Article
Environmental Sciences
Hui Zhao, Lin Fu, Hui-Xian Xiang, Ying Xiang, Meng-Die Li, Bian-Bian Lv, Zhu-Xia Tan, Lan Gao, Cheng Zhang, De-Xiang Xu
Summary: The study found that Benzo[a]pyrene can cause acute lung injury and inflammation, while the antioxidant N-acetylcysteine (NAC) can alleviate the pulmonary inflammatory response induced by Benzo[a]pyrene.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Lumin Sui, Ke Yan, Huiting Zhang, Junyu Nie, Xiaogan Yang, Chang-Long Xu, Xingwei Liang
Summary: Our study found that MV significantly alleviated oocyte meiotic defects and quality deterioration caused by BaP exposure, possibly by restoring BaP-mediated oocyte damage through reducing oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yongyi Wei, Hainan Sun, Bing Yan
Summary: Environmental carbon nanomaterials, such as multi-walled carbon nanotubes and graphene oxides, interact with aromatic hydrocarbon pollutants, resulting in adverse effects on ecosystems and human health. The combined toxicity of carbon nanomaterials and benzo[a]pyrene is still unknown. Among the investigated carbon nanomaterials, MWCNTs-NH2, p-GO, and GO-COOH showed some alleviation of the cytotoxicity induced by benzo[a]pyrene, with GO-COOH exhibiting the strongest inhibitory effect. Mechanistically, GO-COOH reduced benzo[a]pyrene-induced cell apoptosis and cytotoxicity by regulating apoptotic proteins and maintaining mitochondrial membrane potential. These findings highlight the importance of the physicochemical properties of carbon nanomaterials in modulating the cytotoxicity of benzo[a]pyrene.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Environmental Sciences
Oscar Samuel Avila-Rosales, Mauricio Diaz-Munoz, Rafael Camacho-Carranza, Elvia Coballase-Urrutia, Jose Pedraza-Chaverri, Jorge Omar Garcia-Rebollar, Jesus Javier Espinosa-Aguirre
Summary: The study found that DRF can modify the expression of ARNT and CYP1A1 genes, and can protect the body from the toxicity of benzo[a]pyrene.
Article
Toxicology
Mustafa Abbass, Yuzhi Chen, Volker M. Arlt, Stephen R. Sturzenbaum
Summary: The study found that exposure to high concentrations of BaP significantly impacted life cycle endpoints of C. elegans, such as reduced reproductive output and shortened lifespan, despite the absence of the classical CYP1A1 bioactivation pathway. DNA damage increased dose-dependently, but no bulky DNA adducts were observed. Transcriptomic analysis identified changes in gene expression related to xenobiotic metabolism, suggesting the involvement of parallel pathways in BaP metabolism in C. elegans.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Environmental Sciences
Hanting Xu, Xinyi Mu, Yubin Ding, Qiman Tan, Xueqing Liu, Junlin He, Rufei Gao, Nanyan Li, Yanqing Geng, Yingxiong Wang, Xuemei Chen
Summary: The study revealed that Benzo(a)pyrene (B(a)P) affects embryo implantation and ovarian CL function in pregnant mice, leading to decreased levels of estrogen and progesterone in the ovaries and impacting oxidative stress and cell apoptosis. Additionally, melatonin was found to alleviate B(a)P-induced ovarian dysfunction by reducing oxidative stress and apoptosis, providing a potential protective mechanism against B(a)P exposure through the melatonin receptor pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Walaa Slouma Hamouda Abd El Naby, Cai Zong, Alzahraa Fergany, Frederick Adams Ekuban, Saleh Ahmed, Yousra Reda, Harue Sato, Sahoko Ichihara, Natsuko Kubota, Shinya Yanagita, Gaku Ichihara
Summary: Epidemiological studies have shown a link between air pollution and dementia. This study focused on the effect of benzopyrene (B[a]P), a soluble fraction of particulate matters, on noradrenergic and serotonergic axons in mouse brains. The results demonstrated that exposure to B[a]P induced degeneration of these axons and suggested the involvement of proinflammatory or inflammation-related genes in B[a]P-induced neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Chong Wang, Fan Zhao, Yun Bai, Chunbao Li, Xinglian Xu, Karsten Kristiansen, Guanghong Zhou
Summary: In this study, we evaluated the protective effects of six polyphenols on BaP-induced cytotoxicity in Caco-2 cells. Our results showed that eriodictyol was superior to naringenin in protecting against BaP-induced toxicity. Proteomics analysis revealed several key proteins involved in the protective mechanisms of eriodictyol.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Abdullah M. Alzahrani, Peramaiyan Rajendran
Summary: Benzo(a)pyrene (B(a)P) is a known carcinogen often found in cigarette smoke, and is implicated in the development of lung cancer. The enzyme CYP1A1 plays a critical role in converting B(a)P into carcinogenic intermediates. Stimulation of the aryl hydrocarbon receptor by B(a)P can activate various signaling cascades. In this study, the flavonoid pinocembrin (PCB) was found to alleviate B(a)P toxicity by inhibiting DNA adduct formation and suppressing the AhR/Src/ERK pathways.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Biophysics
Shiqiang Cheng, Zhicheng Ye, Xiong Wang, Cheng Lian, Yazhuo Shang, Honglai Liu
