Article
Veterinary Sciences
Shuangshuang Guo, Yu Xi, Yi Xia, Tao Wu, Di Zhao, Zhengfan Zhang, Binying Ding
Summary: The study demonstrated the beneficial effects of Lactobacillus fermentum and Bacillus coagulans in attenuating intestinal inflammation and microbial dysbiosis in broilers challenged with Clostridium perfringens. Both probiotics showed significant modulation on the immune system and intestinal microbiota of the challenged birds, effectively reducing inflammation and restoring microbial balance.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Kosar Gharib-Naseri, Sarbast Kheravii, Chake Keerqin, Robert A. Swick, Mingan Choct, Shu-Biao Wu
Summary: The primary cause of necrotic enteritis in chickens is the NetB-positive Clostridium perfringens bacterium. This study evaluated the impact of two pathogenic C. perfringens strains on gut health and gene expression in broilers, finding that the challenge is detrimental to performance and different strains can modulate the severity of the disease through gene expression.
Article
Agriculture, Dairy & Animal Science
Dorthe Sandvang, Line Skjoet-Rasmussen, Mette Dines Cantor, Greg F. Mathis, Brett S. Lumpkins, Alfred Blanch
Summary: The study evaluated the probiotic effects of 3 different Bacillus strains and their combination on broiler chickens through in vitro and in vivo experiments. The results showed that the multi-strain combination significantly improved the performance and reduced the necrotic enteritis lesion scores of the chickens, as well as decreased the mortality rate caused by necrotic enteritis.
Article
Microbiology
Revathi Shanmugasundaram, Jeferson Lourenco, Walid Al Hakeem, Madison M. Dycus, Todd J. Applegate
Summary: Fusarium toxins in poultry diets negatively affect growth and intestinal integrity in broiler chickens. This study investigated the effects of combined fumonisins (FUM) and deoxynivalenol (DON) on the cecal microbiome and predicted metabolic functions in broilers challenged with Clostridium perfringens. The FUM and DON contaminated diet decreased body weight gain and altered the microbial composition in the cecal contents, while dysregulating intestinal functions and impairing the gut immune response.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Larissa Justino, Ana A. S. Baptista, Marielen de Souza, Maisa F. Menck-Costa, Barbara G. Pires, Claudineia E. Cicero, Ana P. F. R. L. Bracarense, Vanessa M. Kaneko, Alexandre Oba, Adriano S. Okamoto, Raphael L. Andreatti Filho
Summary: The ban of antibiotic growth promoters in animal feed has increased the number of cases of necrotic enteritis (NE) in broilers, which greatly impacts the poultry industry. However, inducing NE in experimental settings is challenging due to its multifactorial nature. This study evaluated the effects of immunosuppression, infection, or both, by Eimeria spp., on the predisposition to NE in broilers fed a wheat-based diet and challenged with different strains of Clostridium perfringens. The results suggest a synergistic effect between the strain of C. perfringens and the predisposing factors, but further evaluation is needed.
Article
Agriculture, Dairy & Animal Science
Xieying Ding, Xin Zhong, Yunqiao Yang, Geyin Zhang, Hongbin Si
Summary: This study confirmed the combined inhibitory effect of citric acid (CA) and magnolol (MA) on C. perfringens. The optimal ratio of CA to MA was found to be 50:3, with a dosage of 265 μg/mL inhibiting the growth of C. perfringens and causing damage to its cell structure. The combination of CA and MA exhibited therapeutic effects on C. perfringens challenge in chickens by inhibiting inflammation and enhancing antioxidant capability. Rating: 8/10.
Article
Veterinary Sciences
Hyun-Gwan Lee, Yoo-Bhin Kim, Sang-Hyeok Lee, Jun-Ok Moon, Jong-Pyo Chae, Yu-Jin Kim, Kyung-Woo Lee
Summary: The study aimed to evaluate the antibacterial effects of bacteriophages (BPs) in broiler chickens challenged with Clostridium perfringens. The results showed that dietary encapsulated or powdered BPs reversed the C. perfringens-induced increase in crypt depth and reduced C. perfringens counts in the cecum. Chickens fed with encapsulated BPs also had higher serum IgA levels.
VETERINARY SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Ali Daneshmand, Hassan Kermanshahi, Javid Mohammed, Mohammad Hadi Sekhavati, Ali Javadmanesh, Monireh Ahmadian, Marzieh Alizadeh, Jamshid Razmyar, Raveendra R. Kulkarni
Summary: This study evaluated the effects of C. perfringens on the intestines, microbial colonization, and immune responses in broiler chickens. The results showed that C. perfringens can cause intestinal damage, changes in microbial populations, and trigger host immune responses. Furthermore, using coccidia and a wheat-based diet predisposition may facilitate better research on C. perfringens.
