Article
Cell Biology
Nynke Talma, Emma Gerrits, Boshi Wang, Bart J. L. Eggen, Marco Demaria
Summary: Cells expressing high levels of the CDK4/6 inhibitor p16 accumulate in aging tissues and promote age-related pathologies, particularly neurodegeneration. This study identifies two distinct subpopulations of p16-expressing microglia in the mouse brain, one associated with aging and one present in young animals, which could impact brain homeostasis, function, and disease positively or negatively.
Article
Behavioral Sciences
Chang S. Han, Gawon Yang
Summary: Reproductive aging patterns vary among individuals and are related to behavior, with virgin females showing significant quadratic reproductive aging patterns and those investing more in early reproduction experiencing a sharper decline in egg production in later life.
BEHAVIORAL ECOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ryo Terao, Tazbir Ahmed, Ayana Suzumura, Hiroko Terasaki
Summary: Aging leads to a decline in organ function, including the eyes, resulting in age-related ocular diseases. Cellular senescence, characterized by cell cycle arrest, plays a significant role in aging and age-related diseases by altering cellular function and secretory phenotypes. Oxidative stress triggers cellular senescence and age-related diseases by inducing senescence markers through reactive oxygen species and mitochondrial dysfunction.
Article
Plant Sciences
Changming Chen, Yael Galon, Maryam Rahmati Ishka, Shimrit Malihi, Vladislava Shimanovsky, Shir Twito, Abhishek Rath, Olena K. Vatamaniuk, Gad Miller
Summary: APX6 is identified as a senescence-associated gene specifically induced in aging leaves and in response to senescence-promoting stimuli. Mutants of apx6 exhibit early developmental senescence and increased sensitivity to dark stress. Age-dependent post-transcriptional regulation of APX6 and its potential interaction with miR398 and copper redistribution pathways are important for ROS/redox homeostasis and signaling in aging leaves.
Article
Biochemistry & Molecular Biology
Boying Zhao, Jiang Yu, Yuan Luo, Ming Xie, Can Qu, Qiong Shi, Xiaowen Wang, Xingji Zhao, Lingwen Kong, Yu Zhao, Yongzheng Guo
Summary: S100A9 plays a crucial role in the inflammatory response and contributes to aging-related pathologies and endothelial dysfunction. The deficiency of S100A9 alleviates vascular senescence, improves insulin resistance, reduces oxidative stress and inflammation in aged mice. The study suggests that targeting the S100A9/TLR4 signaling pathway may be a potential therapeutic strategy to prevent age-related cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Marta Zietek, Katarzyna Barlowska, Barbara Wijas, Ewa Szablisty, Atanas G. Atanasov, Jacek A. Modlinski, Artur H. Swiergiel, Silvestre Sampino
Summary: Preconceptional resveratrol supplementation improved mating success and prevented delivery complications in old female mice, but had less significant effects on mid-aged females. These results suggest that preconceptional RES supplementation could partially improve age-related reproductive complications.
Review
Cell Biology
Lena Guerrero-Navarro, Pidder Jansen-Durr, Maria Cavinato
Summary: Organismal aging is associated with an increase in senescent cells, which disrupt normal tissue function. Cellular organelle damage and lysosomal dysfunction are crucial factors in regulating cellular behavior during aging.
Article
Multidisciplinary Sciences
Fernando A. Campos, Jeanne Altmann, Marina Cords, Linda M. Fedigan, Richard Lawler, Elizabeth Lonsdorf, Tara S. Stoinski, Karen B. Strier, Anne M. Bronikowski, Anne E. Pusey, Susan C. Alberts
Summary: Through studying seven long-term continuous primate populations, we found that age has a significant impact on female reproductive performance and offspring survival in most species. This includes longer inter-birth intervals, reduced number of completed interbirth intervals, and lower survival rates among offspring born to older mothers. Maternal age also affects the age at which daughters first reproduce, particularly in species with female-biased dispersal.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Pierre Comizzoli, Mary Ann Ottinger
Summary: Reproductive aging is observed in wild species, and this study aims to highlight the importance of comparative research in addressing aging issues in conservation breeding and human reproductive medicine. While many traits are conserved across species, there are also unique features, and further research is needed to understand cellular and molecular processes during reproductive aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Yu Zhang, Yanyun Li, Yuanyuan Zhang, Zeyu Zhang, Deyu Zhang, Xiaonan Wang, Binfan Lai, Dandan Huang, Lianfeng Gu, Yakun Xie, Ying Miao
