Article
Endocrinology & Metabolism
Sayaka Yamada, Kazuhiko Horiguchi, Masako Akuzawa, Koji Sakamaki, Eijiro Yamada, Atsushi Ozawa, Isao Kobayashi, Yohnosuke Shimomura, Yasuyuki Okamoto, Tetsuro Andou, Yoshitaka Andou, Masanobu Yamada
Summary: This study investigated the age- and sex-based differences in serum thyroid-stimulating hormone (TSH) and thyroid hormone levels in euthyroid individuals. The results showed that using age- and sex-specific reference ranges can avoid over- or underdiagnosis of subclinical thyroid dysfunction.
Article
Endocrinology & Metabolism
Matthew D. Ettleson, Wesley H. Prieto, Pedro S. T. Russo, Jose de Sa, Wen Wan, Neda Laiteerapong, Rui M. B. Maciel, Antonio C. Bianco
Summary: Despite changes in thyroid-stimulating hormone (TSH) levels, small adjustments in levothyroxine (LT4) dose do not provide clinical benefit. The changes in serum total triiodothyronine (T3) levels may not accurately reflect the changes in TSH levels. Therefore, dose changes in LT4 may minimally affect T3 levels without significant clinical benefit.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Valerie Anne Galton, Arturo Hernandez
Summary: This article explores the importance of thyroid hormone metabolism and its role in maintaining hormone balance, emphasizing that thyroid hormone metabolism is not solely for degradation and elimination but plays a crucial role in regulating various organs and tissues.
Review
Endocrinology & Metabolism
Nilkanta Chakrabarti, Pradip K. Sarkar, Arun K. Ray, Joseph V. Martin
Summary: This article provides a comprehensive review of the contributions and studies in the field of nongenomic actions of thyroid hormones in the adult mammalian brain, focusing on the work of Mary B. Dratman and other researchers. The research findings suggest that thyroid hormones and their derivatives have direct actions at synaptic regions, which may contribute to the physiological and pathophysiological roles of thyroid hormone in psychobehavioral control. However, further studies are needed to understand the exact mode of nongenomic actions of thyroid hormones in the adult mammalian brain.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Se-Min Kim, Vitaly Ryu, Sari Miyashita, Funda Korkmaz, Daria Lizneva, Sakshi Gera, Rauf Latif, Terry F. Davies, Jameel Iqbal, Tony Yuen, Mone Zaidi
Summary: TSH, traditionally known for regulating thyroid function, also plays a crucial role in skeletal remodeling and bone metabolism. Studies using genetically modified mouse models have shown an independent role of TSH in bone health, beyond its relationship with thyroid hormone levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Agriculture, Dairy & Animal Science
Maria Chmurska-Gasowska, Natalia Sowinska, Sylwia Palka, Michal Kmiecik, Joanna Lenarczyk-Knapik, Lukasz Migdal
Summary: Thyroid hormones are crucial for metabolism, energy balance, and reproduction. By comparing thyroid hormone analysis in the urine and feces of domestic rabbits with serum analyses, it was found that free triiodothyronine can be accurately and reliably measured in the urine and feces.
Article
Endocrinology & Metabolism
Elisa Merchan-Ramirez, Guillermo Sanchez-Delgado, Cristina Arrizabalaga-Arriazu, Borja Martinez-Tellez, Andrea Mendez-Gutierrez, Manuel Munoz-Torres, Jose M. Llamas-Elvira, Jonatan R. Ruiz
Summary: The study found that cold exposure led to an increase in FT4 levels and a decrease in TSH levels, but had no effect on FT3 serum concentration. There were no associations between TSH and THs levels at thermoneutral or cold-induced conditions and BAT volume, F-18-FDG uptake, and mean radiodensity in young healthy euthyroid adults.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Gilad Karavani, Lina Daoud-Sabag, Cherut Chay, David Gillis, David Strich
Summary: This study aimed to evaluate the relationship between TSH and thyroid hormones during pregnancy in order to determine if TSH is an adequate screening tool. The findings suggest that TSH levels beyond the range accepted as normal do not, in most cases, reflect abnormal thyroid hormone levels during pregnancy. Therefore, TSH is not a good screen for overt hypothyroidism in pregnancy.
