobutyric acid (GABA) inverse agonist FG7142. These findings suggest that renewal is influenced more by the extinction-test interval than the acquisition-extinction interval. Further, the failure to see renewal 10 min after extinction suggests that there is a separate context memory that undergoes a different consolidation function than the CS-no US memory formed during extinction. Finally, the expression of extinction appears to be GABA dependent regardless of the extinction-test interval or the test context.
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