期刊
BEHAVIORAL NEUROSCIENCE
卷 122, 期 4, 页码 876-884出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.122.4.876
关键词
sexual differentiation; VMH; steroidogenic factor 1; sex steroids; aggression
资金
- FIC NIH HHS [R03 TW005922] Funding Source: Medline
- NIMH NIH HHS [R01 MH057759, R01 MH057759-09, R01 MH061376-08, R01 MH061376] Funding Source: Medline
- NINDS NIH HHS [R01 NS055218-02, R01 NS055218] Funding Source: Medline
Sex hormones are a major factor responsible for the development of sex differences. Steroidogenic factor 1 (SF-1) is a key regulator of gonadal and adrenal development, and SF-I knockout mice (SF-1 KO) are born without gonads and adrenal glands. Consequently, these mice are not exposed to gonadal sex steroids. SF-1 KO pups die shortly after birth due to adrenal deficiency. In the present study, SF-1 KO mice were rescued by neonatal corticosteroid injections followed by adrenal transplantations on day 7-8 postnatally. Control mice received corticosteroid injections and were gonadectomized prior to puberty. Mice were observed interacting with ovariectomized hormone primed females and gonad-intact males. In the absence of sex steroid replacement, adult SF-1 KO mice were significantly more aggressive than control mice in tests with stimulus females. After testosterone treatment, control males displayed significantly more aggression towards male intruders than control female mice, or male and female SF-1 KO mice, suggesting a developmental role of gonadal hormones in the expression of aggressive behavior and affirming SF-1 KO mice as a behavioral model to investigate affects of fetal gonad deficiency.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据