Article
Agriculture, Dairy & Animal Science
Zuyue Li, Xiaomeng Li, Zhaoxia Cai, Guofeng Jin, Dong Uk Ahn, Xi Huang
Summary: The study found that three types of chicken soups could promote the recovery of immunosuppressive mice, with each soup having different mechanisms of action. Gushi Chicken Soup showed the best recovery effects, while Honglashan Chicken Soup and Cobb Broiler Soup showed advantages in different aspects.
Article
Veterinary Sciences
Eman I. Hassanen, Ahmed M. Hussien, Sally Mehanna, Eman A. Morsy
Summary: This study evaluated the potential of chitosan-coated silver nanoparticles to enhance the growth performance and immune status of broilers. The results showed that CS/Ag-NCs had better effects than AgNPs in improving body weight gain, feed conversion ratio, feeding and drinking behavior. Additionally, CS/Ag-NCs did not cause histological changes or silver residues.
BMC VETERINARY RESEARCH
(2023)
Letter
Immunology
Joerg Hofmann, Stephanie Kramer, Klaus R. Herrlinger, Kathrin Jeske, Martin Kuhns, Sabrina Weiss, Rainer G. Ulrich, Detlev H. Krueger
Summary: We report the molecular evidence of Tula virus infection in an immunocompetent patient from Germany, showing typical signs of hantavirus disease. Despite being considered nonpathogenic, accumulating evidence suggests that Tula virus infection poses a threat to human health.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Veterinary Sciences
Vasileios Tsiouris, Tilemachos Mantzios, Konstantinos Kiskinis, Jean-Luc Guerin, Guillaume Croville, Georgia D. Brellou, Emmanouela P. Apostolopoulou, Evanthia J. Petridou, Ioanna Georgopoulou
Summary: This case report presents a detailed clinicopathological investigation of an unusual outbreak of inclusion body hepatitis (IBH) in commercial broiler flocks in Macedonia, Greece. The outbreak, caused by Fowl Aviadenoviruses (FAdVs), resulted in higher mortality rates in one specific flock compared to others, despite all flocks testing positive for FAdV. The clinical manifestation included non-specific symptoms and the histopathological examination revealed liver inflammation and necrosis, as well as fibrosis and chronic inflammation in the pancreas.
VETERINARY SCIENCES
(2022)
Article
Biology
Xia Wang, Jiaxuan Cheng, Jiawei Shen, Liguo Liu, Ningning Li, Ning Gao, Feng Jiang, Qi Jin
Summary: The extracellular contractile injection systems (eCISs) are present in the genomes of many bacteria and archaea, with Photorhabdus Virulence Cassette (PVC) being a typical member. PVC delivers effectors directly into mammalian macrophages by loading them into the inner tube and injecting them into the cells, disrupting dNTP pools and actin cytoskeleton formation to kill the target cells.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Materials Science, Ceramics
Chenxu Wang, Pedaballi Sireesha, Jing Shang, John S. McCloy, Jin Liu, Wei -Hong Zhong
Summary: This study presents a green synthesis method to fabricate stable porous Fe2O3 as an anode material for Li-ion batteries. The synthesized material effectively accommodates volume change, reduces pulverization, and alleviates agglomeration, leading to a high capacity.
