Article
Agronomy
Yong Jiang, Zhong Zhuang, Wenqian Jia, Ming Xie, Zhengkui Zhou, Jing Tang, Hao Bai, Guobin Chang, Guohong Chen, Shuisheng Hou
Summary: This study found differences in gene expression profiles related to lipid metabolism in the liver, sebum, and abdominal fat of fatty-type and lean-type ducks. The differentially expressed genes were enriched in various pathways, with key genes identified for lipid deposition in different tissues of ducks. These results provide insights into transcriptome regulation in lipid deposition and may aid in duck breeding.
Article
Veterinary Sciences
Min-Ju Jeong, Zerui Wang, Wen-Quan Zou, Yong-Chan Kim, Byung-Hoon Jeong
Summary: This study is the first to report the genetic characteristics of PRNP SNPs in Pekin ducks, finding five novel SNPs and observing linkage disequilibrium between some SNPs, as well as revealing the deleterious effects of a non-synonymous SNP on the aggregation propensity and solubility of Pekin duck PrP.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Virology
Kaliannan Durairaj, Thuy-Tien Thi Trinh, Su-Yeon Yun, Seon-Ju Yeo, Haan-Woo Sung, Hyun Park
Summary: The H6N6 subtype of avian influenza virus has been identified worldwide and poses a potential risk of animal-human transmission. A new H6N6 virus was isolated from Mallard ducks in South Korea, showing genetic linkage to Chinese and Vietnamese lineages. The isolated virus is identified as a low-pathogenic avian influenza virus with certain mutations that may enhance its pathogenicity. Continuous surveillance of H6N6 virus is crucial globally.
Article
Genetics & Heredity
Min-Ju Jeong, Yong-Chan Kim, Byung-Hoon Jeong
Summary: This study first reported the DNA sequence of the prion protein gene (PRNP) in Pekin ducks, showing that Pekin duck PrP is more similar to geese, has a high proportion of beta-sheets, and a higher aggregation propensity compared to avian PrPs. However, Pekin duck PrP with substitutions of chicken-specific amino acids displayed reduced aggregation propensity.
Article
Endocrinology & Metabolism
Xiaoya Chu, Aiman Javed, Muhammad Faizan Ashraf, Xiuge Gao, Shanxiang Jiang
Summary: This study established a method for isolating highly purified Leydig cells from duck testes and confirmed their biological function in synthesizing testosterone.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Veterinary Sciences
Sandra Vreman, Saskia A. Bergervoet, Rob Zwart, Norbert Stockhofe-Zurwieden, Nancy Beerens
Summary: Histopathology and virus distribution were compared in chickens and Pekin ducks infected with H5N6 avian influenza virus, revealing differences in viral antigen expression in different cell types and suggesting a lesser role of infected endothelial cells in systemic infection and disease progression in ducks.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Endocrinology & Metabolism
V. Tetel, S. Tonissen, G. S. Fraley
Summary: It is becoming more common for poultry scientists to use direct and indirect measures of stress hormones to monitor bird welfare. However, our understanding of the avian hypothalamic-pituitary-adrenal axis (HPA) is insufficient, leading to conflicting reports on stress responses. This study suggests that ducks may utilize more than just corticosterone to respond to stress and the time course of stressor response may depend on the sex of the bird.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2022)
Article
Microbiology
Abdelfattah H. Eladl, Nehal M. Nabil, Amal Awad, Shereen Badr, Amera F. Ebrahem, Maram M. Tawakol, Enas Hammad, Hanaa S. Ali, Reham A. El-Shafei
Summary: This study investigated the effect of nano-selenium supplementation on the growth performance, immune status, and cytokines production in Pekin ducklings vaccinated and challenged with Riemerella anatipestifer. The results showed that nano-selenium supplementation significantly improved the growth performance, immune status, and cytokines production. It also reduced mortality, bacterial shedding, and hepatic and renal damage.
VETERINARY MICROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Yang Zhang, Qiang Bao, Zhi Cao, Youqing Bian, Yu Zhang, Zhengfeng Cao, Guohong Chen, Qi Xu
Summary: This study evaluated the genetic resources of domestic and wild Mallard populations in China, revealing significant genetic diversity among domestic duck breeds. The findings provide valuable insights into the genetic makeup and possible origin of domestic ducks in China.
