期刊
AUTOPHAGY
卷 8, 期 6, 页码 979-981出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.20232
关键词
autophagy; glioblastoma; angiogenesis; hypoxia
类别
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NINDS NIH HHS [5K02NS64167-2, K02 NS064167] Funding Source: Medline
While anti-angiogenic therapy was initially greeted enthusiastically by the cancer community, initial successes with this therapeutic modality were tempered by the failure of angiogenesis inhibitors to produce sustained clinical responses in most patients, with resistance to the inhibitors frequently developing. We recently reported that hypoxia increases after the devascularization caused by anti-angiogenic therapy, consistent with the goals of these therapies, but that some tumor cells become resistant and survive the hypoxic insult elicited by anti-angiogenic therapy through autophagy by activating both AMPK and HIF1A pathways. These findings suggest that modulating the autophagy pathway may someday allow anti-angiogenic therapy to fulfill its therapeutic potential. However, further work will clearly be needed to develop more potent and specific autophagy inhibitors and to better understand the regulators of autophagy in malignant cells.
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