Review
Multidisciplinary Sciences
Zheng Jiang, Zidong Chen, Xi Chen
Summary: This article reviews the research on gene-environment interactions in substance use and finds that certain genes have significant interaction effects under specific environmental factors. The diathesis-stress model is the most common interaction pattern observed. The article suggests that future studies should use consistent study designs and measures, control for confounding factors, and generate theory-based hypotheses.
Article
Behavioral Sciences
Macarena Gonzalez-Portilla, Susana Mellado, Sandra Montagud-Romero, Fernando Rodriguez de Fonseca, Maria Pascual, Marta Rodriguez-Arias
Summary: This study evaluated the effects of oleoylethanolamide (OEA) on the rewarding properties of cocaine and relapse-related gene expression in the striatum and hippocampus. The results showed that OEA did not affect cocaine-induced conditioned place preference acquisition, but it blocked drug-induced reinstatement and inhibited the expression of dopamine receptor gene D1, dopamine receptor gene D2, and cannabinoid receptor 1 in the striatum and hippocampus. These findings suggest that OEA may be a promising pharmacological agent in the treatment of cocaine use disorder.
BEHAVIORAL AND BRAIN FUNCTIONS
(2023)
Review
Neurosciences
Melinda Hersey, Amanda K. Bacon, Lydia G. Bailey, Mark A. Coggiano, Amy H. Newman, Lorenzo Leggio, Gianluigi Tanda
Summary: The rapid increase in individuals affected by psychostimulant use disorder (PSUD) has highlighted the potential of Modafinil (MOD) as a therapeutic option due to its non-addictive properties, despite its similar mechanism of action to commonly abused psychostimulants on the dopamine transporter (DAT). Clinical and preclinical studies have demonstrated the efficacy of MOD in treating symptoms related to PSUD and other psychiatric disorders involving alterations of brain dopamine systems.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Melinda Hersey, Mattingly K. Bartole, Claire S. Jones, Amy Hauck Newman, Gianluigi Tanda
Summary: Psychostimulant use disorders (PSUD) have significant public health and economic burdens, with sex differences observed in dependence onset, relapse rates, and treatment success. These differences may be related to neurochemical differences in the dopaminergic system, with females showing greater effects during the high estradiol phase. Women are more likely to start drug use at younger ages and exhibit higher desire for cocaine compared to men. Modafinil, a DAT inhibitor used for narcolepsy and sleep disorders, shows promise in treating PSUD, and its therapeutic potential is discussed in this review.
Article
Behavioral Sciences
Kunlin Zhang, Guanyu Ji, Mei Zhao, Yan Wang
Summary: piRNAs regulate gene expression in response to methionine treatment in cocaine-induced behaviors, involving genes related to substance dependence, signal transduction, and nervous functions pathways. The study showed that piRNAs negatively regulate target mRNA genes and positively regulate target miRNA genes. These findings may explain the mechanisms of methionine in counteracting the effects of cocaine CPP.
BRAIN AND BEHAVIOR
(2021)
Article
Biology
Xiaojie Liu, Casey R. Vickstrom, Hao Yu, Shuai Liu, Shana Terai Snarrenberg, Vladislav Friedman, Lianwei Mu, Bixuan Chen, Thomas J. Kelly, David A. Baker, Qing-song Liu
Summary: This study demonstrates that Epac2 in the mesolimbic dopamine system promotes cocaine reinforcement by enhancing dopamine release. Conditional knockout or inhibition of Epac2 reduces cocaine self-administration in mice, while Epac2 agonism increases dopamine release. This mechanism plays a crucial role in the reinforcing effects of cocaine.