Article
Multidisciplinary Sciences
Yanfa Sun, Yeqiu Zhang, Qiong Wu, Rulong Lin, Hongping Chen, Min Zhang, Jiaqi Lin, Enrong Xu, Meng Li, Yicheng Cai, Fan Deng, Wen Yue, Haozhe Pan, Xiaobing Jiang, Yan Li
Summary: This study identified whole genome variants in high-egg producing and low-egg producing laying ducks. The genes with differential variants were associated with key functional pathways for poultry egg production. Further analysis revealed that the FZD6 gene polymorphisms were associated with early egg production and egg weight traits, suggesting FZD6 as a novel candidate gene for egg production traits in laying ducks.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Olivier Duriez, Yohan Sassi, Chloe Le Gall-Ladeveze, Lea Giraud, Robert Straughan, Lise Dauverne, Anna Terras, Thierry Boulinier, Remi Choquet, Anne van de Wiele, Julien Hirschinger, Jean-Luc Guerin, Guillaume Le Loc'h
Summary: A study found that terrestrial birds infected with highly pathogenic avian influenza (HPAI) virus exhibit immobility behavior during the breeding season, which may reduce the risk of virus transmission. However, these infections pose a threat to endangered vulture species, raising concerns about their resistance to the virus.
Article
Chemistry, Applied
Sanjun Jin, Qian Pang, Hao Yang, Xinping Diao, Anshan Shan, Xingjun Feng
Summary: The study found that dietary supplementation of resveratrol can enhance the antioxidant capacity, improve the color and texture of duck meat, and reduce lipid and protein oxidation reactions.
Article
Microbiology
Karolina Tarasiuk, Anna Kycko, Edyta Swieton, Lukasz Bocian, Krzysztof Wyrostek, Krzysztof Smietanka
Summary: In this study, the researchers examined the effects of high pathogenicity avian influenza virus (HPAIV) H5N8 infection on captive mallards. They found that naive mallards had a high mortality rate when infected with HPAIV H5N8, showing neurological signs and shedding large amounts of the virus. Mallards pre-exposed to low pathogenicity avian influenza virus (LPAIV) H5N1 had reduced symptoms and viral shedding, while those pre-exposed to LPAIV H3N8 remained healthy but still had detectable levels of the virus. HPAIV H5N8 was capable of transmission to contact birds, causing mild-to-moderate tissue damage.
Article
Parasitology
Junjie Hu, Mingzhu Zhang, Zhipeng Wu, Hongxia Zeng, Jianping Tao
Summary: A new species, Sarcocystis platyrhynchosi, was discovered in domestic ducks in China. This is the first record of Sarcocystis spp. from waterfowl in China. Further studies using additional molecular markers are needed to clarify the relationships among these species.
PARASITES & VECTORS
(2023)
Article
Veterinary Sciences
Erica Spackman, Mary J. Pantin-Jackwood, Scott A. Lee, Diann Prosser
Summary: Highly pathogenic avian influenza viruses of the clade 2.3.4.4 goose/Guangdong/1996 H5 lineage continue to cause outbreaks in poultry and wild birds worldwide. A recent incursion of H5N1 clade 2.3.4.4b virus into North America has resulted in widespread outbreaks in poultry and consistent detections across diverse bird families and occasionally mammals. Mallards, as primary reservoirs of AIV, were found to have subclinical infections, shed virus through oral and cloacal routes, and could serve as efficient reservoirs to amplify and disseminate the virus.
Article
Biochemistry & Molecular Biology
Insun Park, Linda K. Johnson, Allaura Cox, Brian R. Branchford, Jorge Di Paola, Erez M. Bublil, Tomas Majtan
Article
Veterinary Sciences
Cara M. Mitchell, Linda K. Johnson, Marcus J. Crim, Charles E. Wiedmeyer, Umarani Pugazhenthi, Susan Tousey, Daniel J. Tollin, Lauren M. Habenicht, Michael K. Fink, Derek L. Fong, Jori K. Leszczynski, Christopher A. Manuel
COMPARATIVE MEDICINE
(2020)
Article
Infectious Diseases
Michelle Nelson, Alejandro Nunez, Sarah A. Ngugi, Timothy P. Atkins
Summary: This paper discusses the ingestion model of melioidosis and found that challenge doses greater than 6.2 x 10^6 cfu result in acute, lethal, febrile disease. The study also revealed that the bacteria primarily spread through lymphatic draining.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Infectious Diseases
Fabian Z. X. Lean, Alejandro Nunez, Simon Spiro, Simon L. Priestnall, Sandra Vreman, Dalan Bailey, Joe James, Ethan Wrigglesworth, Alejandro Suarez-Bonnet, Carina Conceicao, Nazia Thakur, Alexander M. P. Byrne, Stuart Ackroyd, Richard J. Delahay, Wim H. M. van der Poel, Ian H. Brown, Anthony R. Fooks, Sharon M. Brookes
Summary: ACE2 serves as the receptor for coronaviruses and shows varied distribution in different animal tissues, affecting host susceptibility. The presence of ACE2 in the respiratory tract varies among species, providing insights into the receptor-mediated viral infection.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Microbiology
Pedro J. Sanchez-Cordon, Tobias Floyd, Daniel Hicks, Helen R. Crooke, Stephen McCleary, Ronan R. McCarthy, Rebecca Strong, Linda K. Dixon, Aleksija Neimanis, Emil Wikstrom-Lassa, Dolores Gavier-Widen, Alejandro Nunez
Summary: The understanding of clinicopathological forms caused by different genotypes of the African swine fever virus is limited. A study on the Ken05/Tk1 isolate (genotype X) showed that high doses can induce acute forms of ASF, while medium doses mainly lead to acute forms and occasionally subacute forms.
