Article
Plant Sciences
Krishnan P. Abhijith, S. Gopala Krishnan, Kuram Tirumala Ravikiran, Gaurav Dhawan, Pankaj Kumar, Kunnummal Kurungara Vinod, Prolay Kumar Bhowmick, Mariappan Nagarajan, Rakesh Seth, Ritesh Sharma, Sourav Kumar Badhran, Haritha Bollinedi, Ranjith Kumar Ellur, Ashok Kumar Singh
Summary: This is the first GWAS study in Basmati rice, identifying 32 unique MTAs including 11 robust MTAs for agronomic traits and 25 unique MTAs for grain quality traits, with 6 of them being novel. Six candidate genes associated with the robust MTAs were identified through genome annotation.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Chao-Yu Guo, Reng-Hong Wang, Hsin-Chou Yang
Summary: The study introduces a novel method for detecting gene and gene-environment interactions in complex family-based association studies and develops an R function to implement this new strategy. The use of this method can unveil family-based joint effects, with simulation studies confirming its validity and superior statistical power.
SCIENTIFIC REPORTS
(2021)
Article
Fisheries
Mingxu Chu, Yongyi Jia, Zhaowen Wu, Hengqing Huan, Xinping Guo, Shaowu Yin, Kai Zhang
Summary: The study identified and characterized the IGF1, IGF2, and IGF3 genes in hybrid yellow catfish. The IGF genes were found to be evolutionarily-constrained and conserved in their function. Transcriptional studies showed that the three IGF genes were most abundant in the liver and exhibited different expression patterns during embryogenesis and larval development. Association analysis revealed a significant association between a specific SNP in IGF2 and nine growth traits in the catfish. These findings highlight the importance of the IGF system in mediating growth development and provide a potential marker for breeding.
AQUACULTURE REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Johanna L. Smith, Miranda L. Wilson, Sara M. Nilson, Troy N. Rowan, Robert D. Schnabel, Jared E. Decker, Christopher M. Seabury
Summary: In this study, genotypic information and heritability estimates were used to identify genomic regions associated with growth traits in Red Angus cattle. Pleiotropic QTL regions were discovered, and positional candidate genes previously associated with feed efficiency and growth traits in beef cattle were also found to be associated with Red Angus growth traits. Additionally, significant genotype-by-environment (GxE) interactions were detected, implicating the role of vasodilation, metabolism, and the nervous system in genetic sensitivity to environmental stress.
Article
Genetics & Heredity
Jorge Velazquez-Roman, Uriel A. Angulo-Zamudio, Nidia Leon-Sicairos, Hector Flores-Villasenor, Miriam Benitez-Baez, Ana Espinoza-Salomon, Alejandra Karam-Leon, Hugo Villamil-Ramirez, Samuel Canizales-Quinteros, Luis Macias-Kauffer, Jose Monroy-Higuera, Erika Acosta-Smith, Adrian Canizalez-Roman
Summary: Metabolic diseases are significant public health challenges globally, and genetic variants may play a crucial role. This study found significant associations between allelic variants of PCSK1 and anthropometric traits, obesity, and metabolic syndrome.
Article
Multidisciplinary Sciences
Qinqin Jin, Gang Shi
Summary: A random effect model overlapping MR method is proposed in this study, which simultaneously considers heterogeneity and overlapping data, showing high efficiency in SNP-environment interaction studies.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Nayoung Ro, Mesfin Haile, Bichsaem Kim, Gyu-Taek Cho, Jungro Lee, Yoon-Jung Lee, Do Yoon Hyun
Summary: This study established a core collection of eggplant genetic resources and identified SNPs associated with important agro-morphological traits. The findings are valuable for the selection and breeding programs of eggplant genetic resources.
Article
Plant Sciences
Alba Alvarez-Morezuelas, Leire Barandalla, Enrique Ritter, Jose Ignacio Ruiz de Galarreta
Summary: In this study, 144 tetraploid potato genotypes were evaluated to investigate the variation of physiological and agronomic traits under control and water stress conditions. A total of 18 SNP markers significantly associated with these traits were identified, providing insights into the mechanisms of potato tolerance to water stress and potential markers for marker-assisted selection programs.
