Article
Clinical Neurology
Karin Due Bruun, Hanne Irene Jensen, Morten Rune Blichfeldt-Eckhardt, Henrik Bjarke Vaegter, Palle Toft, Kirstine Amris, Nina Kvorning
Summary: Fibromyalgia was found to be severely under-diagnosed among patients with high impact chronic pain referred to tertiary care in two pain rehabilitation centers in Denmark. The 2016 diagnostic criteria demonstrated sufficient discriminatory properties, suggesting that the fibromyalgia survey questionnaire can be used as a screening tool to assist in identifying fibromyalgia in this patient population.
SCANDINAVIAN JOURNAL OF PAIN
(2022)
Article
Critical Care Medicine
Helene Korvenius Nedergaard, Serkan Korkmaz, Hanne Tanghus Olsen, Hanne Irene Jensen, Thomas Strom, Palle Toft
Summary: This study aimed to obtain knowledge on patients who experienced failure of non-sedation. Findings revealed that patients with non-sedation failure were more often male and predominantly received propofol as rescue sedation. Additionally, these patients had poorer outcomes in various aspects compared to those with non-sedation success.
JOURNAL OF CRITICAL CARE
(2022)
Article
Medicine, General & Internal
Jakob Oxlund, Palle Toft, Mikael Sorberg, Torben Knudsen, Poul Jorgen Jennum
Summary: Sleep deprivation is common in the ICU and is associated with delirium and increased mortality. Dexmedetomidine has sedative and analgesic properties while preserving sleep architecture. This study aims to compare the effects of dexmedetomidine and placebo on sleep quality in critically ill mechanically ventilated patients.
Article
Emergency Medicine
Pooya Rajabaleyan, Jens Michelsen, Uffe Tange Holst, Soren Moller, Palle Toft, Jan Luxhoi, Musa Buyukuslu, Aske Mathias Bohm, Lars Borly, Gabriel Sandblom, Martin Kobborg, Kristian Aagaard Poulsen, Uffe Schou Love, Sophie Ovesen, Christoffer Grant Solling, Birgitte Morch Sondergaard, Marianne Lund Lomholt, Dorthe Ritz Moller, Niels Qvist, Mark Bremholm Ellebaek
Summary: Secondary peritonitis is a severe condition with high mortality. This study aims to compare the potential benefits and disadvantages of vacuum-assisted closure (VAC) and primary closure with relaparotomy on-demand (ROD) as treatment options.
WORLD JOURNAL OF EMERGENCY SURGERY
(2022)
Article
Anesthesiology
Jimmy Hojberg Holm, Peter Bjorn Licht, Palle Toft, Claus Andersen
Summary: This study provides new information on various aspects of epidural catheter insertion, including procedural pain, duration, failure rates, and the impact of experience. The study found differences between expected and actual pain levels, as well as the influence of placement technique and number of attempts. Long-term side effects such as persistent pain and sensory disturbances were also observed.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Review
Clinical Neurology
Carl-Henrik Nordstrom, Axel Forsse, Rasmus Peter Jakobsen, Simon Molstrom, Troels Halfeldt Nielsen, Palle Toft, Urban Ungerstedt
Summary: The microdialysis technique was initially developed for monitoring neurotransmitters in animals and has since been adopted for clinical use. It has shown potential in studying cerebral energy metabolism and evaluating blood-brain barrier function. Understanding the different biochemical information obtained from various techniques is important, as microdialysis reflects variables in a narrow zone of interstitial fluid surrounding the probe. Bedside microdialysis primarily reflects cerebral energy metabolism through measured levels of glucose, lactate, pyruvate, and the lactate to pyruvate ratio.
FRONTIERS IN NEUROLOGY
(2022)
Article
Anesthesiology
Jakob Oxlund, Torben Knudsen, Mikael Sorberg, Thomas Strom, Palle Toft, Poul Jorgen Jennum
Summary: The study aimed to evaluate the effect of dexmedetomidine on sleep quality and quantity in mechanically ventilated ICU patients. The results showed that dexmedetomidine treatment significantly increased sleep efficiency and total sleep time, without elimination of REM sleep.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Health Care Sciences & Services
Hans-Christian Thorsen-Meyer, Davide Placido, Benjamin Skov Kaas-Hansen, Anna P. Nielsen, Theis Lange, Annelaura B. Nielsen, Palle Toft, Jens Schierbeck, Thomas Strom, Piotr J. Chmura, Marc Heimann, Kirstine Belling, Anders Perner, Soren Brunak
Summary: In this study, researchers trained a deep learning model to predict the survival of patients in intensive care units (ICUs) based on electronic patient record data. The deep learning models outperformed traditional models and showed potential for providing individualized survival estimates in data-rich settings such as ICUs.