Article
Agriculture, Dairy & Animal Science
Marta Kubis, Pawel Kolodziejski, Ewa Pruszynska, Maciej Sassek, Pawel Konieczka, Pawel Gorka, Jadwiga Flaga, Dorota Katarzynska-Banasik, Marcin Hejdysz, Malgorzata Szumacher, Adam Cieslak, Sebastian A. Kaczmarek
Summary: The present study investigated the effects of emulsifier, xylanase, and a combination of both on the digestibility of nutrients and growth performance of broiler chickens. The results showed that the addition of emulsifiers to the diet significantly improved body weight gain and feed conversion ratio, while the combined use of xylanase and emulsifier resulted in increased degradation of neutral detergent fiber.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2022)
Article
Physiology
Xiao Xu, Shunli Yang, Joshua Seun Olajide, Zigang Qu, Zhenxing Gong, Jing Wang, Yanbing Zhang, Heng Wang, Ling Xiong, Kun Zhang, Enmin Zhou, Jianping Cai
Summary: The study showed that dietary supplementation of C. butyricum in broilers with necrotic enteritis (NE) improved chicken growth performance, intestinal integrity and barrier function, and immunological status. The supplementation enhanced weight gain, protected intestinal morphology, and reduced susceptibility to C. perfringens infection. No statistically significant difference was observed between adding C. butyricum on day 1 or day 14.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Shifeng Wang, Charles L. Hofacre, Soo-Young Wanda, Jingyu Zhou, Richard A. Callum, Bob Nordgren, Roy Curtiss
Summary: We have improved a vaccine for C. perfringens by integrating a triple-sugar regulation system and a DsifA mutation, which resulted in increased protection and a safer profile.
Article
Veterinary Sciences
Yang-Chi Fan, Yi-Tei Wu, Yi-Hsieng Samuel Wu, Chia-Lan Wang, Chung-Hsi Chou, Yi-Chen Chen, Hsiang-Jung Tsai
Summary: The addition of trehalose to broiler feed does not have a negative impact on broiler farming, but it can increase the Lactobacillus counts in the chicken gut, improving gut health. This research has significance in studying the characteristics of trehalose and finding alternatives to antibiotics and antimicrobial growth promoters in animal feed.
VETERINARY SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Palmy R. Jesudhasan, Sohini S. Bhatia, Kirthiram K. Sivakumar, Chandni Praveen, Kenneth J. Genovese, Haiqi L. He, Robert Droleskey, Jack L. McReynolds, James A. Byrd, Christina L. Swaggerty, Michael H. Kogut, David J. Nisbet, Suresh D. Pillai
Summary: Clostridium perfringens (Cp) is a bacterium causing necrotic enteritis in chickens, leading to significant economic losses in the poultry industry worldwide. Contaminated chicken meat can lead to foodborne illnesses in humans. Electron beam irradiation (eBeam) inactivates Cp effectively for use as a vaccine, reducing colonization in broiler chickens.
Article
Immunology
Jin Liu, Shuangqi Wu, Honghao Zhao, Chun Ye, Shulin Fu, Yu Liu, Ting Liu, Yinsheng Qiu
Summary: Baicalin-aluminum complex, synthesized from baicalin, inhibits the virulence-associated traits and virulence genes expression of Clostridium perfringens. It has potential as a candidate against C. perfringens infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Fangshen Guo, Fangyuan Wang, Haiyan Ma, Zhouzheng Ren, Xiaojun Yang, Xin Yang
Summary: The study reveals that dietary deoxynivalenol and Clostridium perfringens challenge have harmful effects on the jejunal health of broiler chickens, affecting mucosal expression and intestinal microbiota composition.
Article
Veterinary Sciences
Kriengwich Limpavithayakul, Nataya Charoenvisal, Somsak Pakpinyo
Summary: The PCR-RFLP molecular assay was verified as a convenient technique for detecting the MS-H vaccine strain, and the immune response mechanisms in vaccinated layer-type chickens were characterized. Vaccination stimulated immune response mechanisms in chickens with no significant difference between single and double doses.
Article
Veterinary Sciences
Doan Hoang Phu, Ruethai Narinthorn, Nguyen Thi Nhung, Niwat Chansiripornchai, Patrick J. Blackall, Conny Turni, Juan Carrique-Mas, Thotsapol Thomrongsuwannakij
Summary: Chicken in southern Thailand has different prevalence and resistance patterns of Campylobacter. Commercial broilers exhibit higher resistance to quinolones and lower resistance to macrolides and tetracycline compared to native chickens. Resistance patterns are more consistent within farms, and commercial broilers show higher homogeneity. Phenotypic and genotypic resistance have partial agreement among isolates.
Article
Veterinary Sciences
Sanjiv Kumar, Madhurendu Kumar Gupta, Sanjit Kumar, Tanmoy Rana
Summary: This study evaluated the relative efficacy of allopurinol and febuxostat, two important anti-gout agents, in controlling hyperuricemia/gout using a poultry model. The results showed that both allopurinol and febuxostat have definite potential for ameliorating hyperuricemia and gout in poultry, with febuxostat showing better effects compared to allopurinol.
Article
Veterinary Sciences
Robert Jan Molenaar, Remco Dijkman, Christiaan ter Veen, Annet Heuvelink, Fiona van Kaam, Marieke Augustijn, Anneke Feberwee
Summary: This report describes an outbreak of Salmonella Pullorum (SP) in a Dutch laying flock, causing increased mortality, decreased egg production, and neurological signs. SP was frequently isolated from various organs, and immunostaining showed cerebral granulomas in birds with neurological signs. Vaccination did not affect the detection of SP antibodies. Some clinically healthy birds had ovarian lesions associated with SP contact, but carrier status could not be confirmed. Phylogenetic analysis showed clonality of the SP isolates within the outbreak.
Article
Veterinary Sciences
Yingfei Sun, Yingjie Wang, Lulu Wang, Mengyun Zou, Xiuli Peng
Summary: This study investigates the regulation of miR-33-5p gene expression during MG infection. The researchers found an upregulation in pri-miR-33-5p and pre-miR-33-5p expression, indicating transcriptional regulation. They identified a binding motif for STAT5 in the miR-33-5p promoter element and showed that STAT5 modulates miR-33-5p transcription in response to MG infection. The overexpression of STAT5 led to increased miR-33-5p expression while suppressing JNK1 expression.