Article
Agriculture, Dairy & Animal Science
Aaron Forga, Kabel Robbins, Andrew Smith, Makenly Coles, Guillermo Tellez-Isaias, Christine N. Vuong, Billy Hargis, Danielle Graham
Summary: Clostridial cellulitis or dermatitis affects commercial turkey flocks and has been controlled with antibiotics, but alternatives are needed. Bacterin-toxoid vaccination programs have been effective in preventing clostridial diseases. Further research is proposed to understand the relationship between culture phase and antigenic components produced by CS.
Article
Veterinary Sciences
Valeria Criollo, Carissa Gaghan, Feba John, Eric Orozco, Anil Thachil, Rocio Crespo, Raveendra R. Kulkarni
Summary: Clostridial dermatitis (CD) is an economically important emerging disease of turkeys caused by Clostridium septicum. The study found that CD-affected turkeys had significantly higher levels of immune gene expression and antibody production. This suggests that turkeys respond to C. septicum infection by activating the immune system and inducing an inflammatory response.
Review
Pediatrics
Renato Gualtieri, Gabriel Bronz, Mario G. Bianchetti, Sebastiano A. G. Lava, Elena Giuliano, Gregorio P. Milani, Luca M. M. Jermini
Summary: Perianitis is mainly seen in boys under 7 years old, presenting with symptoms such as defecation disorders, perianal pain, local itch, and rectal bleeding. It is hypothesized to be caused by digital inoculation from the nasopharynx to the anus. There is a need for increased awareness of this condition among healthcare professionals.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Veterinary Sciences
Jenny Stracke, Robby Andersson, Nina Volkmann, Birgit Spindler, Jan Schulte-Landwehr, Ronald Guenther, Nicole Kemper
Summary: Footpad dermatitis is an important indicator of animal welfare in turkeys, and automated systems for assessing it can be useful. However, the initial results showed deficiencies in the automated system, particularly in detecting the metatarsal footpad and footpad alterations. While modifications improved observer reliability, detection accuracy remained a challenge.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Jenny Stracke, Nina Volkmann, Franziska May, Stefanie Dohring, Nicole Kemper, Birgit Spindler
Summary: This study provides a detailed analysis of alterations on the digits of turkeys for the first time. The results show that including the evaluation of alterations on digits could refine the present FPD scoring system, especially when using FPD as an animal welfare indicator.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Yiru Dong, Gregory S. Fraley, Janice M. Siegford, Fengqing Zhu, Marisa A. Erasmus
Summary: This study investigated age-related changes in turkey welfare measures and walking ability as influenced by different types of environmental enrichment. The results showed that wing feather quality improved with age in the straw bale and tunnel groups. Footpad condition worsened over time for turkeys in all treatment groups except for the straw bale group. Gait worsened with increasing age in all treatment groups.
Review
Immunology
Francisco A. Uzal, Mauricio A. Navarro, Javier Asin, Eileen E. Henderson
Summary: Clostridial diseases of horses can be categorized into enteric/enterotoxic, histotoxic, and neurotoxic types. Enteric/enterotoxic diseases are characterized by enterocolitis caused by Clostridium perfringens type C and Clostridioides difficile. Histotoxic diseases include gas gangrene, Tyzzer disease, and infectious necrotic hepatitis. Neurotoxic diseases are tetanus and botulism caused by Clostridium tetani and Clostridium botulinum. Diagnosis can be challenging due to the presence of some agents in tissues of normal animals.
Review
Microbiology
Francisco A. Uzal, Mauricio A. Navarro, Javier Asin, Oriol Boix, Isaac Ballara-Rodriguez, Xavier Gibert
Summary: Clostridium perfringens type C and Clostridioides difficile are the main pathogens causing neonatal diarrhea in swine. Diagnosis is based on history, clinical signs, gross lesions, and histological findings, with confirmation through detecting specific toxins in intestinal contents or feces. Isolation of these pathogens is suggestive but not enough to confirm diagnosis. Diagnosis of Clostridium perfringens type A-associated diarrhea is more challenging due to undefined diagnostic criteria and unclear roles of specific toxins. This paper aims to provide a comprehensive overview of the etiology, epidemiology, pathogenesis, clinical signs, pathology, and diagnosis of these clostridial enteric diseases in piglets.
