Article
Multidisciplinary Sciences
Hiroaki Hiraiwa, Daisuke Kasugai, Masayuki Ozaki, Yukari Goto, Naruhiro Jingushi, Michiko Higashi, Kazuki Nishida, Toru Kondo, Kenji Furusawa, Ryota Morimoto, Takahiro Okumura, Naoyuki Matsuda, Shigeyuki Matsui, Toyoaki Murohara
Summary: This study retrospectively analyzed data from septic shock patients and found that visually-assessed right ventricular dysfunction was associated with in-hospital mortality, lethal arrhythmia, and hemodynamic indicators, suggesting prognostic value in predicting patient outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Mustafa Ozkan, Nurullah Gunay, Elif Funda Sener, Ozgur Karcioglu, Reyhan Tahtasakal, Fatma Dal, Nahide Ekici Gunay, Abdullah Tuncay Demiryurek
Summary: The study revealed significant associations between TNF gene (-308G/A, rs1800629) and NOS3 gene -786T/C (rs2070744) polymorphisms with susceptibility to sepsis in the Turkish population. No significant associations were found with other polymorphisms studied in this research.
JOURNAL OF GENE MEDICINE
(2021)
Review
Medicine, Research & Experimental
Amira Mohamed Taha, Abdelrahman Mohamed Mahmoud, Mohamed M. Ghonaim, Ateeba Kamran, Jehad Feras Alsamhori, Majd M. Albarakat, Abhigan Babu Shrestha, Vikash Jaiswal, Russel J. Reiter
Summary: Septic cardiomyopathy is a complication of sepsis with high mortality rates. Despite extensive research, there is currently no effective pharmacological agent for this condition. Melatonin, with its diverse functions in the body, has emerged as a potential treatment for sepsis-induced cardiomyopathy due to its anti-oxidant, anti-inflammatory, anti-apoptotic, and cardioprotective roles.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Federico Carbone, Luca Liberale, Alberto Preda, Thomas Hellmut Schindler, Fabrizio Montecucco
Summary: The onset of cardiomyopathy in sepsis is a common feature that affects its pathophysiology and clinical care. However, there is a lack of consensus in the definition of sepsis-induced cardiomyopathy, and the wide range of ultrasonographic findings may not fully reflect the understanding of the condition. This review explores the current state of research on sepsis-related cardiomyopathy, highlighting the shortcomings in its definition and discussing the dynamic changes in cardiac performance in response to different hemodynamic clusters. The review also addresses the molecular mechanisms leading to myocardial dysfunction and their similarities to myocardial hibernation.
Article
Pharmacology & Pharmacy
Jiaojiao Wang, Zhiping Liu, Jing Lu, Jiami Zou, Weile Ye, Hong Li, Si Gao, Peiqing Liu
Summary: This study found that SIRT6 regulates endothelial function by modulating the activity of NOS3. SIRT6 activates NOS3 through deacetylation and facilitates its interaction with calmodulin, leading to increased nitric oxide generation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Immunology
Shuang Liu, Wei Chong
Summary: Sepsis is an abnormal systemic inflammatory response to infection that can lead to fatal multiorgan dysfunction syndrome. Sepsic cardiomyopathy is a common complication of sepsis with unclear pathogenesis. Epigenetics and long non-coding RNAs play important roles in regulating septic cardiomyopathy. Mitochondria are important targets in septic cardiomyopathy, and intervention measures to prevent mitochondrial damage are significant for improving prognosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zheng Lin, Hai-Han Liao, Zi-Ying Zhou, Nan Zhang, Wen-Jing Li, Qi-Zhu Tang
Summary: This study investigates the role of RIP2 in lipopolysaccharide-induced septic cardiomyopathy and finds that RIP2 induces an inflammatory response by regulating the TAK1/I kappa B alpha/ NF-kappa B signaling pathway. Inhibition of RIP2 shows potential as a treatment strategy for inhibiting inflammation, alleviating cardiac dysfunction, and improving survival.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Sabrina Schaly, Paromita Islam, Jacqueline L. Boyajian, Rahul Thareja, Ahmed Abosalha, Karan Arora, Dominique Shum-Tim, Satya Prakash
Summary: This study investigates the release of nitric oxide synthase 3 (NOS3) using polyvinyl alcohol-based hydrogels, with a focus on the effects of different compositions on the hydrogel properties. Gelatin is found to protect the viability of the loaded baculovirus, while the addition of chitosan, PEG-8000, and gelatin alters the properties of the hydrogel for different therapeutic applications. Passive absorption of the baculovirus into the hydrogel exhibits the highest loading capacity. Overall, this PVA delivery system demonstrates its potential for high loading and sustained release of baculoviruses, with various clinical applications.