Article
Biochemistry & Molecular Biology
Seong-Hoon Kim, Rupesh Tayade, Byeong-Hee Kang, Bum-Soo Hahn, Bo-Keun Ha, Yoon-Ha Kim
Summary: This study conducted a genome-wide association study (GWAS) on 357 soybean landraces to analyze root traits. It identified 112 significant SNP loci and 55 putative candidate genes. These findings suggest that the combined approach of SNP array and GWAS can be used to understand the genetic basis of soybean root traits and improve soybean breeding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agronomy
Shamseldeen Eltaher, Ahmed Sallam, Hamdy A. Emara, Ahmed A. Nower, Khaled F. M. Salem, Andreas Boerner, P. Stephen Baenziger, Amira M. Mourad
Summary: Wheat is a crucial crop with high genetic variation in yield traits. GWAS identified significant SNP markers associated with yield traits, but no common markers were found between different environments.
Article
Multidisciplinary Sciences
Muhammad Moaeen-ud-Din, Raja Danish Muner, Muhammad Sajjad Khan
Summary: This study aimed to identify genomic regions influencing growth and body conformation traits among Punjab goat breeds by performing GWAS using 50K SNP Chip. We identified a number of highly significant SNPs and candidate genes associated with growth and body conformation traits, indicating their potential role in body growth. Pleiotropic effects were also observed for some SNPs for body weight and conformation traits.
SCIENTIFIC REPORTS
(2022)
Article
Fisheries
Fenqi Zhu, Huibang Sun, Liming Jiang, Quanqi Zhang, Jinxiang Liu
Summary: In this study, whole genome resequencing was used to genotype 716 individuals of Trachinotus ovatus, resulting in the identification of 4,886,850 high-quality single nucleotide polymorphisms (SNPs). A genome-wide association study (GWAS) revealed 107 significant SNPs and 108 related genes associated with growth traits such as body weight and body length. The identified SNPs and genes were found to be significantly enriched in terms related to muscle growth, anabolism, and bone development. This study provides valuable insights into the genetic architecture of growth-related traits and offers molecular markers for future genome-wide selection breeding of T. ovatus.
Article
Agronomy
Brittney H. Jones, Nancy K. Blake, Hwa-Young Heo, John M. Martin, Jessica A. Torrion, Luther E. Talbert
Summary: Investigation of allele effects for four yield component quantitative trait loci under different resource availability levels provides guidance for improving grain yield in high and low yielding environments. Results show that leveraging yield component QTL can lead to significant positive impacts on grain yield and yield component traits when resource availability is increased.
THEORETICAL AND APPLIED GENETICS
(2021)
Article
Genetics & Heredity
Qing Wang, Ning Yan, Hao Chen, Sirui Li, Haiyan Hu, Yu Lin, Haoran Shi, Kunyu Zhou, Xiaojun Jiang, Shifan Yu, Caixia Li, Guangdeng Chen, Zisong Yang, Yaxi Liu
Summary: This study identified two subpopulations within 223 Aegilops tauschii accessions and discovered 66 significant markers associated with kernel traits on a genome-wide level using population structure analysis and genome-wide association analysis.
FRONTIERS IN GENETICS
(2021)
Article
Biotechnology & Applied Microbiology
Farhad Hormozdiari, Junghyun Jung, Eleazar Eskin, Jong Wha J. Joo
Summary: The MARS method increases the power of detecting true associated risk loci compared to previous approaches by considering the causal status of variants.
Article
Psychology, Developmental
Hema Sekhar Reddy Rajula, Mirko Manchia, Kratika Agarwal, Wonuola A. Akingbuwa, Andrea G. Allegrini, Elizabeth Diemer, Sabrina Doering, Elis Haan, Eshim S. Jami, Ville Karhunen, Marica Leone, Laura Schellhas, Ashley Thompson, Stephanie M. van den Berg, Sarah E. Bergen, Ralf Kuja-Halkola, Anke R. Hammerschlag, Marjo Riitta Jarvelin, Amy Leval, Paul Lichtenstein, Sebastian Lundstrom, Matteo Mauri, Marcus R. Munafo, David Myers, Robert Plomin, Kaili Rimfeld, Henning Tiemeier, Eivind Ystrom, Vassilios Fanos, Meike Bartels, Christel M. Middeldorp
Summary: CAPICE is an EU-funded training network focused on investigating the causes of childhood and adolescent psychopathology, particularly depression, anxiety, and ADHD. The network brings together multiple birth and childhood cohorts to study the environmental and genetic factors influencing these mental health issues.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Francesca Procopio, Quan Zhou, Ziye Wang, Agnieska Gidziela, Kaili Rimfeld, Margherita Malanchini, Robert Plomin
Summary: Most research on individual differences in cognitive ability focuses on general cognitive ability (g), with less known about the genetics of the middle level of the Cattell-Horn-Carroll (CHC) model. This meta-analytic review of twin studies found that specific cognitive abilities (SCA) have an average heritability of 56%, similar to g. However, there is substantial differential heritability across different SCAs and they do not show the developmental increase seen for g. Surprisingly, SCA independent of g still remain substantially heritable.
