Article
Pharmacology & Pharmacy
Huiqin Hao, Tao Yuan, Zexin Li, Chenglin Zhang, Jie Liu, Guang Liang, Li Feng, Yong Pan
Summary: This study found that the curcumin analogue C66 has protective effects against acute myocardial infarction by inhibiting tissue inflammation and cardiomyocyte apoptosis, improving cardiac function, and reducing infarct size. C66 also alleviates cardiac hypertrophy and fibrosis. The mechanism involves the inhibition of JNK phosphorylation by C66.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Shu-Juan Zhang, Cong-Xin Huang, Qing-Yan Zhao, He Huang, Jian Zhang
Summary: This study found that M-CSF can increase the expression of M2 macrophage and decrease the levels of M1 macrophage by regulating the P2X7R/NLRP3/IL-1 beta signal pathway, thereby inhibiting inflammation, reducing myocardial hypertrophy, apoptosis, and fibrosis.
Article
Critical Care Medicine
Liang Zhao, Lulu Sun, Xiafei Li, Tian Lu, Yuxue Pan, Pengchong Du
Summary: This study elucidated the cardioprotective mechanism of genipin and demonstrated its potential for treating ischemic heart failure.
Article
Plant Sciences
M. F. Nagoor Meeran, Sheikh Azimullah, Ernest Adeghate, Shreesh Ojha
Summary: This study investigated the cardioprotective effects of Nootkatone (NKT) in rats against isoproterenol-induced myocardial infarction, showing that NKT significantly restored or modulated altered biochemical and molecular parameters in the heart tissues. Histopathological observations confirmed the myocardial restoring effect of NKT, suggesting it as a potential alternative to cardioprotective agents in ischemic heart diseases.
Review
Biochemistry & Molecular Biology
Ewa Szczepanska-Sadowska, Agnieszka Wsol, Agnieszka Cudnoch-Jedrzejewska, Tymoteusz Zera
Summary: Oxytocin and vasopressin play important roles in the brain and peripheral organs, and their secretion is influenced by various factors. Inappropriate regulation may contribute to the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana
Summary: This review summarizes the biological activities and mechanisms of action of Andrographis paniculata and andrographolide in cardiovascular health, showing their protective effects against myocardial injury through various pathways. Further validation in human clinical trials is needed to confirm their therapeutic potential.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Genetics & Heredity
Fang-Qian Liang, Jing-Yuan Gao, Ji-Wei Liu
Summary: The study revealed that CXCL16 is increased in myocardial infarction and is directly targeted by miR-545, exacerbating MI damage by mediating inflammatory responses. This provides potential therapeutic targets for MI therapy.
Article
Medicine, Research & Experimental
Donghai Liu, Chenhui Qiao, Hong Luo
Summary: The study elucidated the role of miR-1278 in myocardial infarction (MI) development, showing that its overexpression protects against cell death by modulating IL-22 and CXCL14 expression.
Review
Cardiac & Cardiovascular Systems
Alessandra Maria Lodrini, Marie-Jose Goumans
Summary: Despite the advancement in interventional coronary reperfusion strategies, mortality from acute myocardial infarction remains high. MI leads to adverse remodelling in the affected myocardium, with cellular phenotypes like senescence, inflammation, and dedifferentiation playing key roles in the pathophysiology of the infarcted heart. Enhancing electric coupling between cardiomyocytes, eliminating senescent cells, and upregulating cellular processes like autophagy could potentially improve cardiac contractility post-MI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Chaorui Xu, Zhuowen Jia, Xuefei Cao, Sha Wang, Jipeng Wang, Liping An
Summary: This study demonstrates the potential role of circ_0007059 in the pathogenesis of myocardial infarction (MI). It is upregulated in response to oxidative stress and downregulates the expression of miR-378 and miR-383, resulting in reduced apoptosis and inflammation in cardiomyocytes. Moreover, lentiviral shRNA-circ_0007059 administration in mice with MI reduces infarct size and promotes cardiac activity.
