期刊
BEHAVIORAL NEUROSCIENCE
卷 123, 期 2, 页码 303-314出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0014988
关键词
fear; extinction; NMDA; memory
资金
- Australian Research Council [DP0877430]
- Australian Research Council [DP0877430] Funding Source: Australian Research Council
Six experiments studied the role of conditioned stimulus (CS) familiarity in determining the effects of the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 on fear extinction. Systemic administration of MK-801 (0.1 mg/kg) impaired initial extinction but not reextinction learning. MK-801 impaired reextinction learning when the CS was relatively novel during reextinction training but not initial extinction learning when the CS was relatively familiar during initial extinction training. A context change failed to reinstate the sensitivity of initial fear extinction learning about a relatively familiar CS to MK-801. These experiments show that CS familiarity is an important determinant of effects of MK-801 on fear extinction learning: MK-801 impaired extinction learning about novel stimuli but spared extinction learning about familiar stimuli.
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