NPJ DIGITAL MEDICINE
(2022)
Article
Anesthesiology
Jakob Oxlund, Torben Knudsen, Helle Leonthin, Palle Toft, Poul Jorgen Jennum
Summary: Sleep deprivation in the intensive care unit (ICU) is common and linked to delirium and higher mortality. Polysomnography (PSG) is the gold standard for sleep evaluation, but practical limitations lead to the use of subjective sleep assessment (SSA) in many ICUs. However, the agreement between SSA and PSG remains unclear, and SSA may overestimate total sleep time (TST). This study found that the agreement between SSA and PSG was low in mechanically ventilated ICU patients, and there was a significant overestimation of TST when using SSA.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Clinical Neurology
Morten Rune Blichfeldt-Eckhardt, Dorte Aalund Olsen, Rikke Fredslund Andersen, Palle Toft, Laila Bendix
Summary: The purpose of this study was to examine the cerebrospinal fluid (CSF) of patients with post cholecystectomy syndrome and healthy volunteers to determine if there were signs of PGE2 and cytokine mediated central sensitization. The results showed that there were elevated levels of PGE2 metabolite (PGEM) in the CSF of patients with post cholecystectomy syndrome and visceral hyperalgesia, indicating a possible inflammatory component to the pain. Additionally, there was an overrepresentation of the CT genotype in the rs5275 SNP of the Cox2 gene in the pain group.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Pediatrics
Ulla Lei Larsen, Gitte Zachariassen, Soren Moller, Wilhelmine Ursin Forre, Ingvild Grosle, Susanne Halken, Anne Maria Herskind, Thomas Strom, Palle Toft, Mark Ellebaek, Niels Qvist
Summary: This study retrospectively collected data on nutritional support in 45 infants with congenital diaphragmatic hernia (CDH) and found that early enteral nutrition is feasible and may reduce the need for parental nutrition and shorten the time to achieve full enteral nutrition in the postoperative period.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Anesthesiology
Sandra A. Thy, Andreas O. Johansen, Andre Thy, Henrik H. Sorensen, Jesper Molgaard, Nicolai B. Foss, Palle Toft, Christian S. Meyhoff, Eske K. Aasvang
Summary: Postoperative monitoring of circulation and respiration is crucial for the management of patients. This study investigated the association between clinical interventions and changes in transcutaneous blood gases. The results suggest that changes in transcutaneous oxygen and carbon dioxide might have clinical value in a postoperative setting.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Critical Care Medicine
Simon Molstrom, Troels Halfeld Nielsen, Carl-Henrik Nordstrom, Axel Forsse, Soren Moller, Soren Veno, Dmitry Mamaev, Tomas Tencer, Asta Theodorsdottir, Thomas Kroigard, Jacob Moller, Christian Hassager, Jesper Kjaergaard, Henrik Schmidt, Palle Toft
Summary: This study aimed to assess the effect of different blood pressure levels on global cerebral metabolism in comatose patients resuscitated from out-of-hospital cardiac arrest. The results showed that targeting a higher mean arterial blood pressure (MAP) did not significantly improve cerebral energy metabolism within 96 hours of post-resuscitation care. Patients with a poor clinical outcome exhibited significantly worse biochemical patterns, indicating that insufficient tissue oxygenation and recirculation during the initial hours after resuscitation were important factors determining neurological outcome.
Article
Critical Care Medicine
Clara Marie Bode, Simon Bruun Kristensen, Hanne Tanghus Olsen, Camilla Dyremose Cornwall, Lars Roberg, Olav Monsson, Thomas Kroigard, Palle Toft, Christoph P. Beier
Summary: The study aims to investigate the risk factors for the development of postictal encephalopathy and its impact on survival after discharge. The results show that postictal encephalopathy is common after status epilepticus and is associated with poor long-term survival. Seizure characteristics are not independently associated with postictal encephalopathy, while etiology, duration of sedation, age, and premorbid condition are the major risk factors for its development.
NEUROCRITICAL CARE
(2023)
Article
Health Care Sciences & Services
Anne C. Brochner, Peter Lindholm, Margrethe J. Jensen, Palle Toft, Finn L. Henriksen, Jens F. Lassen, Soren Mikkelsen
Summary: This study challenges the traditional belief that myoclonic status is a sign of poor prognosis after out-of-hospital cardiac arrest. The results show that myoclonic status may not necessarily indicate poor outcome when not associated with EEG-verified status epilepticus.