期刊
ANALYST
卷 140, 期 15, 页码 4949-4966出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5an00171d
关键词
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资金
- BARD
- United States - Israel Binational Agricultural Research and Development Fund
- Vaadia-BARD Postdoctoral Fellowship Award [FI-494-13]
- National Institution of Health (NIH) [AI095125, GM097509, GM094802, GM107550, S10RR029121]
- European Union [305259]
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR029121] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI095125] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM097509, R01GM094802, R01GM107550] Funding Source: NIH RePORTER
Since the time Van Leeuwenhoek was able to observe microbes through a microscope, an innovation that led to the birth of the field of microbiology, we have aimed to understand how microorganisms function, interact and communicate. The exciting progress in the development of analytical technologies and workflows has demonstrated that mass spectrometry is a very powerful technique for the interrogation of microbiology at the molecular level. In this review, we aim to highlight the available and emerging tools in mass spectrometry for microbial analysis by overviewing the methods and workflow advances for taxonomic identification, microbial interaction, dereplication and drug discovery. We emphasize their potential for future development and point out unsolved problems and future directions that would aid in the analysis of the chemistry produced by microbes.
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