Article
Immunology
Cheng Peng, Guangping Tu, Li Yu, Peng Wu, Xianlin Zhang, Zheng Li, Zhiqiang Li, Xiao Yu
Summary: This study investigates the macrophage profile and regulatory mechanisms in mouse pancreatitis, as well as its correlation with human chronic pancreatitis. The results show that the expression of TNF-alpha and IL-6 increases over time, while pancreatic fibrosis peaks at day 21. M2 macrophages also peak at day 21.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Santhi Swaroop Vege, Suresh T. Chari
Summary: Chronic pancreatitis is often associated with alcohol use, smoking, or genetic risk factors. Common symptoms include recurrent abdominal pain or pancreatitis, and characteristic imaging findings include pancreatic stones, dilated ducts, and atrophy. Complications include pseudocysts, biliary strictures, exocrine and endocrine pancreatic insufficiency, bone loss, and pancreatic cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Agnieszka Mucha, Malgorzata Zaczek, Michal Kralisz, Ewa Gruszewska, Bogdan Cylwik, Anatol Panasiuk, Lech Chrostek
Summary: Pancreatitis affects the serum profile of transferrin isoforms, with a decrease in pentasialotransferrin and an increase in tetrasialotransferrin. There are no significant changes in transferrin isoforms between acute and chronic pancreatitis or between different forms of the disease. Alcoholic etiology of pancreatitis is associated with higher levels of bile acids and gamma-glutamyltransferase. These findings suggest that the serum profile of transferrin isoforms plays a role in the pathogenesis of pancreatitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Sathasivam Sureshkumar, Agrawal Omang, Amaranathan Anandhi, B. S. Rajesh, K. M. Abdulbasith, Chellappa Vijayakumar, Chinnakali Palanivel, Mohan Pazhanivel, Vikram Kate
Summary: The combination of pregabalin and antioxidant therapy has been shown to significantly reduce pain intensity, decrease the requirement for non-opioid analgesics, and reduce the number of hospital admissions in patients with chronic pancreatitis. Overall patient satisfaction is also significantly improved with this treatment approach.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Surgery
Arkadeep Dhali, Sukanta Ray, Avik Sarkar, Sujan Khamrui, Somak Das, Tuhin Subhra Mandal, Dijendra Nath Biswas, Gopal Krishna Dhali
Summary: This study retrospectively analyzed patients with bleeding pseudoaneurysms in the setting of chronic pancreatitis, showing that both embolization and surgery are important in its management, with the choice of procedure depending on local availability and feasibility of a particular technique. Intraoperative blood transfusion, surgical time, and blood loss were important indicators in the management of PSA.
UPDATES IN SURGERY
(2022)
Article
Medicine, General & Internal
Daniel Selin, Bei Yang, Mats Lindblad, Urban Arnelo, Magnus Nilsson, Omid Sadr-Azodi, John Maret-Ouda
Summary: The Swedish Pancreatitis Cohort (SwePan) was created to study long-term outcomes and risk factors for acute pancreatitis. It includes all cases of acute pancreatitis in Sweden from 1990 to 2019, along with matched pancreatitis-free individuals. The dataset provides comprehensive information collected from multiple registries.
Review
Physiology
Yasunobu Yamashita, Reiko Ashida, Masayuki Kitano
Summary: Chronic pancreatitis is a condition characterized by long-standing inflammation of the pancreas, leading to irreversible and progressive fibrosis. Various imaging modalities, including magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP), computed tomography (CT), and endoscopic ultrasonography (EUS), are used to diagnose and assess chronic pancreatitis. Among these modalities, EUS is considered the most reliable and efficient diagnostic tool for pancreatic diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hao Zhang, Yinghao Meng, Qi Li, Jieyu Yu, Fang Liu, Xu Fang, Jing Li, Xiaochen Feng, Jian Zhou, Mengmeng Zhu, Na Li, Jianping Lu, Chengwei Shao, Yun Bian
Summary: This study developed and validated CT and radiomics nomograms to differentiate mass-forming chronic pancreatitis (MFCP) from pancreatic ductal adenocarcinoma (PDAC). The nomograms showed good differentiation ability in patients with chronic pancreatitis and have the potential to refine the management of pancreatic masses in these patients.
EUROPEAN RADIOLOGY
(2022)
Article
Surgery
Kai Bachmann, Nathaniel Melling, Rainer Groteluschen, Anne Fleischauer, Matthias Reeh, Tarik Ghadban, Max Bockhorn, Jakob R. Izbicki
Summary: This study analyzed clinicopathologic findings and outcomes of 1146 patients undergoing surgical treatment for chronic pancreatitis, identifying factors like the presence of inflammatory mass, dilated main pancreatic duct, severe calcifications, severe fibrosis, and ethanol-induced disease as strong prognostic factors for pain relief. The Chronic Pancreatitis Pain Relief Score was proposed as a predictive tool for identifying patients who will benefit most from surgery, with an overall pain relief rate of 79.8%.