Article
Virology
Arran J. Folly, Denise A. Marston, Megan Golding, Shweta Shukla, Rebekah Wilkie, Fabian Z. X. Lean, Alejandro Nunez, Lisa Worledge, James Aegerter, Ashley C. Banyard, Anthony R. Fooks, Nicholas Johnson, Lorraine M. McElhinney
Summary: The UK has detected cases of EBLV-1 in serotine bats through passive surveillance, indicating a recent emergence of this rabies virus possibly associated with the natural movement of bats from the near continent.
Article
Veterinary Sciences
Christopher A. Manuel, Linda K. Johnson, Uma Pugazhenthi, Derek L. Fong, Michaelk Fink, Lauren M. Habenicht, Jori K. Leszczynski, Diana Ir, Charles E. Robertson, Michael J. Schurr, Daniel N. Frank
Summary: This study evaluated the effectiveness of oral prophylactic antibiotics in preventing C. bovis infection and analyzed their impact on the skin microbiome of mice. The results showed that 14 days of prophylactic antibiotics can prevent the persistence of C. bovis infection. However, the effects of antibiotics on commensal bacteria and potential impacts on xenograft models need to be further considered.
COMPARATIVE MEDICINE
(2022)
Article
Immunology
Sarah Keep, Brigid Veronica Carr, Fabian Z. X. Lean, Albert Fones, Joseph Newman, Giulia Dowgier, Graham Freimanis, Eleni Vatzia, Noemi Polo, Holly Everest, Isobel Webb, Adam Mcnee, Basu Paudyal, Nazia Thakur, Alejandro Nunez, Ronan MacLoughlin, Helena Maier, John Hammond, Dalan Bailey, Ryan Waters, Bryan Charleston, Toby Tuthill, Paul Britton, Erica Bickerton, Elma Tchilian
Summary: In response to the SARS-CoV-2 pandemic, a porcine respiratory coronavirus (PRCV) model has been developed for in-depth evaluation of the pathogenesis, virology, and immune responses of this virus family. Pigs, which share similar physiology and immunology with humans, were used as a natural host for PRCV. The study found that different PRCV strains induced varying degrees of lung pathology, with those causing more severe lung damage being able to replicate in ex vivo tracheal organ cultures, as well as in the trachea and lung in vivo.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Fabian Z. X. Lean, Ana Gomez Vitores, Scott M. Reid, Ashley C. Banyard, Ian H. Brown, Alejandro Nunez, Rowena D. E. Hansen
Summary: Highly pathogenic avian influenza virus has re-emerged in the UK and continues to have a global impact. This study investigates the pathological features of the virus in poultry and wild birds, identifying pancreatic and splenic necrosis as common findings.
Article
Parasitology
Luis M. Hernandez-Triana, Arran J. Folly, Sanam Sewgobind, Fabian Z. X. Lean, Stuart Ackroyd, Alejandro Nunez, Sarah Delacour, Andrea Drago, Patrizia Visentin, Karen L. Mansfield, Nicholas Johnson
Summary: Investigations have shown that Asian tiger mosquitoes from different locations in Europe exhibit varying susceptibility to JEV, while Culex quinquefasciatus is highly susceptible to the virus. Both species have the potential to act as vectors for JEV, facilitating its emergence into new regions.
PARASITES & VECTORS
(2022)
Article
Veterinary Sciences
Craig S. Ross, David Sutton, Paul Skinner, Sahar Mahmood, Felicity Wynne, Brandon Londt, Chad M. Fuller, Jo Mayers, Alejandro Nunez, Daniel J. Hicks, Sharon M. Brookes, Ashley C. Banyard, Ian H. Brown
Summary: Newcastle disease (ND) is a significant disease of poultry caused by virulent forms of avian paramyxovirus-1 (APMV-1). Pigeon paramyxovirus 1 (PPMV-1) can also cause infections. A study investigated the pathogenesis and transmission of a specific APMV-1 strain in game birds and compared it to a contemporary PPMV-1 strain. The study suggested that game birds may play a role in the transmission and epidemiology of APMV-1 viruses.
Article
Infectious Diseases
Thomas R. Laws, Kay B. Barnes, Dominic C. Jenner, Alejandro Nunez, Mark Richards, Joanne E. Thwaite, Andreas Vente, David Rushton, Michelle Nelson, Sarah Harding
Summary: This study investigated the efficacy of two drugs in treating melioidosis in mice. It was found that compared to co-trimoxazole, finafloxacin was more effective in preventing re-infection and controlling clinical symptoms, weight loss, and bacterial load.
