Review
Behavioral Sciences
Salar Vaseghi, Mohammad Nasehi, Mohammad-Reza Zarrindast
Summary: Cannabinoids interact with multiple neurotransmitters in learning and memory, yielding unpredictable effects, with mechanisms that require further investigation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
D'bora Dreher Nabinger, Stefani Altenhofen, Alexis Buatois, Amanda Facciol, Julia Vasconcellos Peixoto, Julia Maria Kuhl da Silva, Diptendu Chatterjee, Gabriel Rubensam, Robert Gerlai, Carla Denise Bonan
Summary: This study investigated the effects of the dopamine D2/D3 receptor agonist quinpirole on the behavior, brain-derived neurotrophic factor (BDNF), and neurotransmitter levels in adult zebrafish. The results showed that quinpirole administration caused decreased locomotor activity, increased anxiety-like behaviors, memory impairment, and stereotypic swimming in zebrafish. Furthermore, quinpirole treatment also decreased the number of BDNF-immunoreactive cells and altered glutamate and serotonin levels in the zebrafish brain. These findings suggest that quinpirole administration in adult zebrafish can be a useful tool for studying the mechanisms underlying neurological disorders related to the dopaminergic system.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Dmitrii S. Traktirov, Ilya R. Nazarov, Valeria S. Artemova, Raul R. Gainetdinov, Nina S. Pestereva, Marina N. Karpenko
Summary: This article explores the roles of dopamine and serotonin in the central nervous system and the impact of knockout of the DAT gene on neurotransmission. The study reveals that excessive dopamine leads to dysregulation of neurotransmission in multiple brain regions and significant effects on the serotonin system. These findings highlight the importance of considering these factors in drug therapies.
Article
Biochemistry & Molecular Biology
Atiah H. Almalki, Ibrahim A. Naguib, Fahad S. Alshehri, Badrah S. Alghamdi, Hashem O. Alsaab, Yusuf S. Althobaiti, Sameer Alshehri, Fatma F. Abdallah
Summary: This study compared seven published chromatographic methods and found that Method 6 was the optimal choice for analyzing mixtures due to its high greenness, wide application scope, and high sensitivity.
Review
Neurosciences
Tingyan Wu, Weili Cai, Xi Chen
Summary: Neurotransmission signaling is a conserved system with important regulatory events. The role of excitatory and inhibitory neurotransmitter systems in brain function is well established. Recent research has shown that epigenetic regulation plays a crucial role in controlling the expression of neurotransmitter-related genes and its dysregulation is associated with neurological disorders. This article explores the epigenetic regulation of dopamine, GABA, glutamate, and serotonin genes, and discusses how targeting these mechanisms can lead to improved treatments for neurological disorders.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Medicine, Research & Experimental
Tia A. Griffith, Jake S. Russell, Saba Naghipour, Tessa J. Helman, Jason N. Peart, Nicolas J. C. Stapelberg, John P. Headrick, Eugene F. Du Toit
Summary: This study found that mice with type 2 diabetes (T2D) exhibited anxiety-like behavior, which was independent of body weight and blood glucose levels but may be related to resistance to leptin. Dietary n-3 polyunsaturated fatty acid (PUFA) did not show significant metabolic or behavioral benefits in T2D mice.
Article
Biochemistry & Molecular Biology
Ester Anton-Galindo, Elisa Dalla Vecchia, Javier G. Orlandi, Gustavo Castro, Emilio J. Gualda, Andrew M. J. Young, Marc Guasch-Piqueras, Concepcio Arenas, Carlos Herrera-Ubeda, Jordi Garcia-Fernandez, Fernando Aguado, Pablo Loza-Alvarez, Bru Cormand, William H. J. Norton, Noelia Fernandez-Castillo
Summary: Genetic variants in YWHAZ contribute to neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. Using zebrafish as a model, researchers found that YWHAZ is expressed widely in neurons during development and limited to Purkinje cells in the adult cerebellum. Knocking out YWHAZ resulted in altered neuronal activity and connectivity in the hindbrain, decreased monoamine levels, and freeze behavior in adult fish, which could be reversed with drugs targeting monoamine neurotransmission.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Alaa M. Hammad, Ala A. Alhusban, Lujain F. Alzaghari, Fawaz Alasmari, Youssef Sari
Summary: Cigarette smoke withdrawal can cause anxiety-like behavior and modulate neurotransmitter-related proteins in the brain. The concentrations of neurotransmitters in the amygdala and hippocampus were examined after cigarette smoke exposure with and without aspirin treatment. The results showed that cigarette smoke withdrawal induced anxiety behaviors and increased tissue content of dopamine, serotonin, glutamate, glutamine, and GABA, while aspirin treatment reduced anxiety and reversed the effects of cigarette smoke exposure on neurotransmitter levels.