CERAMICS INTERNATIONAL
(2023)
Article
Emergency Medicine
John Rains, Jacob Kesterson
Summary: Bradycardia can vary in severity and prompt recognition of potential causes is crucial for proper treatment and disposition. This paper presents a case of symptomatic bradycardia in an 89-year-old female caused by ophthalmic timolol, highlighting the importance of careful medication selection.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Immunology
Hongliang Zhang, Jie Gao, Wenxiang Fang, Yujie Tang, Xuan Fang, Tengchuan Jin, Jinhui Tao
Summary: The study indicates that NINJ1 is upregulated during a gout flare, leading to PMR-induced progression of gout. Knockdown and neutralizing antibody targeting NINJ1 show promising potential as therapeutic approaches for gout.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Maged M. Mahmoud, Ahmed M. Al-Hejin, Turki S. Abujamel, Aly M. Ghetas, Haitham A. Yacoub
Summary: The current study investigated the potential use of avian beta-defensin-1 peptide as a candidate agent against coccidiosis infection in broiler chickens. In-silico analysis was employed to study the structure of the peptide and its mode of action. The results showed that treatment with beta-defensin-1 peptide led to a significant reduction in oocyst count and down-regulation of beta-defensin 1 and 4 expression. These findings may contribute to the development of novel approaches for coccidiosis control in broilers.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Immunology
Diana Salomi Ponraj, Michael Lund, Jeppe Lange, Anja Poehlein, Axel Himmelbach, Thomas Falstie-Jensen, Nis Pedersen Jorgensen, Christen Ravn, Holger Bruggemann
Summary: The aim of this pilot study was to investigate the use of metagenomic next-generation sequencing (mNGS) to improve the diagnosis of Cutibacterium acnes-associated orthopaedic implant infections (OIAIs). The results showed that mNGS was able to detect C. acnes DNA in more samples compared to culture, including cases of suspected polymicrobial infections. However, caution should be exercised in interpreting mNGS results due to potential DNA contamination.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Justin Gutierrez, Amanda Bakke, Maritza Vatta, A. Rod Merrill
Summary: This study discovered several plant extracts and flavonoids that effectively inhibit the growth of Streptomyces scabies. Myrrh extract from Commiphora myrrha showed the strongest antibacterial activity against this pathogen.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rumen Harizanov, Nina Tsvetkova, Aleksandra Ivanova, Raina Enikova, Mihaela Videnova, Iskra Rainova, Eleonora Kaneva, Iskren Kaftandjiev, Dimitar Strashimirov, Nina Yancheva-Petrova, Ivan Simeonovski, Viktoria Levterova, Nikolay Yanev
Summary: This study aimed to establish the prevalence of Pneumocystis jirovecii infection in human hosts with different immune status and compare it with classical staining methods. The results showed that real-time PCR had higher sensitivity than staining methods, and the choice of a method for sample collection and examination played an important role in the efficiency of the laboratory diagnostics.
Article
Health Care Sciences & Services
Bozhidar Vergov, Andreana Angelova, Alexandra Baldzhieva, Yordan Kalchev, Georgi Tsochev, Marianna Murdjeva
Summary: Improvements in medical care have transformed severe diseases into chronic conditions, but the treatment and use of medical devices often come with specific complications. This article presents a clinical case of a long-term dialysis patient who acquired a rare opportunistic infection called Gordonia sputi. In recent years, the incidence of Gordonia spp. infections has been increasing among immunocompromised patients with central venous catheters. Isolating and identifying Gordonia spp. is challenging and requires modern techniques. Treatment usually involves persistent therapy and may result in the extraction of the central venous catheter, posing additional risks and costs to the patient. Additionally, this study examines the effects of long-term renal replacement therapy and chronic hepatitis C virus infection on the patient's immune status. Successfully eradicating the infection was achieved through antibiotic therapy and immunostimulation with Inosine pranobex, eliminating the need for central venous catheter replacement.
Article
Medical Laboratory Technology
Moslem Sedaghatalab, Sadegh Nouripour-Sisakht, Seyed Cheraghzadeh, Gholamabas Sabz, Maral Gharaghani
Summary: This case report describes a diabetic patient who developed rhino-cerebral mucormycosis 12 days after severe COVID-19. The patient's symptoms improved following medical and surgical intervention.
CLINICAL LABORATORY
(2022)
Article
Microbiology
Pavel Alexyuk, Andrey Bogoyavlenskiy, Madina Alexyuk, Kuralay Akanova, Yergali Moldakhanov, Vladimir Berezin
Summary: Colibacillosis in chickens can lead to death, weight loss, and economic losses. Antibiotic therapy is currently the main treatment method, but the rise of antibiotic resistance highlights the need for alternative treatments that align with the One Health concept. Phage therapy meets these requirements.