Article
Biotechnology & Applied Microbiology
Fabian Z. X. Lean, Anne-Laure Leblond, Alexander M. P. Byrne, Benjamin Mollett, Joe James, Samantha Watson, Shellene Hurley, Sharon M. Brookes, Achim Weber, Alejandro Nunez
Summary: This study reports the detection of subclinical infection of ferret hepatitis E virus (FRHEV) in a group of laboratory ferrets. The presence of FRHEV was confirmed through histopathology, viral metagenomic analysis, and in situ hybridization. Routine monitoring of ferret populations is recommended to avoid incorrect attribution of liver disease detected in experiments.
JOURNAL OF GENERAL VIROLOGY
(2022)
Article
Virology
Craig S. Ross, Paul Skinner, David Sutton, Jo Mayers, Alex Nunez, Sharon M. Brookes, Ashley C. Banyard, Ian H. Brown
Summary: Newcastle Disease (ND), caused by virulent forms of Avian orthoavulavirus serotype-1 (AOAV-1), is a globally significant avian disease. The study investigated the risk of AOAV-1-infected game birds to the UK poultry industry. It demonstrated that both chickens and pheasants are susceptible to infection, leading to high mortality and onward transmission, while partridges serve as intermediate hosts with reduced mortality and transmission.
Article
Virology
Michelle Nelson, Lyn M. O'Brien, Carwyn Davies, Emma Keyser, Wendy Butcher, Sophie J. Smither, Alejandro Nunez, F. Javier Salguero, M. Stephen Lever
Summary: In this experiment, common marmosets were challenged with two strains of Middle East respiratory syndrome coronavirus (MERS-CoV) through different routes of infection. The results showed that aerosol exposure resulted in the most severe disease response, while intranasal and oral routes caused mild or no disease. These findings indicate the importance of an early immunological response in controlling the disease.
JOURNAL OF VIROLOGY
(2022)
Article
Veterinary Sciences
Kriengwich Limpavithayakul, Nataya Charoenvisal, Somsak Pakpinyo
Summary: The PCR-RFLP molecular assay was verified as a convenient technique for detecting the MS-H vaccine strain, and the immune response mechanisms in vaccinated layer-type chickens were characterized. Vaccination stimulated immune response mechanisms in chickens with no significant difference between single and double doses.
Article
Veterinary Sciences
Doan Hoang Phu, Ruethai Narinthorn, Nguyen Thi Nhung, Niwat Chansiripornchai, Patrick J. Blackall, Conny Turni, Juan Carrique-Mas, Thotsapol Thomrongsuwannakij
Summary: Chicken in southern Thailand has different prevalence and resistance patterns of Campylobacter. Commercial broilers exhibit higher resistance to quinolones and lower resistance to macrolides and tetracycline compared to native chickens. Resistance patterns are more consistent within farms, and commercial broilers show higher homogeneity. Phenotypic and genotypic resistance have partial agreement among isolates.
Article
Veterinary Sciences
Sanjiv Kumar, Madhurendu Kumar Gupta, Sanjit Kumar, Tanmoy Rana
Summary: This study evaluated the relative efficacy of allopurinol and febuxostat, two important anti-gout agents, in controlling hyperuricemia/gout using a poultry model. The results showed that both allopurinol and febuxostat have definite potential for ameliorating hyperuricemia and gout in poultry, with febuxostat showing better effects compared to allopurinol.
Article
Veterinary Sciences
Robert Jan Molenaar, Remco Dijkman, Christiaan ter Veen, Annet Heuvelink, Fiona van Kaam, Marieke Augustijn, Anneke Feberwee
Summary: This report describes an outbreak of Salmonella Pullorum (SP) in a Dutch laying flock, causing increased mortality, decreased egg production, and neurological signs. SP was frequently isolated from various organs, and immunostaining showed cerebral granulomas in birds with neurological signs. Vaccination did not affect the detection of SP antibodies. Some clinically healthy birds had ovarian lesions associated with SP contact, but carrier status could not be confirmed. Phylogenetic analysis showed clonality of the SP isolates within the outbreak.
Article
Veterinary Sciences
Yingfei Sun, Yingjie Wang, Lulu Wang, Mengyun Zou, Xiuli Peng
Summary: This study investigates the regulation of miR-33-5p gene expression during MG infection. The researchers found an upregulation in pri-miR-33-5p and pre-miR-33-5p expression, indicating transcriptional regulation. They identified a binding motif for STAT5 in the miR-33-5p promoter element and showed that STAT5 modulates miR-33-5p transcription in response to MG infection. The overexpression of STAT5 led to increased miR-33-5p expression while suppressing JNK1 expression.