期刊
AUTOPHAGY
卷 9, 期 4, 页码 622-623出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.23559
关键词
endoplasmic reticulum; autophagy; Arabidopsis; IRE1; ER stress
类别
资金
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1051818] Funding Source: National Science Foundation
Eukaryotic cells have developed sophisticated strategies to contend with environmental stresses faced in their lifetime. Endoplasmic reticulum (ER) stress occurs when the accumulation of unfolded proteins within the ER exceeds the folding capacity of ER chaperones. ER stress responses have been well characterized in animals and yeast, and autophagy has been suggested to play an important role in recovery from ER stress. In plants, the unfolded protein response signaling pathways have been studied, but changes in ER morphology and ER homeostasis during ER stress have not been analyzed previously. Autophagy has been reported to function in tolerance of several stress conditions in plants, including nutrient deprivation, salt and drought stresses, oxidative stress, and pathogen infection. However, whether autophagy also functions during ER stress has not been investigated. The goal of our study was to elucidate the role and regulation of autophagy during ER stress in Arabidopsis thaliana.
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