HORMONE AND METABOLIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Asieh Mousavi, Negin Salamat, Alireza Safahieh
Summary: The study evaluated the effects of phenanthrene on the thyroid tissue of Arabian seabream, showing significant impact on the thyroid function of fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Mike Stedman, Peter Taylor, Lakdasa Premawardhana, Onyebuchi Okosieme, Colin Dayan, Adrian H. Heald
Summary: Geographical variation exists in the prescribing of levothyroxine and liothyronine in English general practices, with specific factors such as clinical commissioning group membership and proportion of patients with diabetes and antidepressant prescriptions influencing prescribing patterns. Despite efforts to limit liothyronine prescribing, both levothyroxine and liothyronine continue to be prescribed, with factors such as antidepressant prescriptions and diabetes control levels impacting liothyronine prescribing.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Biophysics
Robson Mateus Freitas Silveira, Paulo Rogerio Garcia, Sergio Luis de Castro, Alessandra Arno, Iran Jose Oliveira da Silva
Summary: This study evaluated and compared the physiological performance of different genetic groups of sheep in a hot weather environment. The results showed that crossbred breeds had a higher metabolism and were more efficient at dissipating heat through thermolysis. Thyroid hormones displayed a normal circadian rhythm, with the exception of one genetic group. The environmental factors had minimal impact on the hormone levels.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2023)
Article
Nutrition & Dietetics
Larissa Cristina Fontenelle, Mayara Monte Feitosa, Taynah Emannuelle Coelho Freitas, Juliana Soares Severo, Jennifer Beatriz Silva Morais, Gilberto Simeone Henriques, Francisco Erasmo Oliveira, Jose Machado Moita Neto, Dilina do Nascimento Marreiro
Summary: Obese women showed impairment in selenium homeostasis, but this did not seem to adversely affect thyroid metabolism. Free triiodothyronine (fT3) and free thyroxine (fT4) levels were higher in obese women, and there was a negative correlation between plasma selenium and serum fT4 levels.
CLINICAL NUTRITION ESPEN
(2021)
Article
Endocrinology & Metabolism
Aleksandra Mikolajczak, Katarzyna Kufel, Renata Bokiniec
Summary: This study indicates the need for adjusted FT4 values in preterm infants based on gestational age, and ultrasound thyroid imaging may be helpful in evaluating suspected thyroid disorders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Valerie Anne Galton, P. Reed Larsen, Marla J. Berry
Summary: This minireview outlines the historical events that led to the discovery and recognition of deiodinases and their importance in thyroid hormone action. It discusses the identification and cloning of the 3 deiodinase genes.
Article
Endocrinology & Metabolism
Gloria Hoi-Yee Li, Ching-Lung Cheung, Elaine Yun-Ning Cheung, Wai-Chi Chan, Kathryn Choon-Beng Tan
Summary: Genetically determined increase in TSH levels within the reference range may lower the risk of Alzheimer's disease, with possible mediation by atrial fibrillation, blood pressure, while no causal association was found between FT4 levels and Alzheimer's disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Henna Hyrkas-Palmu, Tiina M. Ikaheimo, Tiina Laatikainen, Pekka Jousilahti, Maritta S. Jaakkola, Jouni J. K. Jaakkola
SCIENTIFIC REPORTS
(2018)
Article
Environmental Sciences
Soile Puhakka, Riitta Pyky, Tiina Lankila, Maarit Kangas, Jarmo Rusanen, Tiina M. Ikaheimo, Heli Koivumaa-Honkanen, Raija Korpelainen
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2018)
Article
Cardiac & Cardiovascular Systems
Tiina M. Ikaheimo, Miia Lansitie, Rasmus Valtonen, Heidi E. Hintsala, Niilo Ryti, Juha Perkiomaki, Matti Mantysaari, Arto J. Hautala, Jouni J. K. Jaakkola
BMC CARDIOVASCULAR DISORDERS
(2019)
Article
Peripheral Vascular Disease
Heidi E. Hintsala, Antti M. Kiviniemi, Riitta Antikainen, Matti Mantysaari, Jari Jokelainen, Juhani Hassi, Mikko P. Tulppo, Karl-Heinz Herzig, Sirkka Keinanen-Kiukaanniemi, Hannu Rintamaki, Jouni J. K. Jaakkola, Tiina M. Ikaheimo
AMERICAN JOURNAL OF HYPERTENSION
(2019)
Article
Physiology
Rasmus I. P. Valtonen, Tiina M. Ikaheimo, Heidi E. Hintsala, Niilo R. I. Ryti, Arto Hautala, Juha S. Perkiomaki, C. G. Crandall, Matti Mantysaari, Jouni J. K. Jaakkola, Antti M. Kiviniemi
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2020)
Article
Environmental Sciences
Chotirot Chotiphan, Nipaporn Auttanate, Suchinda Jarupat Maruo, Simo Nayha, Kirsi Jussila, Sirkka Rissanen, Penpatra Sripaiboonkij, Tiina M. Ikaheimo, Jouni J. K. Jaakkola, Wantanee Phanprasit
Article
Public, Environmental & Occupational Health
Wantanee Phanprasit, Chotirot Chotiphan, Nipaporn Auttanate, Suchinda Jarupat Maruo, Kirsi Jussila, Sirkka Rissanen, Penpatra Sripaiboonkij, Tiina M. Ikaheimo, Jouni J. K. Jaakkola, Simo Nayha
Summary: This study investigated the prevalence of cold-related pain (CRP) among Thai chicken industry workers and identified vulnerable subgroups such as forklift drivers, manufacturing and storage workers, and highly educated office staff. Women were found to have more CRP in several body sites compared to men. The majority of workers suffered from CRP, indicating a need for intensified protective measures.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Riitta Pyky, Soile Puhakka, Tiina M. Ikaheimo, Tiina Lankila, Maarit Kangas, Matti Mantysaari, Timo Jamsa, Raija Korpelainen
Summary: The study found that maternal physical activity was positively associated with the physical activity of adolescent men living in built environments, while paternal physical activity was positively associated with the physical activity of adolescent men living in natural environments. Self-rated health was positively correlated with physical activity level, while individuals with depressive symptoms were more likely to be physically inactive.