Article
Acoustics
Francesca d'Aversa, Maria elena Ainora, Irene Mignini, Antonio Liguori, Matteo Garcovich, Danilo Pagliari, Fabia Attili, Alberto Larghi, Gianenrico Rizzatti, Laura Riccardi, Lorenzo zileri Dal Verme, Maurizio Pompili, Antonio Gasbarrini, Maria Assunta Zocco Cemad
Summary: The Gemelli Ultrasound Chronic Pancreatitis (USCP) score plays an important role in the diagnosis of chronic pancreatitis (CP) and can be used as a non-invasive tool. It is correlated with pancreatic exocrine insufficiency and shows agreement with standard imaging techniques.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Williamson B. Strum, Clement Richard Boland
Summary: This article reviews articles published between 2019-2022 from international sources and identifies four crucial new findings in acute pancreatitis and chronic pancreatitis. These findings include new genetic pathogenic mutations, a new serum diagnostic marker for AP, explanations of the impact of monocytes/macrophages, and authoritative recommendations for medical treatment of chronic pain. These advances provide opportunities to enhance outcomes, alter the natural history, and envision the future of these diseases.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Miroslav Vujasinovic, Ana Dugic, Amar Nouri, Torkel B. Brismar, Francisco Baldaque-Silva, Ebba Asplund, Wiktor Rutkowski, Poya Ghorbani, Ernesto Sparrelid, Hannes Hagstrom, J-Matthias Lohr
Summary: The study found that approximately 8.4% of patients with chronic pancreatitis developed vascular complications, mainly splanchnic venous thrombosis. Splenic vein thrombosis was the most common, while arterial pseudoaneurysm was less common. Most patients were asymptomatic with no variceal bleeding, possibly explained by well-developed collateral circulation and strict study inclusion criteria.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Mengqi Zhao, Mengyan Cui, Qiaoli Jiang, Jingjing Wang, Yingying Lu
Summary: This study aims to examine the alterations in the microbial composition of the pancreas and ileum in the context of experimental acute pancreatitis, as well as explore the potential interplay between these two regions. The results showed microbial structural segregation in the pancreas and ileum between the acute pancreatitis and control groups. The study also found that caerulein and L-arginine differentially disturbed the pancreatic and ileal microbiota when inducing acute pancreatitis.
Article
Medical Laboratory Technology
Guenter Kloeppel, Giuseppe Zamboni
Summary: This passage presents the progress made in the diagnosis and recognition of pancreatitis, necroinflammatory and fibroinflammatory processes. It focuses on the pathology and pathogenesis of alcohol-associated pancreatitis, including paraduodenal pancreatitis. The article also discusses the histopathological characteristics and imaging findings associated with these conditions.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Sheng-Yu Zhang, Yun-Lu Feng, Long Zou, Xi Wu, Tao Guo, Qing-Wei Jiang, Qiang Wang, Ya-Min Lai, Shou-Jiang Tang, Ai-Ming Yang
Summary: This study demonstrated the differences in EUS features of newly diagnosed AIP, as well as the disparities in typical AIP and CP features between diffuse and focal AIP. The CP change level was found to be relatively limited in newly diagnosed AIP cases in both groups.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Marco B. Mahdi, Emily Steinkohl, Vikesh K. Singh, Asbjorn M. Drewes, Jens B. Frokjaer, Soren S. Olesen
Summary: In medically managed patients with chronic pancreatitis, those with large duct CP have a higher prevalence of diabetes and exocrine insufficiency compared to small duct CP. There is also an increased risk of new-onset exocrine insufficiency and higher rates of pancreatic atrophy in patients with large duct CP.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Mikael Parhiala, Anne Waage, Povilas Ignatavicus, Jakob L. Poulsen, Engjom Trond, Georg Dimcevski, Ingrid Nordaas, Amer Hadi, Evangelos Kalaitzakis, Asbjorn M. Drewes, Camilla Nojgaard, Johanna Laukkarinen
Summary: This study aimed to determine the surgical treatment strategies for chronic pancreatitis (CP) in the Scandinavian and Baltic countries. The results showed that only 7% of CP patients underwent pancreatic surgery, with 51% of them undergoing surgery for chronic pain. After surgery, 47% of the patients were pain-free and half of the patients reported no pain.
Article
Medicine, Research & Experimental
Cornelis Jan van Dam, Monique van Velzen, Cornelis Kramers, Arnt Schellekens, Erik Olofsen, Marieke Niesters, Albert Dahan
Summary: This study aims to investigate whether self-titration of oxycodone and cannabis can reduce side effects in chronic pain patients with fibromyalgia.
Article
Substance Abuse
Ulrik Becker, Amalie Timmermann, Ola Ekholm, Morten Gronbaek, Asbjorn Mohr Drewes, Srdan Novovic, Camilla Nojgaard, Soren Schou Olesen, Janne Schurmann Tolstrup
Summary: This study analyzed the effects of drinking pattern and type of alcohol on the risk of acute and chronic pancreatitis. The results showed that increased alcohol intake was associated with increased development of pancreatitis. Frequent binge drinking and long-term drinking (daily drinking) were associated with the development of pancreatitis. The intake of large amounts of spirits and beer was associated with the development of acute and chronic pancreatitis, while the consumption of wine was not associated with the development of pancreatitis.
