期刊
BEHAVIORAL NEUROSCIENCE
卷 123, 期 4, 页码 894-904出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0016328
关键词
P50; marijuana; auditory gating; beta; gamma; time-frequency
资金
- NIDA [1 R03 DA019630-01, 1 R21 DA023097-01A1, T32 DA024628]
- NARSAD
Cannabis use was positively associated with high P50 ratios and negatively with post-S2 event-related spectral perturbation (ERSP) gamma power. Findings suggest that heavy cannabis use is associated with aberrant beta and gamma activity in the dual-click procedure, which corroborates recent work demonstrating central cannabinoid receptors mediate neural oscillations and are localized to networks implicated in auditory P50 sensory gating, including the hippocampus and neocortex. The current study examined whether neural oscillations evoked by the paired clicks (S1, S2) are associated with abnormal P50 gating reported in cannabis users. Seventeen heavy cannabis users and 16 cannabis naive controls participated. Analyses included P50 amplitudes, and time-frequency analyses (ERSPs; intertrial coherence, ITC). Consistent with prior studies, cannabis users exhibited reduced P50 gating. The ERSP analysis yielded attenuated high frequency activity in the beta range (13-29 Hz) post-S1 and in the gamma range (30-50 Hz) post-S2 in the cannabis group, compared with the control group. Greater levels of disruption of beta/gamma by cannabinoid receptor (CB1) agonists in a rat analogue of this task and highlights the translational potential of the dual-click procedure.
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