Article
Environmental Sciences
Xuanfeng Zhu, Min Sun, Hongmei Guo, Gan Lu, Jianhua Gu, Lingling Zhang, Licheng Shi, Jia Gao, Dandan Zhang, Wenjun Wang, Jiannan Liu, Xia Wang
Summary: This study demonstrates that verbascoside can exert cardioprotective effects in septic heart injury by inhibiting oxidative stress, inflammation, and apoptosis, as well as promoting mitochondrial biogenesis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Infectious Diseases
Shiqi Guo, Qiang Guo
Summary: Syphilis infection may lead to septic cardiomyopathy, and clinicians should consider Treponema pallidum in cases of septic cardiomyopathy with unknown pathogens. Patients are expected to recover after receiving anti-syphilis treatment.
BMC INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Jose A. Adams, Jose R. Lopez, Arkady Uryash, Marvin A. Sackner
Summary: The study demonstrates that pGz can improve sepsis-induced cardiomyocyte dysfunction and reduce pro-inflammatory response. This could potentially benefit outcomes in patients with sepsis.
Article
Cardiac & Cardiovascular Systems
Hua-Xi Zou, Bai-Quan Qiu, Ze-Yu Zhang, Tie Hu, Li Wan, Ji-Chun Liu, Huang Huang, Song-Qing Lai
Summary: This study analyzed the expression of autophagy-related genes in septic cardiomyopathy (SCM) based on human septic heart transcriptomes, identifying key genes and functional pathways. Furthermore, these key genes were associated with abnormal immune infiltration and showed potential as biomarkers. Finally, the study predicted drugs that could potentially play a protective role in SCM by regulating autophagy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Karolina A. P. Wijnands, Dennis M. Meesters, Benjamin Vandendriessche, Jacob J. Briede, Hans M. H. van Eijk, Peter Brouckaert, Anje Cauwels, Wouter H. Lamers, Martijn Poeze
Summary: Competition between NOS3 and NOS2 for arginine during endotoxemia appears crucial in the derangement of microcirculatory flow. This study found that L-citrulline supplementation enhances de novo arginine synthesis and NO production in mice during endotoxemia, especially in mice with functional NOS3-enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Camylla Vilas Boas Figueiredo, Rayra Pereira Santiago, Caroline Conceicao Guarda, Rodrigo Mota Oliveira, Luciana Magalhaes Fiuza, Setondji Cocou Modeste Alexandre Yahouedehou, Suellen Pinheiro Carvalho, Joelma Santana dos Santos Neres, Antonio Mateus de Jesus Oliveira, Cleverson Alves Fonseca, Valma Maria Lopes Nascimento, Isa Menezes Lyra, Milena Magalhaes Aleluia, Marilda Souza Goncalves
Summary: Priapism, a urologic emergency often associated with sickle cell disease, was found to be linked with alterations in laboratory biomarkers and lower levels of HbF. Patients with sickle cell anemia using hydroxyurea and those who received blood products seemed to have a lower risk of priapism. Multivariate analysis showed that low HbF and NOm were independently associated with priapism.
Article
Cardiac & Cardiovascular Systems
Fabian Muehlberg, Edyta Blaszczyk, Kerstin Will, Stefan Wilczek, Joerg Brederlau, Jeanette Schulz-Menger
Summary: Septic cardiomyopathy is a major complication of septic shock. This pilot study investigated myocardial tissue differentiation in critically ill patients with septic shock using cardiovascular magnetic resonance. The study found that some patients had impaired left ventricular ejection fraction, but this improved during follow-up.
Editorial Material
Cardiac & Cardiovascular Systems
Kerstin Piayda, Verena Veulemans, Malte Kelm, Tobias Zeus
EUROPEAN HEART JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Lili Donner, Laura Mara Toska, Irena Krueger, Sandra Groeniger, Ruben Barroso, Alice Burleigh, Diego Mezzano, Susanne Pfeiler, Malte Kelm, Norbert Gerdes, Steve P. Watson, Yi Sun, Margitta Elvers
Article
Biochemistry & Molecular Biology
Ralf Erkens, Matthias Totzeck, Amanda Brum, Dragos Duse, Hans Erik Botker, Tienush Rassaf, Malte Kelm
Summary: Intact endothelial function is crucial for cardiovascular health, but metabolic alterations in the cardiometabolic continuum hinder the transfer of protective signals in clinical practice. Hyperglycemia, insulin resistance, hyperinsulinemia, and diabetes mellitus affect endothelial signaling and may impact therapeutic strategies. Further research is needed to fully understand the complex interplay between these conditions and endothelial function.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Letter
Respiratory System
Christian Jung, Bernhard Wernly, Jesper Fjolner, Raphael Romano Bruno, David Dudzinski, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sviri Sigal, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Brian Marsh, Finn H. Andersen, Rui Moreno, Maurizio Cecconi, Susannah Leaver, Ariane Boumendil, Dylan W. De Lange, Bertrand Guidet, Hans Flaatten
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Refik Kavsur, Maximilian Spieker, Christos Iliadis, Clemens Metze, Moritz Transier, Vedat Tiyerili, Patrick Horn, Stephan Baldus, Malte Kelm, Georg Nickenig, Ralf Westenfeld, Roman Pfister, Marc Ulrich Becher