Summary: In this study, we investigated the role of H3K9ac in the regulation of gene expression during flag leaf aging in rice, and identified a complex regulatory network involving metabolism- and senescence-related pathways.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Review
Neurosciences
Dilara Hasavci, Thomas Blank
Summary: Recent studies have shown that age-related diseases such as Alzheimer's and Parkinson's disease, as well as other brain disorders, are associated with changes in the gut microbiome. Aging is a major factor that affects the composition of the microbiome, and levels of microbiota-derived metabolites are elevated in older individuals with age-associated diseases. These metabolites can trigger the immune response in the central nervous system by influencing the development and activation status of brain-resident macrophages.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Anthony Lagnado, Jack Leslie, Marie-Helene Ruchaud-Sparagano, Stella Victorelli, Petra Hirsova, Mikolaj Ogrodnik, Amy L. Collins, Maria Grazia Vizioli, Leena Habiballa, Gabriele Saretzki, Shane A. Evans, Hanna Salmonowicz, Adam Hruby, Daniel Geh, Kevin D. Pavelko, David Dolan, Helen L. Reeves, Sushma Grellscheid, Colin H. Wilson, Sanjay Pandanaboyana, Madison Doolittle, Thomas von Zglinicki, Fiona Oakley, Suchira Gallage, Caroline L. Wilson, Jodie Birch, Bernadette Carroll, James Chapman, Mathias Heikenwalder, Nicola Neretti, Sundeep Khosla, Claudio Akio Masuda, Tamar Tchkonia, James L. Kirkland, Diana Jurk, Derek A. Mann, Joao F. Passos
Summary: The research shows that neutrophils cause oxidative damage to telomeres in non-immune cells, promoting cellular senescence. In aged liver, senescent cells recruit neutrophils, potentially leading to the spread of senescence.
Article
Food Science & Technology
Pedro Ferreira-Santos, Rosalia Carron, M. Jose Montero, M. Angeles Sevilla
Summary: Lycopene treatment improved age-associated harmful changes in hypertension, cardiovascular and renal remodeling, and indicators of oxidant-antioxidant systems in both young and adult SHR.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Ecology
Peter M. Kappeler, Leonie Pethig, Lea Prox, Claudia Fichtel
Summary: The relationship between age and reproductive performance varies greatly among different species. This study examined age-related reproductive performance in two populations of Malagasy primates and found evidence of reproductive senescence in three out of four populations. The study also revealed the influence of rainfall on reproductive output in one species but not the other.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Biochemistry & Molecular Biology
Brittney G. Borowiec, Michael P. Wilkie
Summary: This study investigates the interactions between senescence, oxidative stress, and metabolic function in sea lamprey. It reveals that sea lamprey experience greater oxidative stress with age and suggests a possible role of mitochondrial dysfunction in the senescence of sea lamprey.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jose Carlos Noguera, Alberto da Silva, Alberto Velando
Summary: Maternal glucocorticoids can have lasting effects on offspring phenotype and survival by influencing embryo telomerase activity and postnatal telomere length.
Article
Ecology
Nayade alvarez-Quintero, Alberto Velando, Jose C. Noguera, Sin-Yeon Kim
Summary: The study on three-spined stickleback revealed that changes in reproductive strategies in response to environmental cues can impact offspring's growth and survival. When females experience a late breeding photoperiod, they reduce investment in early clutches, while males increase investment in sexual signals.
ECOLOGY AND EVOLUTION
(2021)
Article
Ecology
J. G. Calado, S. N. Verissimo, V. H. Paiva, R. Ramos, P. T. Vaz, D. Matos, J. Pereira, C. Lopes, N. Oliveira, A. Quaresma, F. R. Ceia, A. Velando, J. A. Ramos
Summary: The research highlighted the importance of fish in the diet of two gull species, which matched the fish landed by local fisheries. The study suggested that gull feeding ecology was linked to fishery discards, with different feeding strategies observed in relation to fisheries. Implications for gull populations across Europe were noted due to the EU landing obligation.
MARINE ECOLOGY PROGRESS SERIES
(2021)
Article
Behavioral Sciences
Nayade Alvarez-Quintero, Alberto Velando, Sin-Yeon Kim
Summary: This study investigated the role of cognitive abilities in sexual selection in three-spined sticklebacks. Results showed that females prefer males with high cognitive abilities, and this preference is influenced by the females' own cognitive abilities. Additionally, males with higher cognitive abilities built more elaborate nests but displayed weaker nuptial coloration. This suggests that cognitive traits of both sexes play a role in influencing female mate preference in this species.