Summary: In this study, the uptake process of polystyrene nanoparticles (PNPs) combined with benzo(a)pyrene (BAP) molecules by dipalmitoylphosphatidylcholine (DPPC) bilayers was investigated using molecular dynamics simulations. The results showed that the PNPs can adsorb and accumulate BAP molecules in water and then enter DPPC bilayers, with the adsorbed BAP promoting the penetration of PNPs by hydrophobic effect. The process of BAP-PNP combinations penetrating DPPC bilayers can be summarized into four steps: adhesion, uptake, detachment, and depolymerization. The amount of adsorbed BAP also affects the properties of DPPC bilayers and enhances cytotoxicity. This study provides insights into the transmembrane process and the effects of absorbed BAP on the behavior of polystyrene nanoparticles, as well as the potential damage to human health.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Environmental Sciences
Tingyi Zhao, Huide Miao, Zhanfei Song, Yangyang Li, Na Xia, Zhiyan Zhang, Hongmei Zhang
Summary: In this study, the intervention effect of metformin (MET) on cognitive dysfunction induced by B[a]P in mice was evaluated. The results showed that B[a]P caused cognitive impairment, neuronal damage, and glucolipid metabolism disorder, which were alleviated by MET intervention. MET regulated glucolipid metabolism via inhibiting the FTO/FoxO6 pathway, providing a scientific basis for the neurotoxicity and prevention strategies of B[a]P.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Food Science & Technology
Yunqing Li, Ningjing Liang, Tingting Tang, Zhijian Zheng, Muting Chen, Jiao Mo, Ning Zhang, Simi Liao, Yu Lei, Yijie Wu, Chunhua Lan, Huan Ding, Bingxin Du, Mei Feng, Xinhang Wang, Xiaoying Li, Yue Huang, Cailing Lu, Shen Tang, Xiyi Li
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and Benzo[a]pyrene (BaP) is a recognized potent carcinogen. This study found that low-dose BaP induces hepatic steatosis by inhibiting autophagy and promoting lipid deposition, providing new insights into the pathogenesis of NAFLD induced by environmental exposure to low-dose BaP.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yueming Sun, Ying Li, Hong Liang, Ming Li, Ye Liu, Litao Wang, Weijian Lai, Teng Tang, Yongzhao Diao, Yuhong Bai, Christian Isak Jorgensen, Wanghui Xu, Dawen Gao
Summary: A Trametes versicolor isolate from the Changbai Mountain showed effective degradation activity for benzo[a]pyrene (BaP), a high molecular weight polycyclic aromatic hydrocarbon (PAH) compound. Through genomic analysis and transcriptomic/proteomic studies, a BaP-responsive laccase, TvLac5, was identified and found to have a 21-fold higher degradation activity for BaP compared to other homologous laccases, as well as a 3.6-fold higher activity than a commercial laccase product derived from T. versicolor.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shengxian Liang, Haimei Bo, Yue Zhang, Hongcheng Zhen, Li Zhong
Summary: This study found that alizarin displays agonistic activities to the AHR receptor through activating the AHR-CYP1A1 signaling pathway in HepG2 cells, which may lead to an increased risk for cancer development.
Article
Agriculture, Multidisciplinary
Xiaomin Zhang, Gaofeng Hu, Chaoyang Xu, Wen Nie, Kezhou Cai, Hongmei Fang, Baocai Xu
Summary: This study investigated the effect of ginger and its key compounds on the formation of BaP in charcoal-grilled pork sausages. The results showed that increasing the addition of ginger significantly increased the DPPH scavenging activity and the inhibition rate of BaP. Phenolic compounds, particularly eugenol, 6-gingerol, 6-paradol and 6-shogaol, played a key role in inhibiting BaP formation through the inhibition of lipid oxidation.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Pharmacology & Pharmacy
Sayoko Ito-Harashima, Kazuhiro Shiizaki, Masanobu Kawanishi, Koji Kakiuchi, Kana Onishi, Ryoichi Yamaji, Takashi Yagi
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2015)
Article
Toxicology
Satoko Matsui, Sayoko Ito-Harashima, Yuji Sugimoto, Eiji Takada, Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi
TOXICOLOGY IN VITRO
(2016)
Article
Genetics & Heredity
Nozomi Akiba, Kazuhiro Shiizaki, Yoshitaka Matsushima, Osamu Endo, Kazuho Inaba, Yukari Totsuka
Article
Oncology
Togo Ikuta, Yasuhito Kobayashi, Masato Kitazawa, Kazuhiro Shiizaki, Naoki Itano, Tetsuo Noda, Sven Pettersson, Lorenz Poellinger, Yoshiaki Fujii-Kuriyama, Shun'ichiro Taniguchi, Kaname Kawajiri
Article
Biotechnology & Applied Microbiology
Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2013)
Article
Pharmacology & Pharmacy
Kazuhiro Shiizaki, Tomoya Yoshikawa, Eiji Takada, Shizuma Hirose, Sayoko Ito-Harashima, Masanobu Kawanishi, Takashi Yagi
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2014)
Article
Multidisciplinary Sciences
Kazuhiro Shiizaki, Kenta Kido, Yasuhiro Mizuta
Article
Multidisciplinary Sciences
Yukari Totsuka, Yuya Maesako, Hanako Ono, Momoko Nagai, Mamoru Kato, Min Gi, Hideki Wanibuchi, Shoji Fukushima, Kazuhiro Shiizaki, Hitoshi Nakagama
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
(2020)
Article
Genetics & Heredity
Sayoko Ito-Harashima, Mami Matano, Kana Onishi, Tomofumi Nomura, Saki Nakajima, Shingo Ebata, Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi
GENES AND ENVIRONMENT
(2020)
Review
Genetics & Heredity
Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi
GENES AND ENVIRONMENT
(2017)
Article
Pharmacology & Pharmacy
Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi
DRUG METABOLISM AND DISPOSITION
(2014)
Article
Pharmacology & Pharmacy
Kazuhiro Shiizaki, Seiichiroh Ohsako, Masanobu Kawanishi, Takashi Yagi
MOLECULAR PHARMACOLOGY
(2014)