Article
Medicine, General & Internal
Rustam N. Mustafin, Anastasiya V. Kazantseva, Yulia V. Kovas, Elza K. Khusnutdinova
Summary: Retroelements play a crucial role in the neurological complications and long-term effects of COVID-19. The virus alters the expression of retroelements in neurons, resulting in persistent viral presence and subsequent neurological consequences. Research on specific retroelements can aid in the development of targeted miRNA therapies, as the changes in neuronal genome function caused by transposons are reversible.
RUSSIAN OPEN MEDICAL JOURNAL
(2022)
Article
Genetics & Heredity
Wonuola A. Akingbuwa, Anke R. Hammerschlag, Andrea G. Allegrini, Hannah Sallis, Ralf Kuja-Halkola, Kaili Rimfeld, Paul Lichtenstein, Sebastian Lundstrom, Marcus R. Munafo, Robert Plomin, Michel G. Nivard, Meike Bartels, Christel M. Middeldorp
Summary: Genetic factors partially explain the associations between childhood psychopathology and adult outcomes. Specific adult traits are genetically associated with childhood psychopathology, such as major depression being associated with ADHD, internalizing problems, and social problems. Additionally, educational attainment, BMI, and neuroticism have genetic associations with specific childhood phenotypes, while bipolar disorder, subjective well-being, and insomnia are not associated with any childhood traits.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2023)
Review
Behavioral Sciences
Robert Plomin
Summary: This review looks back on the journey of behavioral genetic research and celebrates milestones, focusing on the last fifty years. The advent of DNA microarrays enabled genome-wide association studies, which successfully identified DNA variants contributing to the heritability of behavioral traits. The DNA revolution in the behavioral sciences allows for the prediction of individual differences in behavior from early in life.
Article
Psychology, Developmental
Agnieszka Gidziela, Margherita Malanchini, Kaili Rimfeld, Andrew McMillan, Angelica Ronald, Essi Viding, Alison Pike, Kathryn Asbury, Thalia C. Eley, Sophie von Stumm, Robert Plomin
Summary: Individual differences in symptoms of behavior problems in childhood and adolescence are primarily due to non-shared environment (NSE), and few specific environmental factors have been found to account for these differences. Home and classroom environments are more likely to influence behavior problem symptoms via genetics than via NSE.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Maxim Likhanov, Olga Bogdanova, Evgenia Alenina, Tatiana Kolienko, Yulia Kovas
Summary: Spatial ability (SA) has been found to be an important predictor of success in various educational contexts, including STEM. While there is limited evidence suggesting that learning character-based languages like Chinese as a second language (CSL) might improve SA, this study with a sample of Russian schoolchildren (N = 283) found no significant differences in SA levels between groups of students who learned different language pairs. Regression analysis showed that SA was primarily predicted by intelligence and gender rather than the language learned. Further research is needed to investigate other factors that may potentially moderate the link between CSL learning and SA improvement.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Ziada Ayorech, Jessie R. Baldwin, Jean-Baptiste Pingault, Kaili Rimfeld, Robert Plomin
Summary: This study examines the association between media use and mental health, finding that negative media use is correlated with poor mental health, while general media use is correlated with prosocial behavior and fewer behavioral problems. The study suggests that genetically informed designs should be adopted to strengthen causal inference in research on the mental health impact of media use.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Veera M. Rajagopal, Andrea Ganna, Jonathan R. Coleman, Andrea Allegrini, Georgios Voloudakis, Jakob Grove, Thomas D. Als, Henriette T. Horsdal, Liselotte Petersen, Vivek Appadurai, Andrew Schork, Alfonso Buil, Cynthia M. Bulik, Jonas Bybjerg-Grauholm, Marie Baekvad-Hansen, David M. Hougaard, Ole Mors, Merete Nordentoft, Thomas Werge, Preben Bo Mortensen, Gerome Breen, Panos Roussos, Robert Plomin, Esben Agerbo, Anders D. Borglum, Ditte Demontis
Summary: Individuals with psychiatric disorders show cognitive differences compared to the general population, which can be observed early in school performance and are genetically influenced. A genome-wide association study revealed a strong negative correlation between math performance and risk for most psychiatric disorders, while language performance correlated positively with risk for certain disorders, especially schizophrenia. Furthermore, genetic variants related to schizophrenia risk and better language performance are more common in individuals involved in creative professions compared to the general population. These findings suggest a potential genetic overlap between language ability, creativity, and psychopathology.
