Article
Multidisciplinary Sciences
Vincent Michaud, Eulalie Lasseaux, David J. Green, Dave T. Gerrard, Claudio Plaisant, Tomas Fitzgerald, Ewan Birney, Benoit Arveiler, Graeme C. Black, Panagiotis Sergouniotis
Summary: By studying a large cohort of individuals with albinism, researchers identified common and rare gene variants associated with the disorder, indicating a complex genetic architecture.
NATURE COMMUNICATIONS
(2022)
Letter
Zoology
Takao UKAJI, Masahiro A. IWASA, Osamu KAI
Summary: We established a PCR-RFLP analysis targeting the R77H mutation in the Tyrgene, as a more effective genotyping method to identify carriers (C/c) with the albino allele and agouti phenotypes. This breeding system targeting the R77H site serves as a useful cue for detecting C/c carriers with the agouti phenotype and facilitates obtaining albinos by mating agouti-phenotype carriers.
INTEGRATIVE ZOOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jie Liu, Xiaotong Sun, Hongtao Nie, Jahan Kifat, Jinlong Li, Zhongming Huo, Jinhong Bi, Xiwu Yan
Summary: The study identified 21 tyrosinase genes in Ruditapes philippinarum, which were found to be involved in the immune response of the clam. The findings suggest that tyrosinase genes play a role in immune defense and potential immune functions in R. philippinarum.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2021)
Article
Biochemistry & Molecular Biology
Marcin Piechota, Urszula Skupio, Malgorzata Borczyk, Barbara Ziolkowska, Slawomir Golda, Lukasz Szumiec, Klaudia Szklarczyk-Smolana, Wiktor Bilecki, Jan Manuel Rodriguez Parkitna, Michal Korostynski
Summary: The expression of Ca2+/Calmodulin-Dependent Protein Kinase I gamma (Camk1g) is regulated by stress and glucocorticoid receptors (GR) in neuronal cells of the limbic system. It is involved in anxiety-related behaviors and responses conditioned by aversive stimuli.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Fei Zhang, Deborah Velez-Irizarry, Catherine W. Ernst, Wen Huang
Summary: In this study, genome-wide analysis of alternative splicing in skeletal muscle of a Duroc x Pietrain F2 pig population was performed. It was found that the heritability of alternative splicing scores was lower than that of overall gene expression. Additionally, there was little correlation between alternative splicing and overall gene expression. Integration of splice QTL mapping with phenotype QTL mapping identified potential mediators of phenotype QTL effects through alternative splicing.
Article
Biology
Arrate Sevilla, Ana Sanchez-Diez, Sofia Cobo, Neskuts Izagirre, Conrado Martinez-Cadenas, Rosa M. Marti, Teresa Puertolas, Blanca de Unamuno, Jose Banuls, Rosa Izu, Jesus Gardeazabal, Aintzane Asumendi, Maria D. Boyano, Santos Alonso
Summary: The rs1042602-A allele within the TYR gene is associated with susceptibility to melanoma and a poorer prognosis, particularly in men.
Article
Psychology, Biological
Jelena M. Wehrli, Yanfang Xia, Samuel Gerster, Dominik R. Bach
Summary: Trace fear conditioning is an important research paradigm for studying aversive learning, but the optimal measurement of memory retention is unclear. This study used psychophysiological measurements to investigate CS+ and CS- differentiation in a recall test, and found that fear-potentiated startle response was the most effective measure.
Article
Cell Biology
Meng-Shiun Wu, Ting-Wei Liao, Chun-Yuan Wu, Tzu-Han Hsieh, Ping-Chung Kuo, Yue-Chiun Li, Kuan-Chung Cheng, Hsueh-Cheng Chiang
Summary: Animals acquire surrounding information for appropriate behavior through social learning and self-learning. However, the regulatory mechanism of social learning, especially in transmitting aversive conditioning information, is still unknown. This study revealed species-dependent differences in how observer flies process aversive conditioning information acquired from demonstrator flies during social learning. Solitary flies, on the other hand, cannot learn this information through social learning, suggesting it is not an innate behavior.