Article
Pharmacology & Pharmacy
Bhaskar Barnwal, Chee-Keng Mok, Jianping Wu, Mandakhalikar Kedar Diwakar, Garvita Gupta, Qi Zeng, Vincent Tak Kwong Chow, Jianxing Song, Y. Adam Yuan, Yee-Joo Tan
ANTIVIRAL RESEARCH
(2015)
Article
Multidisciplinary Sciences
Kedar Diwakar Mandakhalikar, Juwita Norasmara Rahmat, Edmund Chiong, Koon Gee Neoh, Liang Shen, Paul Anantharajah Tambyah
SCIENTIFIC REPORTS
(2018)
Article
Infectious Diseases
Kedar Diwakar Mandakhalikar, Rong Wang, Juwita N. Rahmat, Edmund Chiong, Koon Gee Neoh, Paul A. Tambyah
BMC INFECTIOUS DISEASES
(2018)
Article
Immunology
Vinh T. Dang, Kedar D. Mandakhalikar, Oi-Wing Ng, Yee-Joo Tan
CLINICAL & DEVELOPMENTAL IMMUNOLOGY
(2013)
Meeting Abstract
Urology & Nephrology
K. D. Mandakhalikar, J. N. Rahmat, M. Li, T. Lau, K. G. Neoh, E. Chiong
Meeting Abstract
Urology & Nephrology
K. D. Mandakhalikar, J. N. Rahmat, R. Wang, K. G. Neoh, P. A. Tambyah, E. Chiong
Meeting Abstract
Chemistry, Multidisciplinary
KoonGee Neoh, Min Li, Juwita Rahmat, Kedar Mandakhalikar, En Tang Kang, Edmund Chiong
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Meeting Abstract
Urology & Nephrology
Kedar Diwakar Mandakhalikar, Koon Gee Neoh, Paul Anantharajah Tambyah, Edmund Chiong, Rong Wang, Rongyuan Ray Chua
INTERNATIONAL JOURNAL OF UROLOGY
(2016)
Article
Veterinary Sciences
Kriengwich Limpavithayakul, Nataya Charoenvisal, Somsak Pakpinyo
Summary: The PCR-RFLP molecular assay was verified as a convenient technique for detecting the MS-H vaccine strain, and the immune response mechanisms in vaccinated layer-type chickens were characterized. Vaccination stimulated immune response mechanisms in chickens with no significant difference between single and double doses.
Article
Veterinary Sciences
Doan Hoang Phu, Ruethai Narinthorn, Nguyen Thi Nhung, Niwat Chansiripornchai, Patrick J. Blackall, Conny Turni, Juan Carrique-Mas, Thotsapol Thomrongsuwannakij
Summary: Chicken in southern Thailand has different prevalence and resistance patterns of Campylobacter. Commercial broilers exhibit higher resistance to quinolones and lower resistance to macrolides and tetracycline compared to native chickens. Resistance patterns are more consistent within farms, and commercial broilers show higher homogeneity. Phenotypic and genotypic resistance have partial agreement among isolates.
Article
Veterinary Sciences
Sanjiv Kumar, Madhurendu Kumar Gupta, Sanjit Kumar, Tanmoy Rana
Summary: This study evaluated the relative efficacy of allopurinol and febuxostat, two important anti-gout agents, in controlling hyperuricemia/gout using a poultry model. The results showed that both allopurinol and febuxostat have definite potential for ameliorating hyperuricemia and gout in poultry, with febuxostat showing better effects compared to allopurinol.
Article
Veterinary Sciences
Robert Jan Molenaar, Remco Dijkman, Christiaan ter Veen, Annet Heuvelink, Fiona van Kaam, Marieke Augustijn, Anneke Feberwee
Summary: This report describes an outbreak of Salmonella Pullorum (SP) in a Dutch laying flock, causing increased mortality, decreased egg production, and neurological signs. SP was frequently isolated from various organs, and immunostaining showed cerebral granulomas in birds with neurological signs. Vaccination did not affect the detection of SP antibodies. Some clinically healthy birds had ovarian lesions associated with SP contact, but carrier status could not be confirmed. Phylogenetic analysis showed clonality of the SP isolates within the outbreak.
Article
Veterinary Sciences
Yingfei Sun, Yingjie Wang, Lulu Wang, Mengyun Zou, Xiuli Peng
Summary: This study investigates the regulation of miR-33-5p gene expression during MG infection. The researchers found an upregulation in pri-miR-33-5p and pre-miR-33-5p expression, indicating transcriptional regulation. They identified a binding motif for STAT5 in the miR-33-5p promoter element and showed that STAT5 modulates miR-33-5p transcription in response to MG infection. The overexpression of STAT5 led to increased miR-33-5p expression while suppressing JNK1 expression.