VETERINARY MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Jan Berend Lingens, Christian Visscher, Christian Suerie, Richard Grone, Andreas von Felde, Volker Wilke, Amr Abd El-Wahab
Summary: This study aimed to test the effects of rye inclusion up to 10% on growth, excreta, and/or litter dry matter, and foot pad health in turkeys. Results showed no significant differences in final body weight between the control and experimental groups. The inclusion of rye also did not significantly affect litter dry matter content and food pad dermatitis scoring.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Infectious Diseases
Ying Liu, Jianfei Zhu, Shaoqi Qu, Jianzhong Shen, Kui Zhu
Summary: In this study, plant-derived antibacterial xanthones, especially alpha-mangostin (AMG) from mangosteen peel, showed remarkable activities against Clostridium perfringens. Structure-activity relationship analysis revealed that prenylation influenced the activity of xanthones. The efficacy of AMG was also demonstrated in a broiler chicken necrotic enteritis model infected with Clostridium perfringens, where AMG maintained gut microbiome homeostasis and promoted intestinal barrier integrity.
Article
Biochemistry & Molecular Biology
Aleksandra Klisic, Mirjana Bakic, Vesna Karanikolic
Summary: This study compared serum biomarkers of oxidative stress in patients with psoriasis and atopic dermatitis, finding that catalase exhibited good diagnostic accuracy in distinguishing between the two diseases. The results suggest the potential use of antioxidants as a therapeutic strategy for these skin inflammatory diseases.
Article
Biochemistry & Molecular Biology
Oriana Simonetti, Tiziana Bacchetti, Gianna Ferretti, Elisa Molinelli, Giulio Rizzetto, Luisa Bellachioma, Annamaria Offidani
Summary: The study revealed that children with atopic dermatitis (AD) have higher levels of lipid peroxidation and lower antioxidant defense, with abnormal activity of PON enzymes, indicating a relationship between oxidative stress and inflammation in AD patients.
Article
Biochemistry & Molecular Biology
Minkyoung Sung, Soo-Eun Sung, Kyung-Ku Kang, Joo-Hee Choi, Sijoon Lee, KilSoo Kim, Ju-Hyeon Lim, Gun Woo Lee, Hyo-Deog Rim, Seunghee Won, Byung-Soo Kim, Kyungmin Kim, Seoyoung Jang, Sang Gyu Kwak, Jungmin Woo, Min-Soo Seo
Summary: Atopic dermatitis (AD) is a chronic allergic inflammatory skin disease characterized by symptoms like eczema and itching. Psychological stress can trigger neuroinflammation in the brain in AD patients, leading to changes in microRNAs (miRNAs) in neuronal exosomes (nEVs). This study found that certain miRNAs in nEVs may serve as stress-related biomarkers associated with AD and stress-induced depression.
Article
Agriculture, Dairy & Animal Science
R. Lindenwald, H. -J. Schuberth, B. Spindler, S. Rautenschlein
Summary: Turkeys housed in poorly structured commercial environments often experience stress and behavioral issues. This study found that environmental enrichment can improve behavioral repertoire and health parameters in turkeys, suggesting a potential modulatory effect on immunity and overall fitness. Further research is needed to understand the relationship between behavior and health parameters in more detail.
Review
Microbiology
Kathleen E. Orrell, Roman A. Melnyk
Summary: Large clostridial toxins (LCTs) are a family of bacterial exotoxins that infiltrate and destroy target cells, implicated as the primary virulence factors in various infections. Understanding the mechanism of LCT intoxication through recent structural work and toxin subtyping analysis is crucial for elucidating their role in infection and disease. Research on genomic discovery and characterization of LCT homologues provides valuable insights into this enigmatic family of toxins, offering perspectives on emerging questions and future research directions.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2021)