ALCOHOL AND ALCOHOLISM
(2023)
Article
Pharmacology & Pharmacy
Tina Okdahl, Esben Bolvig Mark, Rasmus Bach Nedergaard, Cecilie Siggaard Knoph, Mathias Ellgaard Cook, Klaus Krogh, Asbjorn Mohr Drewes
Summary: Opium tincture, traditionally used for chronic diarrhea, has been found to decrease bowel movements and increase stool consistency without causing sedation. This controlled trial demonstrates that opium tincture has anti-propulsive properties in the healthy gut, making it a relevant and safe treatment option for chronic diarrhea.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Review
Medicine, General & Internal
Christoffer S. Graven-Nielsen, Cecilie S. Knoph, Tina Okdahl, Katrine L. Hoyer, Klaus Krogh, Per M. Hellstroem, Asbjorn M. Drewes
Summary: In patients with chronic idiopathic diarrhea resistant to standard treatment, opioids are often used as rescue therapy. This systematic review investigated the effects of opioid agonists on gut function in chronic diarrhea. The review found that opioid receptor agonists such as loperamide, asimadoline, casokefamide, and codeine reduced stool frequency and increased transit time compared with placebo, while loperamide and diphenoxylate significantly improved stool consistency. However, the evidence from clinical trials is limited and more research is needed to establish standardized endpoints and larger prospective studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Marieke Hellinga, Marijke Hyke Algera, Rutger van der Schrier, Elise Sarton, Monique van Velzen, Albert Dahan, Erik Olofsen, Marieke Niesters
Summary: The respiratory parameter _V(E)55 from the hypercapnic ventilatory response (HCVR) is the most sensitive biomarker of opioid-induced respiratory depression (OIRD). This finding can be used for standardized comparison of opioids in assessing their safety.
Review
Anesthesiology
Anne-Marie Wegeberg, Trine Hyttel Sejersgaard-Jacobsen, Christina Brock, Asbjorn Mohr Drewes
Summary: Pain is a major clinical challenge, and understanding its pathophysiology is critical for optimal management. This systematic review investigates the ability of electrocardiographic-derived measures to predict pain, and finds that increased parasympathetic activity can predict pain reduction in different types of pain.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Gastroenterology & Hepatology
Mathias Ellgaard Cook, Niels Henrik Bruun, Line Davidsen, Asbjorn Mohr Drewes, Soren Schou Olesen
Summary: Understanding the nature of inflammatory pancreatic diseases is crucial for healthcare planning. This study found an increased risk of chronic pancreatitis and pancreatic cancer in patients with a history of acute pancreatitis, with most transitioning directly from a healthy state.
Article
Gastroenterology & Hepatology
Morten Hasselstrom Jensen, Simon Lebech Cichosz, Ole Hejlesen, Stine Dam Henriksen, Asbjorn Mohr Drewes, Soren Schou Olesen
Summary: This nationwide population-based retrospective cohort study examined the 3-year cumulative incidence of pancreatic ductal adenocarcinoma (PDAC) in people 50 years and older with new onset diabetes (NOD). The study found that the risk of PDAC among this population was approximately 0.6%. People with pancreatic cancer-related diabetes (PCRD) had distinct demographic and clinical profiles compared to those with type 2 diabetes (T2D), including different trajectories of plasma HbA1c and triglyceride levels.
Article
Gastroenterology & Hepatology
Mikael Parhiala, Camilla Nojgaard, Andreas Bartholdy, Anne Waage, Povilas Ignatavicius, Trond Engjom, Georg Dimcevski, Ingrid Kvale Nordaas, Evangelos Kalaitzakis, Asbjorn M. Drewes, Amer Hadi, Soren S. Olesen, Jakob L. Poulsen, Johanna Laukkarinen, Scandinavian Baltic Pancreatic Club
Summary: This study aimed to determine the frequency of endoscopic procedures (EP) in chronic pancreatitis (CP) patients and analyze their pain and quality of life (QoL) after the procedures. The study found that 20% of CP patients underwent EP, and these patients had higher QoL scores and improved symptoms. Patients who had pancreatic stenting had similar pain patterns to the reference population.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Clinical Neurology
Cecilie Siggaard Knoph, Rasmus Bach Nedergaard, Soren Schou Olesen, Louise Kuhlmann, Asbjorn Mohr Drewes
Summary: Abdominal pain is common in patients with chronic pancreatitis and is difficult to manage due to altered pain processing in the central nervous system. We hypothesized that patients with painful chronic pancreatitis have generalized hyperalgesia and increased central neuronal excitability. Our study confirmed somatic hyperalgesia in these patients, highlighting the importance of targeting central mechanisms for management.
JOURNAL OF PAIN RESEARCH
(2023)
Meeting Abstract
Anesthesiology
Konrad Meissner, Albert Dahan, Erik Olofsen, Jane Blood, Johannes Wieditz, Evan Kharasch
ANESTHESIA AND ANALGESIA
(2023)
Meeting Abstract
Anesthesiology
Konrad Meissner, Erik Olofsen, Albert Dahan, Johannes Wieditz, Evan Kharasch
ANESTHESIA AND ANALGESIA
(2023)
