Article
Biochemistry & Molecular Biology
Marisa Esteves-Monteiro, Daniela Menezes-Pinto, Mariana Ferreira-Duarte, Patricia Dias-Pereira, Manuela Morato, Margarida Duarte-Araujo
Summary: Diabetes mellitus is associated with gastrointestinal complications, and a rat model of diabetes showed structural remodelling of the gut wall and decreased contractile response to AngII.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Anand Kumar, Priyanka Prajapati, Vinit Raj, Seong-Cheol Kim, Vikas Mishra, Chaitany Jayprakash Raorane, Ritu Raj, Dinesh Kumar, Sapana Kushwaha
Summary: This study found that salbutamol can alleviate muscle atrophy and has antioxidant and anti-inflammatory effects in streptozotocin-induced diabetic rats.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Tim Gerwinn, Souzan Salemi, Larissa J. Schori, Dafni Planta, Daniel Eberli, Maya Horst
Summary: This study suggests that bladder detrusor smooth muscle microtissues derived from pediatric ESLUTD patients exhibit improved contractile potential and extracellular matrix composition, which may make them suitable as a cell source for autologous bladder tissue engineering.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
Navroop Johal, Kevin X. Cao, Boyu Xie, Michael Millar, Reena Davda, Aamir Ahmed, Anthony J. Kanai, Dan N. Wood, Rita Jabr, Christopher H. Fry
Summary: The study revealed impaired contractility and increased stiffness of bladder wall muscle in patients with bladder function disorders, associated with fibrosis. Research on neurogenic lower urinary tract dysfunction patients showed reduced contractility, increased stiffness, and increased connective tissue content in detrusor muscle.
Article
Biochemistry & Molecular Biology
Naoko Mochida, Yoko Matsumura, Masahiro Kitabatake, Toshihiro Ito, Shin-ichi Kayano, Hiroe Kikuzaki
Summary: This study investigated the potential antioxidant activity of non-extractable fractions of dried persimmon (NEP) against oxidative stress in diabetic rats. The administration of NEP increased body weight and improved the antioxidant defense system in the liver tissues of diabetic rats. NEP also attenuated muscle fiber atrophy induced by hyperglycemia.
Article
Medicine, Research & Experimental
Wan Seok Kang, Woo Kwon Jung, Su-Bin Park, Hyung Rae Kim, Junghyun Kim
Summary: The DPP4 inhibitor gemigliptin demonstrates protective effects against salivary dysfunction in diabetes by mediating antioxidant, anti-apoptotic, and salivary secretion mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Shaimaa Maher, Mekki Bayachou, Pingfu Fu, Adonis Hijaz, Guiming Liu
Summary: Recent studies indicate that smooth muscle contraction may involve mechanisms beyond MLC phosphorylation-induced actomyosin crossbridge cycling. This study explores the involvement of focal adhesion kinase (FAK) activation in mouse detrusor muscle contraction.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Physical
Alaa A. A. Aljabali, Bahaa Al-Trad, Lina Al Gazo, Ghada Alomari, Mazhar Al Zoubi, Walhan Alshaer, Khalid Al-Batayneh, Bahja Kanan, Kaushik Pal, Murtaza M. Tambuwala
Summary: The study investigated the effects of gold nanoparticles (AuNPs) on an animal model of diabetic cardiomyopathy (DCM). The results indicated that AuNPs reduced the pathological conditions associated with DCM, suggesting a therapeutic potential for AuNPs in the treatment of early DCM. Further research is needed to explore the mechanisms by which AuNPs may prevent the development of DCM.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Pharmacology & Pharmacy
Florian Dilasser, Marc Rio, Lindsay Rose, Angela Tesse, Christophe Guignabert, Gervaise Loirand, Vincent Sauzeau
Summary: This study demonstrates the protective effect of SMC Rac1 deletion against hypoxic PH. Rac1 activity in PASMCs plays a causal role in PH by promoting ROS-dependent PA remodeling and endothelial dysfunction induced by chronic hypoxia.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Food Science & Technology
Maojun Yao, Hui Teng, Qiyan Lv, Huifang Gao, Tengming Guo, Yiwen Lin, Sihai Gao, Meihu Ma, Lei Chen
Summary: DHM exhibits significant anti-hyperglycemic and anti-hyperinsulinemic effects, possibly through the regulation of the AMPK/Akt/GSK-3 beta signaling pathway.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Biochemistry & Molecular Biology
Dina Mostafa Mohammed, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Mohamed El-Sherbiny, Wael A. Mahdi, Sultan Alshehri, Hasnaa A. Ebrahim, Amr Farouk
Summary: This study aims to examine the potential impact of key flavors and their nanocapsules on health and diseases, such as type 2 diabetes mellitus. The results showed that these flavors and nanocapsules have a potential anti-hyperglycemic effect and improved the rat health without any health drawbacks.
