期刊
BEHAVIOR GENETICS
卷 38, 期 5, 页码 503-514出版社
SPRINGER
DOI: 10.1007/s10519-008-9216-1
关键词
behaviour; cognitive disorders; nicotinic receptors; knockout mice; ADHD
资金
- Institut Pasteur
- CNRS
- Letten F. Saugstad Foundation
- Fondation pour la Recherche Medicale
- Association pour la Recherche sur les Nicotianes
Nicotine exerts beneficial effects on various neurological and psychiatric pathologies, yet its effects on cognitive performance remain unclear. Mice lacking the beta2 subunit of the nicotinic receptor (beta 2-/-) show characteristic deficits in executive functions and are suggested as reliable animal models for some specific endophenotypes of human pathologies, notably ADHD. We use beta 2-/- and their controls to investigate the consequences of chronic nicotine exposure on cognitive behaviour. We show that in control mice, this treatment elicits somewhat slight effects, particularly affecting nocturnal activity and self-grooming. By contrast, in beta 2-/- mice, chronic nicotine treatment had restorative effects on exploratory behaviour in the open-field and affected rearing, but did not modify motor functions. We confirmed that beta 2-/- mice exhibit impaired exploratory and social behaviour, and further demonstrated their nocturnal hyperactivity. These data support the proposal that beta 2-/- mice represent a relevant model for cognitive disorders in humans and that nicotine administered chronically at low dose may relieve some of these.
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