Review
Biochemistry & Molecular Biology
Ariel Frajerman, Linda Scoriels, Oussama Kebir, Boris Chaumette
Summary: Schizophrenia typically emerges during adolescence and the detailed pathophysiology and treatment of the disease remain relatively unknown. Antipsychotics are effective for first episode psychosis and chronic schizophrenia, but not for ultra-high risk patients. Omega-3 supplementation has shown potential benefits in preventing and treating schizophrenia in early stages by modulating various biological systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Miriam Ouadih-Moran, Antonio Munoz-Hoyos, Luis D'Marco, Antonio Molina-Carballo, Isabel Seiquer, Ana Checa-Ros
Summary: This study found that ADHD patients had significantly increased levels of S100B, and that S100B concentrations gradually increased after triple therapy. These results support the hypothesis of a neuroinflammatory basis in ADHD and the damaging effect on glial function.
Review
Biochemistry & Molecular Biology
Jolyon A. Jones, Katharina Zuhlsdorff, Jeffrey W. Dalley
Summary: Drug addiction is manifested in some individuals and involves multifaceted processes such as cognitive control failures. Impulsivity, which includes reckless behavior without foresight, underlies most drug-taking behavior. While the neural substrates of the relationship between trait impulsivity and drug compulsion are poorly understood, advances have been made in studying limbic cortico-striatal circuits and neuromodulatory influences.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Neurosciences
Kara K. Cover, Brian N. Mathur
Summary: The chemical synapse is the primary form of contact between neurons in the central nervous system, with axo-axonic synapses being an atypical type that play significant roles in neural signaling and functional neural circuit motifs.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Pharmacology & Pharmacy
Ghulam Yahya Amiry, Murtaza Haidary, Hassan Azhdari-Zarmehri, Farimah Beheshti, S. Mohammad Ahmadi-Soleimani
Summary: In this study, we investigated the effects of adolescent nicotine exposure and subsequent abstinence on anxiety and depressive behaviors in rats. Nicotine withdrawal exacerbated anxiety behaviors through changes in oxidative stress balance, inflammatory response, and serotonin metabolism. Omega-3 fatty acid pre-treatment significantly prevented nicotine withdrawal-induced complications by restoring the mentioned biochemical changes. Overall, we suggest omega-3 fatty acid supplementation as a safe, inexpensive, and effective strategy for preventing or ameliorating detrimental effects caused by nicotine withdrawal at the cellular and behavioral levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Kristi Liiver, Sophie Imbeault, Marianna Skolnaja, Tanel Kaart, Margus Kanarik, Karita Laugus, Jade De Wettinck, Aleksander Pulver, Ruth Shimmo, Jaanus Harro
Summary: Sex differences in exploratory behavior were observed in male and female rats. Female rats displayed higher exploratory activity and a normal distribution, while males exhibited a bimodal distribution. There were no major effects of litter or estrous cycle. Differences in monoamine metabolism between male and female rats were found, including lower dopamine levels in the frontal cortex and higher levels of 3,4-dihydroxyphenylacetic acid (DOPAC) in the raphe area in males. Females had higher levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the dorsal striatum, but lower levels in the locus coeruleus area. There were also differences in noradrenaline (NA) and normetanephrine (NMN) levels between the sexes. Female rats displayed not only higher levels of exploration, but also a distinct population distribution of this behavior, which may be related to differences in monoaminergic systems.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Maeri Yamamoto, Toshiya Inada
Summary: ADHD is a neurodevelopmental disorder characterized by inattention, hyperactivity, impulsivity, and cognitive dysfunction. PET studies have not identified characteristic findings for diagnosing ADHD, although disturbances in dopamine, serotonin, and norepinephrine functions have been implicated. Previous PET studies have shown altered binding of dopamine markers in the basal ganglia, but no consistent results were observed for dopamine transporters and receptors. PET studies with ligands related to serotonin and norepinephrine pathways have shown unclear clinical significance or low replicability. Further research is needed to determine characteristic findings for diagnosing ADHD, particularly with new active ligands.