JOURNAL OF ENVIRONMENTAL AND PUBLIC HEALTH
(2021)
Article
Physiology
Rasmus I. P. Valtonen, Heidi H. E. Hintsala, Antti Kiviniemi, Tuomas Kentta, Craig Crandall, Wouter van Marken Lichtenbelt, Juha Perkiomaki, Arto Hautala, Jouni J. K. Jaakkola, Tiina M. Ikaheimo
Summary: Performing upper-body exercise in a cold environment can increase cardiovascular strain for patients with coronary artery disease. However, there were no significant changes in electric cardiac function observed. The study supports the use of upper-body exercise in the cold for patients with stable CAD.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Wantanee Phanprasit, Pajaree Konthonbut, Wisanti Laohaudomchok, Chaiyanun Tangtong, Tiina M. Ikaeheimo, Jouni J. K. Jaakkola, Simo Nayha
Summary: The study found that highly-educated workers in the poultry industry showed significantly decreased work ability and increased prevalence of low work ability when working in cold areas, whereas low-educated workers did not show significant changes. Highly-educated workers in this industry are identified as a high-risk group that should receive customized advice for improving work ability.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Sport Sciences
Maisa Niemelae, Antti Kiviniemi, Tiina M. M. Ikaheimo, Mikko Tulppo, Raija Korpelainen, Timo Jaemsae, Vahid Farrahi
Summary: A study found that in middle age, more time spent in moderate-to-vigorous physical activity (MVPA) is associated with a lower risk of cardiovascular disease; the greatest risk reduction occurs when sleep time is replaced by MVPA.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Biochemistry & Molecular Biology
Syeda Tayyiba Rahat, Mira Makela, Maryam Nasserinejad, Tiina M. M. Ikaheimo, Henna Hyrkas-Palmu, Rasmus I. P. Valtonen, Juha Roning, Sylvain Sebert, Anni I. Nieminen, Nsrein Ali, Seppo Vainio
Summary: Cell-secreted extracellular vesicles (EVs) have the potential to serve as non-invasive solutions for monitoring health and disease. We developed a protocol to purify and characterize sweat EVs from healthy participants and identified metabolites associated with metabolic changes that may reflect correlations with blood glucose and BMI. This study provides a proof-of-concept for using sweat EVs and their metabolites as a non-invasive approach to monitor wellbeing and changes in diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Janne Alahuhta, Helena Tukiainen, Maija Toivanen, Terhi Ala-Hulkko, Vahid Farrahi, Jan Hjort, Tiina M. Ikaeheimo, Tiina Lankila, Tuija Maliniemi, Soile Puhakka, Henriikka Salminen, Marjo Seppaenen, Raija Korpelainen, Ding Ding
Summary: Our existence on Earth depends on the vital support of nature for our physical and mental health. However, the importance of geodiversity, the diversity of non-living nature, has been overlooked compared to biodiversity. Geodiversity, consisting of geological, geomorphological, soil, and hydrological components, forms the foundation for biodiversity and is necessary for overall human health. This article introduces geodiversity as a driver for planetary health, describing its functions and services, and exploring the intricate relationships between geodiversity, biodiversity, and human health. It also proposes an agenda for recognizing the importance of geodiversity in health-related research and decision making. Geodiversity is an emerging topic with untapped potential in ensuring ecosystem functionality and good living conditions for people in a changing environment.
LANCET PLANETARY HEALTH
(2022)
Review
Sport Sciences
John W. Castellani, Clare M. Eglin, Tiina M. Ikaheimo, Hugh Montgomery, Peter Paal, Michael J. Tipton
Summary: The article discusses the potential cold injuries that can result from exercising in low temperatures, including their impact on exercise performance, prevention, and treatment.
CURRENT SPORTS MEDICINE REPORTS
(2021)
Review
Psychology, Multidisciplinary
Mikko Karmeniemi, Tiina Lankila, Tiina Ikaheimo, Heli Koivumaa-Honkanen, Raija Korpelainen
ANNALS OF BEHAVIORAL MEDICINE
(2018)