BEHAVIORAL ECOLOGY
(2021)
Article
Biology
Jose C. Noguera, Alberto Velando
Summary: The study found that telomerase activity in blood cells of a wild yellow-legged gull population is not negligible, but sharply declines from hatching to fledging, leading to a reduction in telomere length. The results indicate that fast growth negatively affects telomerase activity, influencing telomere dynamics and potentially life-history trajectories.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Biology
Sin-Yeon Kim, Violette Chiara, Nayade Alvarez-Quintero, Alberto Velando
Summary: The high level of mtDNA content in animal oocytes helps prevent the transmission of detrimental mutations to the next generation. Variation in oocyte mtDNA levels can impact offspring development and viability.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Behavioral Sciences
Francisco Ruiz-Raya, Alberto Velando
Summary: The prenatal light environment has a significant impact on the development of shy-bold phenotypes in yellow-legged gull hatchlings. Prenatal light exposure promotes bolder behavior and the lateralization of begging behavior in hatchlings, which is negatively associated with boldness. Changes in glucocorticoid levels induced by light exposure do not affect the chicks' personality.
Article
Behavioral Sciences
Francisco Ruiz-Raya, Jose C. Noguera, Alberto Velando
Summary: The prenatal light environment can shape the phenotype and behavior of avian embryos, with light cues promoting the development of resilient junior chicks that can buffer competitive disadvantages associated with hatching asynchrony.
BEHAVIORAL ECOLOGY
(2022)
Article
Ecology
Jose C. Noguera, Alberto Velando
Summary: Studies have shown that maternal testosterone levels affect telomerase levels and growth in yellow-legged gull chicks. The effects of maternal testosterone on telomere length disappear by day 6 post-hatching. These findings suggest that maternal testosterone may have an adaptive value in promoting offspring growth and telomerase levels.
ECOLOGY AND EVOLUTION
(2022)
Article
Microbiology
Maider Justel-Diez, Erick Delgadillo-Nuno, Alberto Gutierrez-Barral, Paula Garcia-Otero, Isaac Alonso-Barciela, Pablo Pereira-Villanueva, Xose Anton Alvarez-Salgado, Alberto Velando, Eva Teira, Emilio Fernandez
Summary: This study investigated the role of seabird guano in marine ecosystem functioning by adding different concentrations of gull guano to microbial communities collected from coastal waters in NW Spain. Results showed that guano stimulated the growth of certain bacteria and diatoms, and increased chlorophyll a concentration. The study also revealed that guano altered the phytoplankton-bacteria interaction from neutral to positive in low-nutrient environments, but from positive to neutral in high-nutrient environments.
ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Behavioral Sciences
Francisco Ruiz-Raya, Jose C. Noguera, Alberto Velando
Summary: This study investigates the relationship between hormone levels and gene expression during maternal and infant development, and finds that the covariation between corticosterone and glucocorticoid receptor gene expression in blood can impact embryonic development and postnatal phenotypes.
HORMONES AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Sin-Yeon Kim, Violette Chiara, Nayade Alvarez-Quintero, Alberto da Silva, Alberto Velando
Summary: Maternal effect senescence refers to a decline in offspring viability with maternal age, and its mechanisms in animals remain largely unknown. In this study, the researchers tested this phenomenon in stickleback fish and explored its molecular mechanisms. They found that old females transferred fewer mRNA transcripts of DNA repair genes to their eggs compared to young females, suggesting a reduced capacity of eggs to detect and repair DNA damages. However, maternal age did not influence egg mtDNA density. The offspring of old mothers showed higher rates of hatching, morphological deformity, and post-hatching mortality, indicating the negative impact of maternal effect senescence.
Article
Ornithology
Mauricio Guillen-Parra, Alberto Velando, Rocio Barcenas-Flores, Leticia Nicolas-Toledo, Roxana Torres
Summary: Telomere length (TLS) may serve as an indicator of individual quality, influencing mating preferences and breeding patterns. Studies on the Brown Booby bird revealed a positive correlation between TLS and mitochondrial DNA copy number (mtDNAcn), suggesting a reduced mitochondrial density in individuals with shorter telomeres. TLS was also associated with sexual coloration, but only in colonies with favorable breeding conditions. Positive assortative mating by TLS was found, but the degree of assortative mating did not affect the likelihood of mate change. These findings highlight the influence of environmental variation on mating patterns and the importance of TLS as an integrative indicator of individual quality.
Article
Ecology
Violette Chiara, Alberto Velando, Sin-Yeon Kim
Summary: This study investigates the link between physiological traits and sexual traits in the three-spined stickleback. The results indicate that nest-building and courtship behavior in male sticklebacks are not related to their metabolic rates, swim ability, oxidative damage, or mtDNA copy number. However, males with larger red nuptial color areas have higher levels of oxidative DNA damage in their sperm. Male courtship behavior and aggressiveness, but not red color area, predict offspring hatching and survival.
BMC ECOLOGY AND EVOLUTION
(2022)
Article
Biology
Alberto Velando, Jose Carlos Noguera, Manuel Aira, Jorge Dominguez
Summary: The length of telomeres in hatchlings is related to the composition of the microbiome, with potential commensal bacteria contributing to longer telomeres. However, this relationship is not affected by treatment with the stress hormone corticosterone.