JAPANESE JOURNAL OF RADIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hanne Frus Berntsen, Frode Fonnum, Sven Ivar Walaas, Inger Lise Bogen
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2016)
Article
Medicine, Legal
Merete Vevelstad, Elisabeth Leere Oiestad, Sara Bremer, Inger Lise Bogen, Anna-Lena Zackrisson, Marianne Arnestad
FORENSIC SCIENCE INTERNATIONAL
(2016)
Article
Biochemical Research Methods
Marianne Skov-Skov Bergh, Inger Lise Bogen, Elsa Lundanes, Ase Marit Leere Oiestad
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2016)
Article
Pharmacology & Pharmacy
H. F. Berntsen, I. L. Bogen, M. B. Wigestrand, F. Fonnum, S. I. Walaas, A. Moldes-Anaya
Article
Biochemical Research Methods
Marianne Skov-Skov Bergh, Inger Lise Bogen, Jannike Morch Andersen, Ase Marit Leere Oiestad, Thomas Berg
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2018)
Article
Multidisciplinary Sciences
Matti Viluksela, Paivi Heikkinen, Leo T. M. van der Ven, Filip Rendel, Robert Roos, Javier Esteban, Merja Korkalainen, Sanna Lensu, Hanna M. Miettinen, Kari Savolainen, Satu Sankari, Hellmuth Lilienthal, Annika Adamsson, Jorma Toppari, Maria Herlin, Mikko Finnila, Juha Tuukkanen, Heather A. Leslie, Timo Hamers, Gerd Hamscher, Lauy Al-Anati, Ulla Stenius, Kine-Susann Dervola, Inger-Lise Bogen, Frode Fonnum, Patrik L. Andersson, Dieter Schrenk, Krister Halldin, Helen Hakansson
Article
Medical Laboratory Technology
Marianne Skov-Skov Bergh, Inger Lise Bogen, Steven Ray Wilson, Ase Marit Leere Oiestad
THERAPEUTIC DRUG MONITORING
(2018)
Article
Pharmacology & Pharmacy
Anne Marte Sjursen Kvello, Jannike Morch Andersen, Elisabeth Leere Oiestad, Synne Steinsland, Audun Aase, Jorg Morland, Inger Lise Bogen
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2019)
Article
Biochemistry & Molecular Biology
Anne Marte Sjursen Kvello, Jannike Morch Andersen, Fernando Boix, Jorg Morland, Inger Lise Bogen
Article
Toxicology
Marianne Skov-Skov Bergh, Inger Lise Bogen, Elisabeth Nerem, Ariane Wohlfarth, Steven Ray Wilson, Ase Marit Leere Oiestad
Summary: This study aimed to discover and elucidate the major metabolites of three novel fentanyl analogues, providing important markers for confirming the intake of these compounds in forensic cases.
FORENSIC TOXICOLOGY
(2021)
Article
Substance Abuse
Jannike M. Andersen, Inger Lise Bogen, Ritva Karinen, Gerd Wenche Brochmann, Jorg Morland, Vigdis Vindenes, Fernando Boix
Summary: The study showed that the preparation process of heroin for intravenous injection can alter the concentration of diacetylmorphine and its active metabolites, 6-acetylmorphine and morphine in the final product, which may lead to unintended variations in potency of the injected solution.
Article
Pharmacology & Pharmacy
Inger Lise Bogen, Fernando Boix, Jannike Morch Andersen, Synne Steinsland, Elisabeth Nerem, Jorg Morland
Summary: Immunotherapeutic interventions that bind drug molecules to specific antibodies in the bloodstream have shown promising effects in blocking drug effects, particularly for heroin. The metabolism of heroin and the role of specific antibodies were investigated using state-of-the-art analytical methodology in freshly drawn human whole blood incubated with different concentrations of heroin. The study revealed that blood enzymes play a more important role in the rapid metabolism of heroin in humans than previously assumed, suggesting that targeting 6-AM with immunotherapy could be an efficient approach to block heroin effects in humans.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Merete Vevelstad, Elisabeth Leere Oiestad, Elisabeth Nerem, Marianne Arnestad, Inger Lise Bogen
DRUG METABOLISM AND DISPOSITION
(2017)
Article
Pharmacology & Pharmacy
Anne Marte Sjursen Kvello, Jannike Morch Andersen, Elisabeth Leere Oiestad, Jorg Morland, Inger Lise Bogen
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2016)
Article
Pharmacology & Pharmacy
Inger Lise Bogen, Fernando Boix, Elisabeth Nerem, Jorg Morland, Jannike Morch Andersen
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2014)