Article
Multidisciplinary Sciences
Julong Wei, Tova Y. Lambert, Aditi Valada, Nikhil Patel, Kellie Walker, Jayna Lenders, Carl J. Schmidt, Marina Iskhakova, Adnan Alazizi, Henriette Mair-Meijers, Deborah C. Mash, Francesca Luca, Roger Pique-Regi, Michael J. Bannon, Schahram Akbarian
Summary: This study found that chronic exposure to opioids results in broad transcriptional changes in glial cells, including upregulation of genes associated with immune response and downregulation of synaptic signaling and plasticity genes. It also identified certain genes that are linked to risk of substance use in the population.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Lidia E. W. Spelta, Yuli Y. S. Torres, Sarah C. W. S. E. F. de Oliveira, Mauricio Yonamine, Alexis Bailey, Rosana Camarini, Raphael C. T. Garcia, Tania Marcourakis
Summary: This study demonstrates that cocaine use induces plastic changes in the hippocampal cholinergic muscarinic system, while withdrawal leads to a resetting of the system.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Ma Luisa Soto-Montenegro, Veronica Garcia-Vazquez, Nicolas Lamanna-Rama, Gonzalo Lopez-Montoya, Manuel Desco, Emilio Ambrosio
Summary: Vulnerability to addiction is associated with the risk of developing an addiction during an individual's lifetime. This study used PET and SPM techniques to investigate changes in brain glucose metabolism in response to chronic morphine self-administration in two rat strains with different vulnerability to drug abuse. The results showed significant differences in brain metabolic patterns between the two strains, suggesting variations in the efficiency of neural substrates in translating the effects of the drug.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
David D. Kim, Ric M. Procyshyn, Andrea A. Jones, Lik Hang N. Lee, William J. Panenka, Jacob L. Stubbs, Lianne L. Cho, Olga Leonova, Kristina M. Gicas, Allen E. Thornton, Donna J. Lang, William Macewan, William G. Honer, Alasdair M. Barr
Summary: This study aimed to determine the proportion and severity of movement disorders (MDs) in precariously housed and homeless individuals, and their associations with substance use. The study found that 18.6% of the sample had clinically relevant signs of MDs, and the severity of MDs was significantly associated with the frequency and dependence of methamphetamine use.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
James R. Melchior, Rafael E. Perez, Gregory J. Salimando, Joseph R. Luchsinger, Aakash Basu, Danny G. Winder
Summary: This study reveals a dopamine-mediated cellular inhibition mechanism in the dBNST, suggesting that dopamine terminal autoreceptor activation and dopamine transporter blockade can affect the duration of catecholamine signals. Furthermore, cocaine enhances cellular inhibition in the dBNST in a drug reinforcement paradigm.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Pengju Yan, Ningning Li, Ming Ma, Zhaoli Liu, Huicui Yang, Jinnan Li, Chunlei Wan, Shuliu Gao, Shuai Li, Longtai Zheng, John L. Waddington, Lin Xu, Xuechu Zhen
Summary: This study reveals that roxadustat upregulates HIF-1α expression, resulting in cellular iron deficiency and functional accumulation of dopamine transporter (DAT), which inhibits conditioned place preference (CPP) induced by morphine or methamphetamine (METH).
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biology
Gregg Wildenberg, Anastasia Sorokina, Jessica Koranda, Alexis Monical, Chad Heer, Mark Sheffield, Xiaoxi Zhuang, Daniel McGehee, Bobby Kasthuri
Summary: The study utilized large volume serial electron microscopy to reveal detailed information on dopamine neuron connections in the NAc of mice, showing significant structural changes in DA axons after exposure to cocaine, including formation of spinule-like structures with neighboring neurons. The findings suggest that DA axonal transmission is unlikely to be mediated through classical synapses, with extensive axonal re-arrangements and changes in mitochondria being the major locus of anatomical plasticity in DA circuits after cocaine exposure.
Article
Neurosciences
Wendy J. Lynch, Anousheh Bakhti-Suroosh, Jean M. Abel, Camilla Davis
Summary: The study found that addiction development involves a shift from dopamine D1 receptor signaling to glutamate receptor signaling, while dopamine D2 receptor remains crucial in motivating cocaine use. Motivation for cocaine is higher in addiction-like phenotype. The response to pharmacological treatment depends on the dose and addiction status.
PSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Soo Min Lee, Han Byeol Jang, Yu Fan, Bong Hyo Lee, Sang Chan Kim, Kyle B. Bills, Scott C. Steffensen, Hee Young Kim
Summary: Nociceptive signals modulate the mesolimbic reward system, possibly through the involvement of the lateral hypothalamus (LH) and lateral habenula (LHb). Stimulation by tail pinch excites LHb and LH neurons, leading to increased inhibitory activity on the mesolimbic dopamine (DA) system. This inhibition is essential for attenuating cocaine-induced behaviors and drug reinstatement.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Psychiatry
Jiayi Cox, Richard Sherva, Leah Wetherill, Tatiana Foroud, Howard J. Edenberg, Henry R. Kranzler, Joel Gelernter, Lindsay A. Farrer
Summary: The study found stimulant dependence to be heritable, with potential genetic factors and genes underlying the trait identified through a genome-wide association study. Four suggestive loci were identified, with genes related to other substance use disorders also being highlighted.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Alexander S. Hatoum, Emma C. Johnson, Sarah M. C. Colbert, Renato Polimanti, Hang Zhou, Raymond K. Walters, Joel Gelernter, Howard J. Edenberg, Ryan Bogdan, Arpana Agrawal
Summary: Shared genetic liability partly explains susceptibility to alcohol, tobacco, cannabis, and opioid use disorders. The Addiction-Risk-Factor is associated with risk-taking, neuroticism, executive function, and non-substance psychopathology, retaining specific variance even after accounting for the genetics of substance use.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Bo Hu, Jungwon Cha, Janice M. Fullerton, Sonia Hesam-Shariati, Kunio Nakamura, John Nurnberger, Amit Anand
Summary: We investigated gene-environment effects on structural brain endophenotype in bipolar disorder using a novel method of combining polygenic risk scores with epigenetic signatures. The study found that the methylation profile score was negatively associated with the volume of the medial geniculate thalamus, while family history, trauma scale, and polygenic risk score were not associated with any brain measures.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Sivaprakasam R. Saroja, Kirill Gorbachev, T. C. W. Julia, Alison M. Goate, Ana C. Pereira
Summary: A protein called glypican-4 (GPC-4) secreted by astrocytes is shown to drive tau hyperphosphorylation induced by APOE4, a genetic risk factor for Alzheimer's disease. This discovery provides insights into the mechanisms underlying tauopathies and highlights the role of GPC-4 in tau accumulation and propagation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Psychiatry
Dongbing Lai, Tae-Hwi Schwantes-An, Marco Abreu, Grace Chan, Victor Hesselbrock, Chella Kamarajan, Yunlong Liu, Jacquelyn L. Meyers, John I. Jr Jr Nurnberger, Martin H. Plawecki, Leah Wetherill, Marc Schuckit, Pengyue Zhang, Howard J. Edenberg, Bernice Porjesz, Arpana Agrawal, Tatiana Foroud
Summary: This study proposes a gene-based polygenic risk score (PRSgene) to improve the evaluation of alcohol use disorder (AUD) risk in African Americans (AA). By using variants located within disease-associated genes to calculate PRSgene, it was found to be significantly associated with AUD in both AA and European ancestry (EA) populations and outperformed PRS calculated using all variants in AA. The study provides new insights into AUD genetics and identifies potential drug targets for AUD treatment.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Hetal Patel, Justin Barnes, Nosayaba Osazuwa-Peters, Laura Jean Bierut
Summary: Despite overall increases in suicide rates in both groups, the Medicaid expansion states showed a smaller increase in suicide rates among nonelderly adults compared to nonexpansion states. This difference may be attributed to improved access to mental health care, highlighting the importance of suicide prevention as a benefit of expanding healthcare access.
Article
Psychology, Clinical
Jinni Su, Sally I-Chun Kuo, Angel Trevino, Peter B. Barr, Fazil Aliev, Kathleen Bucholz, Grace Chan, Howard J. Edenberg, Samuel Kuperman, Dongbing Lai, Jacquelyn L. Meyers, Gayathri Pandey, Bernice Porjesz, Danielle M. Dick
Summary: Higher parental educational attainment is associated with higher offspring educational attainment. This study examined the genetic and socioenvironmental pathways underlying this association using data from individuals of European ancestry. The results showed that the genetic scores of paternal and maternal educational attainment were associated with offspring educational attainment, and parental educational attainment, income, and parenting behaviors mediated this effect.
