期刊
AUTOPHAGY
卷 9, 期 7, 页码 1097-1099出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.24634
关键词
podocyte; Vps34; phosphoinositide 3-kinase; Pik3c3; endocytosis; autophagy; autophago-lysosomal formation; glomerulosclerosis; proteinuria
类别
资金
- Marie Curie Career Integration Grant
- Margarete von Wrangell Habilitations-Stipendium
- Deutsche Forschungsgesellschaft DFG [KFO 201, SFB 992]
- Joint transnational Grant-BMBF
- Excellence Initiative of the German Federal Government [EXC 294]
- BMBF GerontoSys2-Project NephAge
- Spemann Graduate School [GSC-4]
- Excellence Initiative of the German State Government [EXC 294]
Phosphatidylinositol phosphates are key regulators of vesicle identity, formation and trafficking. In mammalian cells, the evolutionarily conserved class III PtdIns 3-kinase PIK3C3/VPS34 is part of a large multiprotein complex that catalyzes the localized phosphorylation of phosphatidylinositol to phosphatidylinositol-3-phosphate (PtdIns3P). We demonstrate that PIK3C3 has a key function in vesicular trafficking, endocytosis and autophagosome-autolysosome formation in the highly specialized glomerular podocytes.
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