Activation of Liver X receptors in the heart leads to accumulation of intracellular lipids and attenuation of ischemia–reperfusion injury

Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure

(2012) Aalap Chokshi et al.   CIRCULATION

Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation

(2012) Kenta Kuramoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stearoyl-CoA Desaturase-1 (SCD1) Augments Saturated Fatty Acid-Induced Lipid Accumulation and Inhibits Apoptosis in Cardiac Myocytes

(2012) Hiroki Matsui et al.   PLoS One

A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart

(2011) Mark A. Cole et al.   BASIC RESEARCH IN CARDIOLOGY

A Thematic Review Series: Lipid droplet storage and metabolism: from yeast to man: Fig. 1.

(2011) Karen Reue   JOURNAL OF LIPID RESEARCH

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Metabolism, hypoxia and the diabetic heart

(2011) Lisa C. Heather et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Gene therapy with hypoxia-inducible factor 1 alpha in skeletal muscle is cardioprotective in vivo

(2011) Gabor Czibik et al.   LIFE SCIENCES

Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor   in Mouse Liver Reveals Extensive Sharing of Binding Sites

(2011) M. Boergesen et al.   MOLECULAR AND CELLULAR BIOLOGY

Shedding light on the enigma of myocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization

(2010) David N. Brindley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exercise-induced modulation of cardiac lipid content in healthy lean young men

(2010) L. Bilet et al.   BASIC RESEARCH IN CARDIOLOGY

PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation

(2010) Ni-Huiping Son et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells

(2010) M. Susanne Weedon-Fekjaer et al.   JOURNAL OF LIPID RESEARCH

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

LXRβ is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux

(2009) N. P. Hessvik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lipotoxicity in the heart

(2009) Adam R. Wende et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF- B signalling

(2009) S. Wu et al.   CARDIOVASCULAR RESEARCH

Liver X receptor agonist treatment reduced splanchnic ischemia and reperfusion injury

(2009) Concetta Crisafulli et al.   JOURNAL OF LEUKOCYTE BIOLOGY

LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner

(2009) Aurélia Ouvrier et al.   JOURNAL OF LIPID RESEARCH

Effect of intracellular lipid droplets on cytosolic Ca2+and cell death during ischaemia-reperfusion injury in cardiomyocytes

(2009) Ignasi Barba et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Human ADFP Gene Is a Direct Liver-X-Receptor (LXR) Target Gene and Differentially Regulated by Synthetic LXR Ligands

(2009) P. Kotokorpi et al.   MOLECULAR PHARMACOLOGY

Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity

(2008) Andreas Peter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cardioprotection

(2008) Gerd Heusch et al.   CIRCULATION

Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism

(2008) Matthew T Flowers et al.   CURRENT OPINION IN LIPIDOLOGY

Treatment with LXR agonists after focal cerebral ischemia prevents brain damage

(2008) Luigi Sironi et al.   FEBS LETTERS

Pathophysiology of Myocardial Infarction

(2008) Andreas Skyschally et al.   HERZ

Selective Partial Agonism of Liver X Receptor α Is Related to Differential Corepressor Recruitment

(2008) Caroline A. Phelan et al.   MOLECULAR ENDOCRINOLOGY