Article
Behavioral Sciences
D. Zeid, L. R. Seemiller, D. A. Wagstaff, T. J. Gould
Summary: This study investigated the phenotypic constructs underlying contextual fear conditioning and correlated behaviors in mice. The results identified unique constructs related to anxiety, fear learning, activity/exploration, post-shock freezing, and open field activity. The findings provide insights into the biological mechanisms underlying fear learning and individual differences in fear- and learning-related behaviors in mice.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2023)
Article
Chemistry, Multidisciplinary
Qiu-Ling Zhang, Diwei Zheng, Xue Dong, Pei Pan, Si-Min Zeng, Fan Gao, Si-Xue Cheng, Xian-Zheng Zhang
Summary: Immunotherapy presents a promising strategy for cancer treatment, but systemic inhibition of antigen presentation limits its effectiveness. A tumor protein-engineering system based on the DFY tripeptide was developed to collect and deliver tumor proteins to immune cells, enhancing immune response. This system successfully enriched and transported tumor antigen-containing proteins in melanoma cells and suppressed tumor growth and recurrence in murine melanoma study.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Mitjan Morr, Jeanine Noell, Daphne Sassin, Jule Daniels, Alexandra Philipsen, Benjamin Becker, Birgit Stoffel-Wagner, Rene Hurlemann, Dirk Scheele
Summary: Loneliness may contribute to vulnerability to intrusive memories after trauma in healthy men, with altered limbic processing of fear signals being a potential underlying mechanism. Lonely men showed more intrusions and altered amygdala activity, while loneliness did not have the same impact on women.
Article
Pharmacology & Pharmacy
Shihao Huang, Yu Zhou, Feilong Wu, Cuijie Shi, He Yan, Liangpei Chen, Chang Yang, Yixiao Luo
Summary: This study found that berberine combined with extinction training can effectively promote the extinction of fear memories and prevent their reinstatement and spontaneous recovery. This finding provides a new potential avenue for the treatment of fear-related disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Vipada Kantayos, Jin-Suk Kim, So-Hyeon Baek
Summary: Resveratrol and its derivatives, including piceid, show potential health-related biological activities. Resveratrol production is uncommon in plants, leading to the development of resveratrol-enriched rice (DJ526) for its nutritional and therapeutic value. Elicitation using various elicitors can enhance resveratrol production, with jasmonic acid and MeJA showing strong elicitation effects. These elicitors can also elicit biological activities, such as anti-melanogenic activities, in DJ526 cell suspension.
Article
Ecology
Juan A. Galarza
Summary: Coloration is a crucial adaptation for the survival and reproduction of many species, particularly aposematic species that rely on their coloring as a warning signal. While most research focuses on the evolution of warning coloration through natural selection, little is known about color mutants of aposematic species at the genomic level. The study on albino mutant caterpillars of the aposematic wood tiger moth revealed disruptions in melanin synthesis and structural deficiencies in cuticular may contribute to the albino condition.
ECOLOGY AND EVOLUTION
(2021)
Article
Genetics & Heredity
Takayuki Ochiai, Marina Sakaguchi, Shin-Ichi Kawakami, Akira Ishikawa
Summary: An integrated approach of transcriptome, haplotype frequency, and association analyses was used to identify candidate genes for the QTL affecting innate fear behavioral traits in chickens. The initial QTL interval on chromosome 4 contained 333 genes, but through further analysis, the number of candidate genes was reduced to 11, with NPY5R and LOC101749214 identified as strong candidates for innate fear behavior.
G3-GENES GENOMES GENETICS
(2023)
Article
Genetics & Heredity
Xinzhu Zhou, Celine L. St Pierre, Natalia M. Gonzales, Jennifer Zou, Riyan Cheng, Apurva S. Chitre, Greta Sokoloff, Abraham A. Palmer
G3-GENES GENOMES GENETICS
(2020)
Article
Neurosciences
Sandra Sanchez-Roige, Abraham A. Palmer
NATURE NEUROSCIENCE
(2020)
Article
Genetics & Heredity
Alexander F. Gileta, Jianjun Gao, Apurva S. Chitre, Hannah Bimschleger, Celine L. St Pierre, Shyam Gopalakrishnan, Abraham A. Palmer
G3-GENES GENOMES GENETICS
(2020)
Editorial Material
Neurosciences
Chloe J. Jordan, Abraham A. Palmer
NEUROPSYCHOPHARMACOLOGY
(2020)
Correction
Neurosciences
Chloe J. Jordan, Abraham A. Palmer
NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Genetics & Heredity
Christoph D. Rau, Natalia M. Gonzales, Joshua S. Bloom, Danny Park, Julien Ayroles, Abraham A. Palmer, Aldons J. Lusis, Noah Zaitlen
Article
Behavioral Sciences
Xinzhu Zhou, Amanda M. Barkley-Levenson, Patricia Montilla-Perez, Francesca Telese, Abraham A. Palmer
Summary: The study aimed to investigate the role of Azi2 in methamphetamine sensitivity by creating mutant Azi2 alleles and analyzing their effects on the locomotor response to methamphetamine. While the mutant allele increased sensitivity, contrary to GWAS results, lower Azi2 levels did not necessarily decrease the response. Despite no direct correlation between Azi2 and Slc6a3, the Azi2 mutation altered the expression of important genes and pathways related to methamphetamine sensitivity.