JOURNAL OF FAMILY PSYCHOLOGY
(2022)
Review
Neurosciences
Carmen Romero-Molina, Francesca Garretti, Shea J. Andrews, Edoardo Marcora, Alison M. Goate
Summary: Genome-wide association studies and functional genomics studies have provided insights into the role of specific cell types, genes, and pathways in the risk of Alzheimer's disease (AD), particularly highlighting the involvement of microglia in AD pathogenesis.
Article
Genetics & Heredity
Mohamed Abdulkadir, Jay A. Tischfield, Gary A. Heiman, Pieter J. Hoekstra, Andrea Dietrich
Summary: The combination of polygenic risk score (PRS) and pregnancy-related factors can better explain the occurrence of tics. The cumulative adverse pregnancy risk score mediated the association between maternal anxiety, depression, smoking, and tics.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2023)
Article
Public, Environmental & Occupational Health
Sarah Gehlert, Vaughan W. Rees, Kelvin Choi, Peter D. Jackson, Brynn E. Sheehan, Richard A. Grucza, Amy C. Paulson, Andrew D. Plunk
Summary: This study aimed to better understand the inequitable impact of the pandemic by examining the associations between stay-at-home orders and indoor smoking in public housing, measured by ambient particulate matter at the 2.5-micron threshold, a marker for secondhand smoke. The study found that stay-at-home orders led to increased indoor secondhand smoke in public housing, highlighting the disproportionate impact on socio-economically disadvantaged communities.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Editorial Material
Neurosciences
Laura J. Bierut
BIOLOGICAL PSYCHIATRY
(2023)
Article
Mathematics, Interdisciplinary Applications
Susanne Bruins, Jouke-Jan Hottenga, Michael C. Neale, Rene Pool, Dorret I. Boomsma, Conor V. Dolan
Summary: Genotype-environment interaction refers to the moderation of genetic effects by the environment or environmental effects by genes on a phenotype. This article introduces genotype-environment interaction models and proposes a test based on the classical twin design. Simulation studies and empirical data analysis demonstrate the feasibility of this approach for detecting genotype-environment interaction, although its power depends on the heritability of the phenotype and the strength of genetic effects.
MULTIVARIATE BEHAVIORAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Chenglong Yu, Andrew Bakshi, Gerald F. Watts, Alan E. Renton, Brian Fulton-Howard, Alison M. Goate, Pradeep Natarajan, Daniel I. Chasman, Liubov Robman, Robyn L. Woods, Robyn Guymer, Rory Wolfe, Le Thi Phuong Thao, John J. Mcneil, Andrew M. Tonkin, Stephen J. Nicholls, Paul Lacaze
Summary: The study identified genetic variants in the CETP gene region associated with cardiovascular resilience during aging, individuals carrying these variants had better lipid profiles and reduced risk of ASCVD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Neurosciences
John Nurnberger Jr, Yumin Wang, Yong Zang, Dongbing Lai, Leah Wetherill, Howard J. Edenberg, Fazil Aliev, Martin H. Plawecki, David Chorlian, Grace Chan, Kathleen Bucholz, Lance Bauer, Chella Kamarajan, Jessica E. Salvatore, Manav Kapoor, Victor Hesselbrock, Danielle Dick, Laura Bierut, Vivia McCutcheon, Jacquelyn L. Meyers, Bernice Porjesz, John Kramer, Samuel Kuperman, Sivan Kinreich, Andrey P. Anokhin
Summary: This study found that European ancestry subjects with higher PRS were more likely to develop AUD, with predictive power primarily driven by clinical variables. In a high-risk sample, European ancestry subjects with PRS in the highest quartile showed a higher risk for developing AUD.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2022)
Article
Health Care Sciences & Services
Andrew C. Qi, Karen E. Joynt Maddox, Laura J. Bierut, Kenton J. Johnston
Summary: This cross-sectional study compared the performance of psychiatrists vs other outpatient physicians in Medicare's Merit-Based Incentive Payment System. The findings showed that psychiatrists had lower performance scores, were more likely to receive penalties, and were less likely to receive bonuses compared to other physicians.