Summary: The study evaluated the MIDA score for risk stratification in patients undergoing transcatheter mitral valve repair and found that higher MIDA scores were associated with increased mortality rates and hospitalizations for heart failure. Additionally, higher MIDA scores were also linked to a higher frequency of residual mitral regurgitation after the repair procedure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Lucas Busch, Yvonne Heinen, Manuel Stern, Georg Wolff, Goksen Ozaslan, Konstantina Tzetou, Roberto Sansone, Christian Heiss, Malte Kelm
Summary: Angioplasty of flow-limiting stenoses in patients with peripheral artery disease can lower aortic and brachial blood pressure, especially in patients with more severe lesions and higher baseline systolic blood pressure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Hematology
Rebekka Schneckmann, Tatsiana Suvorava, Christian Hundhausen, Dominik Schuler, Christin Lorenz, Till Freudenberger, Malte Kelm, Jens W. Fischer, Ulrich Flogel, Maria Grandoch
Summary: The study suggests that deficiency of the Has3 gene leads to impaired arteriogenesis and collateral artery growth in limb ischemia, resulting in compromised perfusion recovery. This is associated with diminished endothelial cell function mediated by hyaluronan/CD44 signaling.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Nina Saatmann, Oana-Patricia Zaharia, Klaus Strassburger, Dominik Hans Pesta, Volker Burkart, Julia Szendroedi, Norbert Gerdes, Malte Kelm, Michael Roden
Summary: While endothelial function was similar across all groups, SIRD exhibited the lowest physical fitness. Interestingly, SAID showed the lowest cardiovascular risk within the first year after diabetes diagnosis compared to other diabetes subgroups.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Daniel Oehler, Moritz Benjamin Immohr, Sophia Erbel-Khurtsidze, Hug Aubin, Raphael Romano Bruno, Hans Torulv Holst, Ralf Westenfeld, Patrick Horn, Malte Kelm, Igor Tudorache, Payam Akhyari, Artur Lichtenberg, Udo Boeken
Summary: The cause of death in the donor is associated with outcome and survival after heart transplantation (HTx), with intracerebral bleeding showing the strongest decline in outcome and survival compared to other causes.
Article
Medical Informatics
Christian Jung, Behrooz Mamandipoor, Jesper Fjolner, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sigal Sviri, Peter van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Brian Marsh, Finn H. Andersen, Rui Moreno, Maurizio Cecconi, Susannah Leaver, Dylan W. De Lange, Bertrand Guidet, Hans Flaatten, Venet Osmani
Summary: This study evaluated machine learning-based prognostication models for critically ill elderly COVID-19 patients. The results showed that integrating important clinical events and time-to-event information into the models improved the accuracy of predicting 30-day mortality, compared to models based on admission variables only and conventional ICU prediction models.
JMIR MEDICAL INFORMATICS
(2022)
Article
Cardiac & Cardiovascular Systems
Christian Heiss, Ana Rodriguez-Mateos, Mariam Bapir, Simon S. Skene, Helmut Sies, Malte Kelm
Summary: This study aims to assess Flow-Mediated Dilation (FMD) values in healthy individuals and provides reference values for cardiovascular health measurement. The study found that FMD values are inversely correlated with age, body mass index (BMI), glucose, cholesterol, and blood pressure. Individuals with higher FMD values are younger and have smaller brachial artery diameter, lower blood pressure and cholesterol. Comparisons with coronary artery disease (CAD) patients also showed that FMD values can be used to exclude cardiovascular disease and determine the health status. The meta-analysis results showed that the average FMD in healthy individuals is 6.4%, with a decline trend associated with age.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Tetsu Tanaka, Refik Kavsur, Maximilian Spieker, Christos Iliadis, Clemens Metze, Birthe M. Brachtendorf, Patrick Horn, Christian Zachoval, Atsushi Sugiura, Malte Kelm, Stephan Baldus, Georg Nickenig, Ralf Westenfeld, Roman Pfister, Marc Ulrich Becher
Summary: Giving guideline-directed medical therapy, including beta-blockers, RAS inhibitors, and MRAs, to patients with secondary mitral regurgitation (SMR) undergoing transcatheter edge-to-edge repair (TEER) is associated with a reduced risk of 2-year mortality. This study found that patients with SMR who received triple therapy had a lower incidence of mortality and a higher rate of left ventricular reverse remodelling after TEER.
Letter
Cardiac & Cardiovascular Systems
Elric Zweck, Daniel Scheiber, Heinz-Peter Schultheiss, Oliver Kuss, Malte Kelm, Michael Roden, Ralf Westenfeld, Julia Szendroedi
Editorial Material
Cardiac & Cardiovascular Systems
Tobias Zeus, Artur Lichtenberg, Malte Kelm
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Maximilian Spieker, Malte Kelm, Verena Veulemans
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)