GENES BRAIN AND BEHAVIOR
(2021)
Article
Substance Abuse
Spencer B. Huggett, Emma C. Johnson, Alexander S. Hatoum, Dongbing Lai, Jenani Srijeyanthan, Jason A. Bubier, Elissa J. Chesler, Arpana Agrawal, Abraham A. Palmer, Howard J. Edenberg, Rohan H. C. Palmer
Summary: The study demonstrates that rodent gene expression studies can help identify genetic contributions to some substance use traits in humans, but with less specificity than expected. The results show that rodent gene-sets are enriched for specific traits in human GWAS, with enrichment increasing as trait heritability increases.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Psychology, Clinical
E. E. Levitt, A. Oshri, M. Amlung, L. A. Ray, S. Sanchez-Roige, A. A. Palmer, J. MacKillop
Summary: This study examines the relationship between delay discounting and multiple psychiatric conditions and finds significant associations between delay discounting and several disorders. The findings provide support for delay discounting as a transdiagnostic indicator and suggest further research is warranted.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Genetics & Heredity
Jennifer Zou, Shyam Gopalakrishnan, Clarissa C. Parker, Jerome Nicod, Richard Mott, Na Cai, Arimantas Lionikas, Robert W. Davies, Abraham A. Palmer, Jonathan Flint
Summary: Combining samples in genetic association studies for complex traits can identify more loci, but replication between studies may be challenging. The Winner's Curse effect, study heterogeneity, and trait differences are factors that affect replication, and integrating various information can assign variants to different confidence levels.
G3-GENES GENOMES GENETICS
(2022)
Article
Behavioral Sciences
Sandra Sanchez-Roige, Samuel A. Barnes, Jazlene Mallari, Rebecca Wood, Oksana Polesskaya, Abraham A. Palmer
Summary: The membrane glycoprotein M6B (Gpm6b) is involved in neuronal differentiation, myelination, and inactivation of the serotonin transporter. Recent studies have shown its association with psychiatric disorders. A mutant allele of Gpm6b was created in mice, leading to deficits in delay discounting but enhanced reward sensitivity and behavioral flexibility.
GENES BRAIN AND BEHAVIOR
(2022)
Article
Multidisciplinary Sciences
Thomas A. Sasani, David G. Ashbrook, Annabel C. Beichman, Lu Lu, Abraham A. Palmer, Robert W. Williams, Jonathan K. Pritchard, Kelley Harris
Summary: This study used BXD mouse lines to identify loci that influence germline mutagenesis. They found that a quantitative trait locus on chromosome 4 affects the accumulation rate of C>A germline mutations in mice, primarily due to the activity of different alleles of the DNA repair gene Mutyh. These alleles are also present in wild populations, indicating that common genetic variation modulates germline mutagenesis.
Editorial Material
Neurosciences
Elizabeth G. Atkinson, Sevim B. Bianchi, Gordon Y. Ye, Jose Jaime Martinez-Magana, Grace E. Tietz, Janitza L. Montalvo-Ortiz, Paola Giusti-Rodriguez, Abraham A. Palmer, Sandra Sanchez-Roige
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Axel Guilbaud, Farzan Ghanegolmohammadi, Yijun Wang, Jiapeng Leng, Alexander Kreymerman, Jacqueline Gamboa Varela, Jessica Garbern, Hannah Elwell, Fang Cao, Elisabeth M. Ricci-Blair, Cui Liang, Seetharamsing Balamkundu, Charles Vidoudez, Michael S. Demott, Kenneth Bedi, Kenneth B. Margulies, David A. Bennett, Abraham A. Palmer, Amanda Barkley-Levenson, Richard T. Lee, Peter C. Dedon
Summary: DNA damage is a major cause of genomic instability in various diseases. Traditional analytical methods provide limited insight into the spectrum of DNA lesions in living organisms. In this study, untargeted chromatography-coupled tandem mass spectrometry (LC-MS/MS) was used to explore the landscape of DNA modifications in rat and human tissues. A total of 114 potential DNA adducts were identified in heart, liver, brain, and kidney tissues of rats, and 111 in human heart and brain tissues using the LC-MS/MS approach. Subsequent targeted analysis revealed species, tissue, age, and sex biases in the DNA adducts. This study demonstrates the potential of adductomics in discovering disease-driving DNA adducts and provides a valuable resource for characterizing new forms of DNA damage and developing biomarkers for aging and disease.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Daniel E. Gustavson, Naomi P. Friedman, Pierre Fontanillas, Sarah L. Elson, Abraham A. Palmer, Sandra Sanchez-Roige
PSYCHOLOGICAL SCIENCE
(2020)