期刊
BEHAVIOR GENETICS
卷 42, 期 1, 页码 121-132出版社
SPRINGER
DOI: 10.1007/s10519-011-9482-1
关键词
Gene-environment interaction; Child and adolescent depression; Maternal depression; Single nucleotide polymorphism
资金
- MRC [G9810900] Funding Source: UKRI
- Medical Research Council [G9810900] Funding Source: Medline
- Economic and Social Research Council [RES-000-23-1380] Funding Source: researchfish
- Medical Research Council [G0801418B] Funding Source: researchfish
- The Sir Jules Thorn Charitable Trust [06JTA] Funding Source: researchfish
This study investigated moderation of the association between recurrent maternal depression and offspring depression symptoms by a selection of biologically relevant gene variants. 271 children/adolescents (aged 9.00 to 16.00 years) whose mothers had experienced at least two episodes of DSM-IV major depression and 165 controls (aged 12.25 to 16.67 years) drawn from a population-based twin register were used. Seven single nucleotide polymorphisms (SNPs) from three genes were genotyped in children. The genes were the Corticotropin Receptor Type 1 gene (CRHR1), the gene coding for the FK506 binding protein 5 (FKBP5) and the Glucocorticoid receptor gene (NR3c1) along with a haplotype formed by the SNPs in CRHR1. A significant association was found between recurrent maternal depression and depression symptoms in offspring. None of the SNPs were associated with offspring depression symptoms and associations did not differ according to the presence of recurrent maternal depression. However, caution is required due to a relatively small sample size.
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