Article
Biochemistry & Molecular Biology
Dina Mostafa Mohammed, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Mohamed El-Sherbiny, Wael A. Mahdi, Sultan Alshehri, Hasnaa A. Ebrahim, Amr Farouk
Summary: This study aims to examine the potential impact of key flavors and their nanocapsules on health and diseases, such as type 2 diabetes mellitus (T2DM). The findings suggest that these flavors and nanocapsules may have a beneficial effect on T2DM without any health drawbacks.
Article
Biochemistry & Molecular Biology
Amir Taldaev, Anastasiya D. Savina, Vera V. Olicheva, Sergey V. Ivanov, Roman P. Terekhov, Igor R. Ilyasov, Anastasiya K. Zhevlakova, Irina A. Selivanova
Summary: Oxidative stress is a key factor in the development of diabetes and its complications. In this study, the protective properties of taxifolin spheroidal form (TS) were examined in a rat model of diabetes. Treatment with TS for 4 weeks resulted in a significant decrease in fasting blood glucose levels and feed intake in diabetic rats. TS also showed a protective effect on the pancreas and liver against the cytotoxic action of streptozotocin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Nurdiana Samsulrizal, Yong-Meng Goh, Hafandi Ahmad, Sulaiman Md Dom, Nur Syimal'ain Azmi, Noor Syaffinaz NoorMohamad Zin, Mahdi Ebrahimi
Summary: Ficus deltoidea can significantly increase bone mineral density, promote osteogenesis, and inhibit bone oxidative stress, potentially serving as a therapy for diabetic osteoporosis.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rui Zhang, Xiaojun Zhou, Qiqi Sheng, Qian Zhang, Tianyue Xie, Chunmei Xu, Zhiwei Zou, Jianjun Dong, Lin Liao
Summary: The study showed that Gliquidone can lower fasting blood glucose and increase insulin sensitivity in diabetic Sur1-- rats, mainly by increasing hepatic glycogen storage and decreasing gluconeogenesis. However, its effects were still weaker compared to metformin.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Urology & Nephrology
H. Akdag, N. Murat, S. Evcim, A. Esen, S. Gidener
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2016)
Article
Urology & Nephrology
Nergiz Murat, Peyda Korhan, Onur Kizer, Sinem Evcim, Aykut Kefi, Omer Demir, Sedef Gidener, Nese Atabey, Ahmet Adil Esen
JOURNAL OF SEXUAL MEDICINE
(2016)
Article
Medicine, General & Internal
Ozan Bozkurt, Aykut Kefi, Omer Demir, Nergis Murat, Sedef Gidener, Ahmet Adil Esen
TURKISH JOURNAL OF MEDICAL SCIENCES
(2016)
Article
Urology & Nephrology
N. Durmus, A. Toylu, S. Evcim, B. C. Soner, O. Demir, E. Kahraman, T. Demir, B. Irer, S. Gidener, N. Atabey, A. Esen
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2017)
Article
Pharmacology & Pharmacy
Mesut Arici, Salih Kavukcu, Sakine Tuncay Tanriverdi, Aylin Arici, Sedef Gidener, Ayse Gelal, Ozgen Ozer
CURRENT DRUG DELIVERY
(2017)
Article
Andrology
O. Cinar, N. Durmus, G. Aslan, O. Demir, A. S. Evcim, S. Gidener, A. A. Esen
Article
Pharmacology & Pharmacy
Ayse Gelal, Mukaddes Gumustekin, M. Aylin Arici, Sedef Gidener
INDIAN JOURNAL OF PHARMACOLOGY
(2013)
Article
Pediatrics
Osman Z. Karakus, Oguz Ates, Nergis Murat, Gulce Hakguder, Mustafa Olguner, Bora Solmaz, Erdener Ozer, Sedef Gidener, Feza M. Akgur
JOURNAL OF PEDIATRIC SURGERY
(2013)
Article
Urology & Nephrology
Asif Cahangirov, Ahmet Cihan, Nergis Murat, Omer Demir, Guven Aslan, Sedef Gidener, Ahmet Adil Sesen
JOURNAL OF SEXUAL MEDICINE
(2011)
Article
Medicine, Research & Experimental
Burc Aydin, Nil Hocaoglu, Sedef Gidener
MEDICAL HYPOTHESES
(2012)
Article
Gastroenterology & Hepatology
Yahya T. Orhan, Cem Karagozlu, Sulen Sarioglu, Osman Yilmaz, Nergiz Murat, Sedef Gidener
TURKISH JOURNAL OF GASTROENTEROLOGY
(2012)
Article
Andrology
Erkan Kara, Erkan Kahraman, Ezgi Dayar, Gunay Yetik Anacak, Omer Demir, Sedef Gidener, Nese Atabey, Nergiz Durmus
Article
Andrology
E. Dayar, E. Kara, G. Yetik-Anacak, N. Hocaoglu, O. Bozkurt, S. Gidener, N. Durmus
Article
Medicine, General & Internal
B. C. Soner, N. Murat, H. Guven, S. Gidener
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2013)