Article
Clinical Neurology
David Matuskey, Jean-Dominique Gallezot, Nabeel Nabulsi, Shannan Henry, Kristen Torres, Mark Dias, Gustavo A. Angarita, Yiyun Huang, Susan E. Shoaf, Richard E. Carson, Shailly Mehrotra
Summary: This study investigated the occupancy time course of NET, DAT, and SERT and their relationship to centanafadine plasma concentrations. The results showed high occupancy at NET and moderate occupancy at DAT and SERT following 400 mg total daily doses of centanafadine.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Isabel Ellerbrock, Angelica Sandstrom, Jeanette Tour, Silvia Fanton, Diana Kadetoff, Martin Schalling, Karin B. Jensen, Rouslan Sitnikov, Eva Kosek
Summary: This study found interactions between serotonin-relevant genes in affective characteristics, with high serotonergic signalling being more favorable for mood across groups. Additionally, an association between the serotonergic system and thalamic GABA concentrations was observed, with individuals possessing genetically inferred high serotonergic signalling exhibiting the highest GABA concentrations.
Review
Neurosciences
George M. Anderson, Isabella Bruno-Pacella
Summary: This article assesses the bioeffect of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) and compares them using neuroimaging and in vitro measurements. The study finds that these drugs typically result in a 70-90% reduction in platelet serotonin (5-HT) content. The bioeffect is similar among different types of SSRIs and SNRIs and is consistent with other assessment methods.
PSYCHOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Jeong-Hee Kim, Hang-Keun Kim, Sang-Wha Lee, Young-Don Son, Jong-Hoon Kim
Summary: This study investigated the potential relationship between human character traits (self-directedness, cooperativeness, and self-transcendence) and serotonergic activity, specifically the availability of serotonin transporter (5-HTT) in certain brain regions. The results showed significant positive correlations between self-directedness and 5-HTT availability in specific brain regions, suggesting that a goal-oriented, self-confident, and resourceful character may be related to higher serotonergic neurotransmission. In addition, cooperativeness was significantly negatively correlated with 5-HTT availability in the median raphe nucleus, and self-transcendence was significantly negatively correlated with 5-HTT availability in the right MTG and ITG.
Article
Biochemistry & Molecular Biology
Ji-Hyeon Jeon, Jin-Hyang Park, So Yeon Jeon, Minyeong Pang, Min-Koo Choi, Im-Sook Song
Summary: This study investigates the interactions between red ginseng extract (RGE) and lactic acid bacteria (LAB) in terms of in vitro and in vivo deglycosylation metabolism and the pharmacokinetics of ginsenosides. The results show that the co-administration of RGE and LAB significantly increases the plasma concentrations of deglycosylated ginsenosides and facilitates the deglycosylation metabolism of ginsenosides.
Article
Neurosciences
Gael Villanueva-Charbonneau, Stephane Potvin, Serge Marchand, Alexander McIntyre, Diane McIntosh, Alain Bissonnette, Alain Gendron, Charles-edouard Giguere, Marie-eve Koue, Edouard Kouassi
Summary: This study found that mRNA expression of serotonin transporter (SERT) on the surface of peripheral blood mononuclear cells (PBMCs) was significantly reduced in subjects with major depression disorder (MDD), but not in those with fibromyalgia (FM) or FM + MDD. Although drug treatment improved symptoms, it had no significant effect on SERT mRNA expression.
Article
Pharmacology & Pharmacy
Lucia Caffino, Francesca Mottarlini, Giorgia Targa, Michel M. M. Verheij, Judith Homberg, Fabio Fumagalli
Summary: The study found that the deletion of serotonin transporter (SERT) may sensitize the glutamatergic synapses of the nucleus accumbens core to long-term but not short-term intake of cocaine.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Sophia Armand, Brice Ozenne, Nanna Svart, Vibe G. Frokjaer, Gitte M. Knudsen, Patrick M. Fisher, Dea S. Stenbaek
Summary: Cognitive affective biases refer to the preference for processing negative or positive information. This study investigated the association between 5-HTT levels, measured using positron emission tomography, and affective biases in healthy individuals. The findings suggest that higher 5-HTT levels are associated with a more negative bias.
HUMAN BRAIN MAPPING
(2022)
Article
Pharmacology & Pharmacy
Andrea Varrone, Christoffer Bundgaard, Benny Bang-Andersen
Summary: In central nervous system drug discovery, PET is a crucial tool for assessing the distribution and binding of new chemical entities in the brain. This review summarizes the main applications of PET in early drug development and proposes aligned nomenclatures for key pharmacokinetic parameters to guide PET studies.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Chemistry, Medicinal
Sejung Hwang, Dae Young Lee, Joo-Youn Cho, Jae-Yong Chung, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee
Summary: The study found that after multiple oral doses of DA-8031 at 20, 30, and 40 mg, the systemic exposure of DA-8031 increased in a more than dose-proportional manner and was generally well tolerated. In addition, the genetic polymorphisms of CYP2D6 have an impact on the pharmacokinetics of DA-8031.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Food Science & Technology
Pik Han Chong, Qiaojuan He, Suyun Zhang, Jianwu Zhou, Pingfan Rao, Min Zhang, Lijing Ke
Summary: The biochemistry of human saliva can be influenced by food intake. Although the benefits of tea drinking have been extensively studied, its impact on human saliva remains unknown. This study aimed to investigate the immediate and delayed effects of vine tea, oolong tea, and black tea ingestion on salivary biochemistry and flow rate. The results showed that vine tea consumption increased salivary flow rate, total protein production, thiol levels, malondialdehyde concentration, catalase activity, and antioxidant capacity in saliva. The antioxidant profile of the studied tea samples was positively correlated with salivary flow rate, total protein production, thiol levels, and antioxidant capacity, but negatively correlated with salivary uric acid concentration.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Neurosciences
Friederike Holze, Toya V. Caluori, Patrick Vizeli, Matthias E. Liechti
Summary: This study found that LSD has dose-dependent subjective, physiological, and adverse effects. Most subjects reported good drug effects at doses of 50 μg and above, but also experienced negative effects. The physiological effects of LSD were moderate, with no serious psychological or physical harm observed.
PSYCHOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Paul Bengart, Theo Gruendler, Bodo Vogt
Summary: The study shows that serotonin availability mediates (negative) reciprocal behavior in social decision-making. The reduction of serotonin availability leads to an increase in participants' preference for negative reciprocity in response to expected negative actions. Positive reciprocity, however, remains unaffected by serotonin depletion.
Article
Pharmacology & Pharmacy
Sejung Hwang, Jae-Wook Ko, Heechan Lee, Seokuee Kim, Bongtae Kim, Geun Seog Song, Jungryul Kim
Summary: In healthy subjects, after multiple doses, co-administration of atorvastatin with vonoprazan increased systemic exposure of atorvastatin and the incidence of hypergastrinemia. However, these interactions were not observed when atorvastatin was co-administered with tegoprazan.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Fabienne Teysseire, Valentine Bordier, Aleksandra Budzinska, Lukas Van Oudenhove, Nathalie Weltens, Christoph Beglinger, Bettina K. Woelnerhanssen, Anne Christin Meyer-Gerspach
Summary: This study aimed to investigate the metabolic effects and safety aspects of acute D-allulose and erythritol. The results showed that D-allulose could lower blood glucose and insulin concentrations, while erythritol could reduce ghrelin concentrations. Both sweeteners have potential in reducing sugar intake.