Article
Cell Biology
Lijia Zhang, Lifang Lv, Nan Zheng, Ruotong Li, Rui Yang, Tianyu Li, Yingnan Li, Yingqi Liu, Hongwei Luo, Xuelian Li, Yuhong Zhou, Hongli Shan, Bing Bai, Haihai Liang
Summary: Sox4 plays a role in promoting cardiomyocyte apoptosis during myocardial infarction by regulating Bim expression, and silencing Sox4 can attenuate cardiomyocyte apoptosis, suggesting it as a potential therapeutic target for MI.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Peng Yu, Shuai Song, Xiaokai Zhang, Shujun Cui, Gang Wei, Zihang Huang, Linqi Zeng, Ting Ni, Aijun Sun
Summary: This study revealed the regulatory mechanism of APA in post-MI HF and identified the potential therapeutic effect of the APA-regulated gene AVEN in treating HF.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Endocrinology & Metabolism
Juin Maity, Tiyasa Dey, Adrita Banerjee, Aindrila Chattopadhyay, Asish R. Das, Debasish Bandyopadhyay
Summary: In recent years, the increase in obesity-related diseases and obesity-induced cardiovascular diseases has become a major health issue. The destruction of cardiac tissues caused by obesity starts with the imbalance in lipoprotein metabolism, leading to cholesterol deposition and plaque formation on the arterial wall, followed by cardiac spasms and infarction. Obesity also disrupts metabolism and generates free radicals, triggering inflammation and damaging the myocardium. Melatonin, as an effective antioxidant and anti-inflammatory substance, can inhibit these damages and protect cardiovascular health.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Nada Joe Melhem, Mouna Chajadine, Ingrid Gomez, Kiave-Yune Howangyin, Marion Bouvet, Camille Knosp, Yanyi Sun, Marie Rouanet, Ludivine Laurans, Olivier Cazorla, Mathilde Lemitre, Jose Vilar, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Jean-Sebastien Hulot, Jacques Callebert, Jean-Marie Launay, Jeremy Fauconnier, Jean-Sebastien Silvestre, Soraya Taleb
Summary: The study suggests that IDO could be a potential therapeutic target in acute myocardial infarction, as its deficiency limits cardiac injury and dysfunction after MI, with endothelial cell-specific deletion of IDO showing improvement in cardiac function and reduction in adverse ventricular remodeling.
Article
Pharmacology & Pharmacy
Mahmoud M. Farag, Asmaa A. Khalifa, Wessam F. Elhadidy, Radwa M. Rashad
Summary: The study demonstrated dose-dependent protective effects of thymoquinone (TQ) against isoproterenol (ISO)-induced myocardial injury in rats, showing reduced infarct size, inhibition of oxidative stress and inflammation, decreased levels of serum cardiac markers, and enhanced autophagy. TQ also increased myocardial reduced glutathione baseline level, acting as an indirect antioxidant, and reduced markers of oxidative stress, inflammation, fibrosis, and apoptosis. These findings suggest that TQ may serve as a promising prophylactic cardioprotective therapy for patients at risk of myocardial injury.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Eric Plante, Ahmed Menaouar, Bogdan A. Danalache, Denis Yip, Tom L. Broderick, Jean-Louis Chiasson, Marek Jankowski, Jolanta Gutkowska
Meeting Abstract
Peripheral Vascular Disease
M. Jankowski, E. Plante, A. Menaouar, J. L. Chiasson, J. Gutkowska
JOURNAL OF HYPERTENSION
(2015)
Article
Cell Biology
Araceli Gonzalez-Reyes, Ahmed Menaouar, Denis Yip, Bogdan Danalache, Eric Plante, Nicolas Noiseux, Jolanta Gutkowska, Marek Jankowski
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2015)
Review
Endocrinology & Metabolism
Marek Jankowski, Tom L. Broderick, Jolanta Gutkowska
BMC ENDOCRINE DISORDERS
(2016)
Article
Endocrinology & Metabolism
Tom L. Broderick, Marek Jankowski, Jolanta Gutkowska
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2017)
Review
Biology
J. Gutkowska, M. Jankowski, J. Antunes-Rodrigues
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2014)
Article
Cardiac & Cardiovascular Systems
Ahmed Menaouar, Maria Florian, Donghao Wang, Bogdan Danalache, Marek Jankowski, Jolanta Gutkowska
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2014)
Article
Endocrinology & Metabolism
Bogdan A. Danalache, Calvin Yu, Jolanta Gutkowska, Marek Jankowski
JOURNAL OF ENDOCRINOLOGY
(2014)
Article
Cardiac & Cardiovascular Systems
Marek Jankowski, Aleksandra Niedzielska, Michal Brzezinski, Jozef Drabik
PEDIATRIC CARDIOLOGY
(2015)
Article
Endocrinology & Metabolism
Tom L. Broderick, Donghao Wang, Marek Jankowski, Jolanta Gutkowska
REGULATORY PEPTIDES
(2014)
Article
Endocrinology & Metabolism
Tom L. Broderick, Jacqueline M. Sennott, Jolanta Gutkowska, Marek Jankowski
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2019)
Article
Multidisciplinary Sciences
Marek Jankowski, Bogdan A. Danalache, Eric Plante, Ahmed Menaouar, Maria Florian, Ju Jing Tan, Ryszard Grygorczyk, Tom L. Broderick, Jolanta Gutkowska
Meeting Abstract
Respiratory System
Maciej Gawronski, Piotr Kopinski, Marek Jankowski, Arkadiusz Goede, Adam Szpechcinski, Joanna Chorostowska
EUROPEAN RESPIRATORY JOURNAL
(2015)
Meeting Abstract
Endocrinology & Metabolism
Denis Yip, Eric Plante, Bogdan Danalache, Marek Jankowski, Jolanta Gutkowska, Ahmed Menaouar
Meeting Abstract
Endocrinology & Metabolism
Eric Plante, Ahmed Menaouar, Bogdan A. Danalache, Marek Jankowski, Jolanta Gutkowska