SCIENTIFIC REPORTS
(2023)
Correction
Psychology, Multidisciplinary
Yu L. L. Luo, Yulia Kovas, Lizhong Wang, Anastasios Stalikas, Theodoros A. Kyriazos, Foteini-Maria Gianniou, Maxim V. Likhanov, Kostas A. Papageorgiou
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Educational
Nicolas Ruth, Elina Tsigeman, Maxim Likhanov, Yulia Kovas, Daniel Muellensiefen
Summary: People who engage in musical activities tend to have certain personality traits, especially openness. There are associations between different aspects of music and personality, with the strongest link being between emotions in music and openness.
PSYCHOLOGY OF MUSIC
(2023)
Article
Genetics & Heredity
Akiko Yoshida, Tomoharu Tokutomi, Akimune Fukushima, Robert Chapman, Fatos Selita, Yulia Kovas, Makoto Sasaki
Summary: Knowledge of genetics is crucial for understanding genetic testing and its implications. Recent genomic research allows us to predict the risk of common diseases based on individual genomic information. However, there is currently no measure of genetic knowledge that includes post-genome sequencing advancements in Japan.
Article
Multidisciplinary Sciences
Elina S. Tsigeman, Maxim V. Likhanov, Anna V. Budakova, Aydar Akmalov, Ildar Sabitov, Evgeniia Alenina, Ksenia Bartseva, Yulia Kovas
Summary: Background: Spatial ability shows wide variability, and one explanation for this variability is interest and engagement in activities that promote spatial ability. Previous studies have identified various activities that may contribute to individual and gender differences in spatial ability, including tinkering with electronics, sports activities, and designing. However, the findings regarding these links are inconsistent. Aim: This study aimed to evaluate these links by comparing spatial ability in adolescents with expertise in STEM, arts, and sports, with their unselected peers. The study also aimed to assess whether gender differences in spatial ability are present in expert groups. Results: Only STEM experts consistently outperformed the unselected group on spatial ability tasks, while arts and sports experts did not show such improvement. Gender differences in spatial ability persisted in all expert groups, with moderate effect sizes. Discussion: The findings support the links between spatial ability and STEM-related expertise, but not arts and sports expertise. Gender differences in spatial ability were present across all samples, even in STEM experts.
Article
Biotechnology & Applied Microbiology
Fatos Selita, Robert Chapman, Yulia Kovas, Vanessa Smereczynska, Maxim Likhanov, Teemu Toivainen
Summary: Timely and effective regulation is crucial for genetic advances, especially in the context of justice systems. A study found that Supreme Court judges in Romania had stronger endorsement and more consistent views on the use of genetic data and technologies compared to other justice stakeholders. Judges and lawyers widely recognized the need for amending relevant laws to ensure appropriate regulation.
NEW GENETICS AND SOCIETY
(2023)
Article
Psychology, Educational
Vlada Repeykova, Teemu Toivainen, Maxim Likhanov, Kim Van Broekhoven, Yulia Kovas
Summary: This study investigated sex differences in creativity among 984 high achieving adolescents in three expertise areas: Sciences, Arts, and Sports. The results showed negligible sex differences overall, with females performing better in AUT fluency and males self-rating their creative self-efficacy higher. However, some stereotypical differences emerged in mechanical/scientific and artistic creativity.
JOURNAL OF CREATIVE BEHAVIOR
(2023)
